Structure information

α2C-adrenoceptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6KUW

SPECIES

Homo sapiens

RESOLUTION

2.800

PREFERRED CHAIN

A

REFERENCE

PUBLICATION DATE

Dec. 4, 2019

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
(8Ar,12aS,13aR)-12-ethylsulfonyl-3-methoxy-5,6,8,8a,9,10,11,12a,13,13a-decahydroisoquinolino[2,1-g][1,6]naphthyridine D131 3.32x32 TM3 polar (charge-charge)
(8Ar,12aS,13aR)-12-ethylsulfonyl-3-methoxy-5,6,8,8a,9,10,11,12a,13,13a-decahydroisoquinolino[2,1-g][1,6]naphthyridine V132 3.33x33 TM3 hydrophobic
(8Ar,12aS,13aR)-12-ethylsulfonyl-3-methoxy-5,6,8,8a,9,10,11,12a,13,13a-decahydroisoquinolino[2,1-g][1,6]naphthyridine C135 3.36x36 TM3 hydrophobic
(8Ar,12aS,13aR)-12-ethylsulfonyl-3-methoxy-5,6,8,8a,9,10,11,12a,13,13a-decahydroisoquinolino[2,1-g][1,6]naphthyridine L204 45.52x52 ECL2 hydrophobic
(8Ar,12aS,13aR)-12-ethylsulfonyl-3-methoxy-5,6,8,8a,9,10,11,12a,13,13a-decahydroisoquinolino[2,1-g][1,6]naphthyridine F398 6.51x51 TM6 hydrophobic
(8Ar,12aS,13aR)-12-ethylsulfonyl-3-methoxy-5,6,8,8a,9,10,11,12a,13,13a-decahydroisoquinolino[2,1-g][1,6]naphthyridine F399 6.52x52 TM6 hydrophobic
(8Ar,12aS,13aR)-12-ethylsulfonyl-3-methoxy-5,6,8,8a,9,10,11,12a,13,13a-decahydroisoquinolino[2,1-g][1,6]naphthyridine Y402 6.55x55 TM6 hydrophobic
(8Ar,12aS,13aR)-12-ethylsulfonyl-3-methoxy-5,6,8,8a,9,10,11,12a,13,13a-decahydroisoquinolino[2,1-g][1,6]naphthyridine F423 7.39x38 TM7 hydrophobic

Ligands

(8Ar,12aS,13aR)-12-ethylsulfonyl-3-methoxy-5,6,8,8a,9,10,11,12a,13,13a-decahydroisoquinolino[2,1-g][1,6]naphthyridine

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Residue Diagrams

V N G V V T F V I L F G V V A A L G A V 1 V S L A S A D I L V A L T V M P F S L A N 2 A C L H V I S S T C F L V D L A L Y V G 3 V K A T I V A V W L I S A V I S F P P L 4 Y V L G M I L C P A F F S G I C S S L I Y 5 A V V M G V F V L C W F P F F F S Y S L 6 V P N L S S N C Y G I W F F F K F L P 7
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ICL1 R A L R ICL1ECL1 Y W Y F ECL1ICL2 A V E Y N L K R ICL2ECL2 S L Y R Q P D G A A Y P Q C G L N D ECL2ICL3 R A P V G P D G A S P T T E N G L G A A A G A G E N G H C A P P P A D V E P D E S S A A A E R R R R R G A L R R G G R R R A G A E G G A G G A D G Q G A G P G A A E S G A L T A S R S P G P G G R L S R A S S R S V E F F L S R R R R A R S S V C R R ICL3ECL3 E A C Q V ECL3N-term M A S P A L A A A L A V A A A A G P N A S G A G E R G S G G V A N A S G A S W G P P R G Q Y N-termC-term R R R R R G F R Q C-term S A G A V A G L A A V V G F L I V F T V V G N V L V V I A V L T S A P Q N L F L V S L A S A D I L V A T L V M P F S L A N E L M A G Q V W C G V Y L A L D V L F C T S S I V H L C A I S L D R Y W S V T Q T P R R V K A T I V A V W L I S A V I S F P P L V E T W Y I L S S C I G S F F A P C L I M G L V Y A R I Y R V A K L R T R T L S E K K V A Q A R E K R F T F V L A V V M G V F V L C W F P F F F S Y S L Y G I C R P G P L F K F F F W I G Y C N S S L N P V I Y T V F N Q D F K H F R R S I L F
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Residue Table


GPCRdb(A)
GPCRdb(A)
α2C-adrenoceptor
TM3
3x32 3.32x32 D131
3x33 3.33x33 V132
3x36 3.36x36 C135
ECL2
45x52 45.52x52 L204
TM6
6x51 6.51x51 F398
6x52 6.52x52 F399
6x55 6.55x55 Y402
TM7
7x38 7.39x38 F423