PDB
6KPF
Resolution
2.9 Å
Released
Feb. 12, 2020
Receptor
CB2
Class
A
Species
Homo sapiens
Ligand
Function
AM12033
Agonist
Reference
10.1016/J.CELL.2020.01.008

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Ligand Amino Acid Generic Number Segment Interaction Type
AM12033 Y25 N-term Van der Waals
AM12033 F87 2.57x57 TM2 aromatic (edge-to-face)
AM12033 F87 2.57x57 TM2 hydrophobic
AM12033 S90 2.60x60 TM2 Van der Waals
AM12033 F91 2.61x61 TM2 hydrophobic
AM12033 F94 2.64x64 TM2 hydrophobic
AM12033 H95 2.65x65 TM2 Van der Waals
AM12033 F106 3.25x25 TM3 Van der Waals
AM12033 I110 3.29x29 TM3 hydrophobic
AM12033 V113 3.32x32 TM3 hydrophobic
AM12033 T114 3.33x33 TM3 hydrophobic
AM12033 F117 3.36x36 TM3 hydrophobic
AM12033 F183 ECL2 aromatic (edge-to-face)
AM12033 F183 ECL2 hydrophobic
AM12033 P184 ECL2 hydrophobic
AM12033 I186 ECL2 Van der Waals
AM12033 Y190 5.39x39 TM5 Van der Waals
AM12033 L191 5.40x40 TM5 Van der Waals
AM12033 W194 5.43x43 TM5 hydrophobic
AM12033 W258 6.48x48 TM6 hydrophobic
AM12033 V261 6.51x51 TM6 hydrophobic
AM12033 F281 7.35x34 TM7 Van der Waals
AM12033 S285 7.39x38 TM7 Van der Waals
AM12033 C288 7.42x41 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 H Q L R R ICL1ECL1 F H G V D ECL1ICL2 P P S Y K A L L ICL2ECL2 W T C C P R P C S E L F P L I ECL2ICL3 H Q D R Q V P G M A R M ICL3ECL3 T L ECL3N-term M E E C W V T E I A N G S K D G L D S N P M K D Y M I L N-termC-term C V R G L G S E A K E E A P R S S V T E T E A D G K I T P W P D S R D L D L S D C C-term S G P Q K T A V A V L C T L L G L L S A L E N V A V L Y L I L S S K P S Y L F I G S L A G A D F L A S V V F A C S F V N F H V S K A V F L L K I G S V T M T F T A S V G S L L L T A I D R Y L C L R Y T R G R A L V T L G I M W V L S A L V S Y L P L M G P N D Y L L S W L L F I A F L F S G I I Y T Y G H V L W K A H Q H V A S L S G R L D V R L A K T L G L V L A V L L I C W F P V L A L M A H S L A T S D Q V K K A F A F C S M L C L I N S M V N P V I Y A L R S G E A H H W K K I R S S C L A H
Helix box plot — Download: PNG | SVG V N E L A S L L G L L T C L V A V A T K 1 G S L A G A D F L A S V V F A C S F V N 2 L L L S G V S A T F T M T V S G I K L L 3 A L V T L G I M W V L S A L V S Y L P L 4 Y T Y I I G S F L F A I F L L W S L L Y 5 G L V L A V L L I C W F P V L A L M A H 6 V P N V M S N I L C L M S C F A F A K 7

GPCRdb(A)
GPCRdb(A)
CB2 receptor
TM2
2x57 2.57x57 F87
2x60 2.60x60 S90
2x61 2.61x61 F91
2x64 2.64x64 F94
2x65 2.65x65 H95
TM3
3x25 3.25x25 F106
3x29 3.29x29 I110
3x32 3.32x32 V113
3x33 3.33x33 T114
3x36 3.36x36 F117
TM5
5x39 5.39x39 Y190
5x40 5.40x40 L191
5x43 5.43x43 W194
TM6
6x48 6.48x48 W258
6x51 6.51x51 V261
TM7
7x34 7.35x34 F281
7x38 7.39x38 S285
7x41 7.42x41 C288