Structure information

ghrelin receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6KO5

SPECIES

Homo sapiens

RESOLUTION

3.300

PREFERRED CHAIN

A

REFERENCE

10.1038/S41467-020-17554-1

PUBLICATION DATE

Aug. 12, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL1956994 D99 2.60x60 TM2 polar (charge-assisted hydrogen bond)
CHEMBL1956994 R102 2.63x63 TM2 polar (charge-assisted hydrogen bond)
CHEMBL1956994 Q120 3.29x29 TM3 Van der Waals
CHEMBL1956994 S123 3.32x32 TM3 Van der Waals
CHEMBL1956994 E124 3.33x33 TM3 polar (charge-assisted hydrogen bond)
CHEMBL1956994 I178 4.60x61 TM4 Van der Waals
CHEMBL1956994 L181 4.63x64 TM4 hydrophobic
CHEMBL1956994 L181 4.63x64 TM4 Van der Waals
CHEMBL1956994 V182 4.64x65 TM4 hydrophobic
CHEMBL1956994 P200 45.52x52 ECL2 Van der Waals
CHEMBL1956994 L210 5.36x36 TM5 Van der Waals
CHEMBL1956994 F279 6.51x51 TM6 Van der Waals
CHEMBL1956994 F279 6.51x51 TM6 hydrophobic
CHEMBL1956994 R283 6.55x55 TM6 polar (charge-assisted hydrogen bond)
CHEMBL1956994 F309 7.39x38 TM7 Van der Waals
CHEMBL1956994 F309 7.39x38 TM7 hydrophobic
CHEMBL1956994 F312 7.42x41 TM7 hydrophobic
CHEMBL1956994 F312 7.42x41 TM7 Van der Waals
CHEMBL1956994 Y313 7.43x42 TM7 Van der Waals
CHEMBL1956994 Y313 7.43x42 TM7 hydrophobic

Ligands

CHEMBL1956994

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Residue Diagrams

L N G A I G V V F L A V C T A T V G A L 1 S S M A F S D L L I F L C M P L D L V R 2 A T I T L V T A Y T C S E S V F Q F L K 3 V K L V I F V I W A V A F C S A G P I 4 Y L V T L C F V P L F F F I S S V W V M 5 A V V V F A F I L C W L P F H V G R Y L 6 I P N I A A S L Y F L V F S V L N C Y 7
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ICL1 R E L R ICL1ECL1 R P W N F ECL1ICL2 P L R A K V V V ICL2ECL2 G V E H E N G T D P W D T N E C R P T E F A V R S ECL2ICL3 A V V G A ICL3ECL3 P G S ECL3N-term M W N A T P S E E P G F N L T L A D L D W D A S P G N D S L G D E L L Q L F N-termC-term F S Q R K L S T L K D E S S R A W T E S S I N T C-term P A P L L A G V T A T C V A L F V V G I A G N L L T M L V V S R F T T T N L Y L S S M A F S D L L I F L C M P L D L V R L W Q Y G D L L C K L F Q F V S E S C T Y A T V L T I T A L S V E R Y F A I C F T K G R V K L V I F V I W A V A F C S A G P I F V L V G L L T V M V W V S S I F F F L P V F C L T V L Y S L I G R K L W R R R R G D S L R D Q N H K Q T V K M L A V V V F A F I L C W L P F H V G R Y L F S K S F E L E I A Q I S Q Y C N L V S F V L F Y L S A A I N P I L Y N I M S K K V F R E P Y R V A L L G F
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Residue Table


GPCRdb(A)
GPCRdb(A)
ghrelin receptor
TM2
2x60 2.60x60 D99
2x63 2.63x63 R102
TM3
3x29 3.29x29 Q120
3x32 3.32x32 S123
3x33 3.33x33 E124
TM4
4x61 4.60x61 I178
4x64 4.63x64 L181
4x65 4.64x65 V182
ECL2
45x52 45.52x52 P200
TM5
5x36 5.36x36 L210
TM6
6x51 6.51x51 F279
6x55 6.55x55 R283
TM7
7x38 7.39x38 F309
7x41 7.42x41 F312
7x42 7.43x42 Y313