Structure information

PAC1 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

6LPB

SPECIES

Homo sapiens

RESOLUTION

3.900

PREFERRED CHAIN

R

PUBLICATION DATE

March 11, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
PACAP F27 N-term hydrophobic
PACAP N60 N-term polar (hydrogen bond with backbone)
PACAP I61 N-term hydrophobic
PACAP I83 N-term hydrophobic
PACAP Y150 1.36x36 TM1 polar (hydrogen bond)
PACAP V153 1.39x39 TM1 hydrophobic
PACAP K154 1.40x40 TM1 polar (charge-assisted hydrogen bond)
PACAP Y157 1.43x43 TM1 aromatic (edge-to-face)
PACAP Y161 1.47x47 TM1 polar (charge-assisted hydrogen bond)
PACAP K206 2.67x67 TM2 polar (charge-assisted hydrogen bond)
PACAP L210 2.71x71 TM2 polar (hydrogen bond with backbone)
PACAP Y211 2.72x72 TM2 aromatic (face-to-edge)
PACAP V237 3.40x40 TM3 hydrophobic
PACAP D298 45.52x52 ECL2 polar (charge-assisted hydrogen bond)
PACAP W306 5.36x37 TM5 aromatic (edge-to-face)
PACAP L382 7.39x38 TM7 hydrophobic
PACAP E385 7.42x41 TM7 polar (charge-assisted hydrogen bond)
PACAP L386 7.43x42 TM7 hydrophobic

Ligands

PACAP

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Residue Diagrams

T L T V L S T S Y G V T Y L A K V S L Y 1 M N L F V S F M L R A I S V F I K D W I 2 I F L W F Y N S V V C Y H F F V M V A K 3 Y F Y W Y T I G I W G T P T V C V T V W A 4 F L V F N V M I S G V V P G K I V W W L A 5 L L L I P L F G I H Y T V F A F S 6 V A V V F G Q F S G L G L E F V L R E 7
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ICL1 R K L H ICL1ECL1 Y A E Q D S N H C F I S ECL1ICL2 T F F P E R ICL2ECL2 D T G C W D M N D ECL2ICL3 Q S P D M G G ICL3ECL3 P E N V S ECL3N-term M A G V V H V S L A A L L L L P M A P A M H S D C I F K K E Q A M C L E K I Q R A N E L M G F N D S S P G C P G M W D N I T C W K P A H V G E M V L V S C P E L F R I F N P D Q V W E T E T I G E S D F G D S N S L D L S D M G V V S R N C T E D G W S E P F P H Y F D A C G F D E N-termC-term H R H P S L A S S G V N G G T Q L S I L S K S S S Q I R M S G L P A D N L A T C-term Y E S E T G D Q D Y Y Y L S V K A L Y T V G Y S T S L V T L T T A M V I L C R F C T R N F I H M N L F V S F M L R A I S V F I K D W I L T V E C K A V M V F F H Y C V V S N Y F W L F I E G L Y L F T L L V E R Y F Y W Y T I I G W G T P T V C V T V W A T L R L Y F D S T A L W W V I K G P V V G S I M V N F V L F I G I I V I L V Q K L N E S S I Y L R L A R S T L L L I P L F G I H Y T V F A F S K R E R L V F E L G L G S F Q G F V V A V L Y C F L N G E I K R W K V A V D V Q A E K W R S N R Y F F K
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Residue Table


GPCRdb(A)
GPCRdb(B)
PAC1 receptor
TM1
1x32 1.36x36 Y150
1x35 1.39x39 V153
1x36 1.40x40 K154
1x39 1.43x43 Y157
1x43 1.47x47 Y161
TM2
2x60 2.67x67 K206
2x64 2.71x71 L210
TM3
3x36 3.40x40 V237
ECL2
45x52 45.52x52 D298
TM5
5x41 5.36x37 W306
TM7
7x34 7.39x38 L382
7x37 7.42x41 E385
7x38 7.43x42 L386