PDB
6LMK
Resolution
3.7 Å
Released
April 1, 2020
Receptor
glucagon
Class
B1
Species
Homo sapiens
Ligand
Function
Glucagon
Agonist
Reference
10.1126/SCIENCE.AAZ5346

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Ligand Amino Acid Generic Number Segment Interaction Type
Glucagon Q27 N-term polar (charge-charge)
Glucagon Q27 N-term polar (hydrogen bond with backbone)
Glucagon V28 N-term polar (hydrogen bond with backbone)
Glucagon M29 N-term hydrophobic
Glucagon L32 N-term hydrophobic
Glucagon F33 N-term hydrophobic
Glucagon W36 N-term Van der Waals
Glucagon K64 N-term polar (charge-charge)
Glucagon K64 N-term polar (hydrogen bond)
Glucagon K64 N-term aromatic (pi-cation)
Glucagon Y65 N-term hydrophobic
Glucagon Y84 N-term Van der Waals
Glucagon W87 N-term hydrophobic
Glucagon R116 N-term Van der Waals
Glucagon A118 N-term hydrophobic
Glucagon Q122 N-term Van der Waals
Glucagon M123 N-term Van der Waals
Glucagon Q131 1.29x29 TM1 polar (hydrogen bond)
Glucagon Q131 1.29x29 TM1 polar (hydrogen bond)
Glucagon V134 1.32x32 TM1 Van der Waals
Glucagon A135 1.33x33 TM1 Van der Waals
Glucagon Y138 1.36x36 TM1 aromatic (edge-to-face)
Glucagon Y138 1.36x36 TM1 hydrophobic
Glucagon F141 1.39x39 TM1 hydrophobic
Glucagon Q142 1.40x40 TM1 polar (hydrogen bond)
Glucagon Q142 1.40x40 TM1 polar (hydrogen bond)
Glucagon Y145 1.43x43 TM1 hydrophobic
Glucagon Y149 1.47x47 TM1 Van der Waals
Glucagon V191 2.64x64 TM2 hydrophobic
Glucagon L198 2.71x71 TM2 Van der Waals
Glucagon R201 2.74x74 TM2 polar (hydrogen bond with backbone)
Glucagon Y202 2.75x75 TM2 hydrophobic
Glucagon Q204 ECL1 Van der Waals
Glucagon I206 ECL1 hydrophobic
Glucagon G207 ECL1 Van der Waals
Glucagon D208 ECL1 Van der Waals
Glucagon V212 ECL1 hydrophobic
Glucagon W215 ECL1 aromatic (pi-cation)
Glucagon M231 3.36x36 TM3 Van der Waals
Glucagon I235 3.40x40 TM3 hydrophobic
Glucagon I235 3.40x40 TM3 polar (hydrogen bond with backbone)
Glucagon Q293 ECL2 Van der Waals
Glucagon T296 45.52x52 ECL2 Van der Waals
Glucagon S297 ECL2 Van der Waals
Glucagon N298 ECL2 polar (hydrogen bond with backbone)
Glucagon W304 5.36x37 TM5 Van der Waals
Glucagon R308 5.40x40 TM5 hydrophobic
Glucagon V311 5.43x43 TM5 Van der Waals
Glucagon D370 ECL3 hydrophobic
Glucagon R378 7.35x34 TM7 polar (charge-charge)
Glucagon K381 7.38x37 TM7 Van der Waals
Glucagon L382 7.39x38 TM7 Van der Waals
Glucagon D385 7.42x41 TM7 polar (charge-charge)
Glucagon L386 7.43x42 TM7 Van der Waals

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ICL1 S K L H ICL1ECL1 Q K I G D D L S V S T W L S D G ECL1ICL2 A T L P E R ICL2ECL2 N V Q C W T S N D N M G F ECL2ICL3 R Q M H H T ICL3ECL3 E H A Q ECL3N-term M P P C Q P Q R P L L L L L L L L A C Q P Q V P S A Q V M D F L F E K W K L Y G D Q C H H N L S L L P P P T E L V C N R T F D K Y S C W P D T P A N T T A N I S C P W Y L P W H H K V Q H R F V F K R C G P D G Q W V R G P R G Q P W R D A S Q C Q M D G E E I E V N-termC-term T S N H R A S S S P G H G P P S K E L Q F G R G G G S Q D S S A E T P L A G G L P R L A E S P F C-term Q K E V A K M Y S S F Q V M Y T V G Y S L S L G A L L L A L A I L G G L C T R N A I H A N L F A S F V L K A S S V L V I D G L L R T R Y S A V A G C R V A A V F M Q Y G I V A N Y C W L L V E G L Y L H N L L G L S F F S L Y L G I G W G A P M L F V V P W A V V K C L F E W W I L R F P V F L A I L I N F F I F V R I V Q L L V A K L R A D Y K F R L A K S T L T L I P L L G V H E V V F A F V T D G T L R S A K L F F D L F L S S F Q G L L V A V L Y C F L N K E L R R W R L W E E V Q S E R W H R G K V L R N
Helix box plot — Download: PNG | SVG L L A G L S L S Y G V T Y M V Q F S S Y 1 A N L F A S F V L K A S S V L V I D G L 2 V L L W C Y N A V I G Y Q M F V A A V R 3 F F S L Y L G G I W G A P M L F V V P W A 4 F I F F N I L I A L F V P F R L I W W 5 L T L I P L L G V H E V V F A F V T D 6 V A V L L G Q F S S L F L D F F L K A 7

GPCRdb(A)
GPCRdb(B)
glucagon receptor
TM1
1x25 1.29x29 Q131
1x28 1.32x32 V134
1x29 1.33x33 A135
1x32 1.36x36 Y138
1x35 1.39x39 F141
1x36 1.40x40 Q142
1x39 1.43x43 Y145
1x43 1.47x47 Y149
TM2
2x57 2.64x64 V191
2x64 2.71x71 L198
2x67 2.74x74 R201
2x68 2.75x75 Y202
TM3
3x32 3.36x36 M231
3x36 3.40x40 I235
ECL2
45x52 45.52x52 T296
TM5
5x41 5.36x37 W304
5x44 5.40x40 R308
5x47 5.43x43 V311
TM7
7x30 7.35x34 R378
7x33 7.38x37 K381
7x34 7.39x38 L382
7x37 7.42x41 D385
7x38 7.43x42 L386