Structure information

D2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6LUQ

SPECIES

Homo sapiens

RESOLUTION

3.100

PREFERRED CHAIN

A

PUBLICATION DATE

March 4, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Haloperidol L94 2.64x63 TM2 hydrophobic
Haloperidol F110 3.28x28 TM3 hydrophobic
Haloperidol D114 3.32x32 TM3 polar (charge-charge)
Haloperidol C118 3.36x36 TM3 hydrophobic
Haloperidol I184 45.52x52 ECL2 hydrophobic
Haloperidol F198 5.47x47 TM5 hydrophobic
Haloperidol W407 6.48x48 TM6 aromatic (face-to-edge)
Haloperidol F410 6.51x51 TM6 hydrophobic
Haloperidol F411 6.52x52 TM6 aromatic (edge-to-face)
Haloperidol Y429 7.35x34 TM7 polar (hydrogen bond)

Ligands

Haloperidol

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Residue Diagrams

V N G F V I V A I L L T L L T A Y Y N Y 1 V S L A V A D L L V A L T V M P W V V Y L 2 A C L N L I S A T C M M V D L T V F I D 3 V T V M I S I V W V L S F T I S C P L 4 Y V L L T V I F P V Y F S V I S S Y V V F 5 A I V L G V F I I C W L P F F I T H I L 6 I P N V A S N V Y G L W T F A S Y L V 7
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ICL1 K A L Q ICL1ECL1 E W K F ECL1ICL2 P M L Y N T R Y S ICL2ECL2 G L N N A D Q N E C I I A ECL2ICL3 R S S R A F R A H L R A P L K G N C T H P E D M K L C T V I M K S N G S F P V N R R R V E A A R R A Q E L E M E M L S S T S P P E R T R Y S P I P P S H H Q L T L P D P S H H G L H S T P D S P A K P E K N G H A K D H P K I A K I F E I Q T M P N G K T R T S L K T M S R R ICL3ECL3 D C N I ECL3N-term M D P L N L S W Y D D D L E R Q N W S R P F N G S D G K A D N-termC-term C C-term R P H Y N Y Y A T L L T L L I A V I V F G N V L V C M A V S R E T T T N Y L I V S L A V A D L L V A T L V M P W V V Y L E V V G S R I H C D I F V T L D V M M C T A S I L N L C A I S I D R Y T A V A M S K R R V T V M I S I V W V L S F T I S C P L L F N P A F V V Y S S I V S F Y V P F I V T L L V Y I K I Y I V L R R R R K R V N T K K L S Q Q K E K K A T Q M L A I V L G V F I I C W L P F F I T H I L N I H C P P V L Y S A F T W L G Y V N S A V N P I I Y T T F N I E F L K F R K A I L H
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Residue Table


GPCRdb(A)
GPCRdb(A)
D2 receptor
TM2
2x63 2.64x63 L94
TM3
3x28 3.28x28 F110
3x32 3.32x32 D114
3x36 3.36x36 C118
ECL2
45x52 45.52x52 I184
TM5
5x47 5.47x47 F198
TM6
6x48 6.48x48 W386
6x51 6.51x51 F389
6x52 6.52x52 F390
TM7
7x34 7.35x34 Y408