Structure information

ghrelin receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6KO5

SPECIES

Homo sapiens

RESOLUTION

3.300

PREFERRED CHAIN

A

REFERENCE

PUBLICATION DATE

Aug. 12, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
6-(4-Bromo-2-fluorophenoxy)-2-methyl-3-[[(3S)-1-propan-2-ylpiperidin-3-yl]methyl]pyrido[3,2-d]pyrimidin-4-one D99 2.60x60 TM2 polar (charge-charge)
6-(4-Bromo-2-fluorophenoxy)-2-methyl-3-[[(3S)-1-propan-2-ylpiperidin-3-yl]methyl]pyrido[3,2-d]pyrimidin-4-one R102 2.63x63 TM2 polar (charge-assisted hydrogen bond)
6-(4-Bromo-2-fluorophenoxy)-2-methyl-3-[[(3S)-1-propan-2-ylpiperidin-3-yl]methyl]pyrido[3,2-d]pyrimidin-4-one E124 3.33x33 TM3 polar (charge-assisted hydrogen bond)
6-(4-Bromo-2-fluorophenoxy)-2-methyl-3-[[(3S)-1-propan-2-ylpiperidin-3-yl]methyl]pyrido[3,2-d]pyrimidin-4-one L181 4.63x64 TM4 hydrophobic
6-(4-Bromo-2-fluorophenoxy)-2-methyl-3-[[(3S)-1-propan-2-ylpiperidin-3-yl]methyl]pyrido[3,2-d]pyrimidin-4-one V182 4.64x65 TM4 hydrophobic
6-(4-Bromo-2-fluorophenoxy)-2-methyl-3-[[(3S)-1-propan-2-ylpiperidin-3-yl]methyl]pyrido[3,2-d]pyrimidin-4-one F279 6.51x51 TM6 hydrophobic
6-(4-Bromo-2-fluorophenoxy)-2-methyl-3-[[(3S)-1-propan-2-ylpiperidin-3-yl]methyl]pyrido[3,2-d]pyrimidin-4-one R283 6.55x55 TM6 polar (charge-assisted hydrogen bond)
6-(4-Bromo-2-fluorophenoxy)-2-methyl-3-[[(3S)-1-propan-2-ylpiperidin-3-yl]methyl]pyrido[3,2-d]pyrimidin-4-one R283 6.55x55 TM6 polar (charge-assisted hydrogen bond)
6-(4-Bromo-2-fluorophenoxy)-2-methyl-3-[[(3S)-1-propan-2-ylpiperidin-3-yl]methyl]pyrido[3,2-d]pyrimidin-4-one F309 7.39x38 TM7 hydrophobic
6-(4-Bromo-2-fluorophenoxy)-2-methyl-3-[[(3S)-1-propan-2-ylpiperidin-3-yl]methyl]pyrido[3,2-d]pyrimidin-4-one F312 7.42x41 TM7 hydrophobic

Ligands

6-(4-Bromo-2-fluorophenoxy)-2-methyl-3-[[(3S)-1-propan-2-ylpiperidin-3-yl]methyl]pyrido[3,2-d]pyrimidin-4-one

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Residue Diagrams

L N G A I G V V F L A V C T A T V G A L 1 S S M A F S D L L I F L C M P L D L V R 2 A T I T L V T A Y T C S E S V F Q F L K 3 V K L V I F V I W A V A F C S A G P I 4 Y L V T L C F V P L F F F I S S V W V M 5 A V V V F A F I L C W L P F H V G R Y L 6 I P N I A A S L Y F L V F S V L N C Y 7
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ICL1 R E L R ICL1ECL1 R P W N F ECL1ICL2 P L R A K V V V ICL2ECL2 G V E H E N G T D P W D T N E C R P T E F A V R S ECL2ICL3 A V V G A ICL3ECL3 F E P G S L E I ECL3N-term M W N A T P S E E P G F N L T L A D L D W D A S P G N D S L G D E L L Q L F N-termC-term F S Q R K L S T L K D E S S R A W T E S S I N T C-term P A P L L A G V T A T C V A L F V V G I A G N L L T M L V V S R F T T T N L Y L S S M A F S D L L I F L C M P L D L V R L W Q Y G D L L C K L F Q F V S E S C T Y A T V L T I T A L S V E R Y F A I C F T K G R V K L V I F V I W A V A F C S A G P I F V L V G L L T V M V W V S S I F F F L P V F C L T V L Y S L I G R K L W R R R R G D S L R D Q N H K Q T V K M L A V V V F A F I L C W L P F H V G R Y L F S K S A Q I S Q Y C N L V S F V L F Y L S A A I N P I L Y N I M S K K V F R E P Y R V A L L G F
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Residue Table


GPCRdb(A)
GPCRdb(A)
ghrelin receptor
TM2
2x60 2.60x60 D99
2x63 2.63x63 R102
TM3
3x33 3.33x33 E124
TM4
4x64 4.63x64 L181
4x65 4.64x65 V182
TM6
6x51 6.51x51 F279
6x55 6.55x55 R283
TM7
7x38 7.39x38 F309
7x41 7.42x41 F312