Structure information

PAC1 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

6M1H

SPECIES

Homo sapiens

RESOLUTION

3.600

PREFERRED CHAIN

A

REFERENCE

10.1038/S41422-020-0280-2

PUBLICATION DATE

March 11, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
maxadilan I61 N-term hydrophobic
maxadilan L80 N-term hydrophobic
maxadilan F84 N-term hydrophobic
maxadilan Y130 N-term hydrophobic
maxadilan F131 N-term hydrophobic
maxadilan F136 N-term hydrophobic
maxadilan D147 1.33x33 TM1 polar (charge-assisted hydrogen bond)
maxadilan Y150 1.36x36 TM1 polar (hydrogen bond)
maxadilan Y150 1.36x36 TM1 Van der Waals
maxadilan Y150 1.36x36 TM1 polar (hydrogen bond)
maxadilan K154 1.40x40 TM1 Van der Waals
maxadilan Y157 1.43x43 TM1 Van der Waals
maxadilan Y157 1.43x43 TM1 hydrophobic
maxadilan V203 2.64x64 TM2 hydrophobic
maxadilan Y211 2.72x72 TM2 Van der Waals
maxadilan Y211 2.72x72 TM2 hydrophobic
maxadilan Q214 2.75x75 TM2 Van der Waals
maxadilan Q214 2.75x75 TM2 polar (hydrogen bond with backbone)
maxadilan H218 ECL1 Van der Waals
maxadilan C219 ECL1 Van der Waals
maxadilan C219 ECL1 polar (hydrogen bond with backbone)
maxadilan F220 ECL1 Van der Waals
maxadilan F220 ECL1 aromatic (face-to-edge)
maxadilan F233 3.36x36 TM3 hydrophobic
maxadilan F233 3.36x36 TM3 Van der Waals
maxadilan Y241 3.44x44 TM3 polar (hydrogen bond)
maxadilan M299 ECL2 hydrophobic
maxadilan M299 ECL2 Van der Waals
maxadilan N300 ECL2 polar (hydrogen bond)
maxadilan N300 ECL2 Van der Waals
maxadilan N300 ECL2 polar (hydrogen bond)
maxadilan D301 ECL2 polar (charge-assisted hydrogen bond)
maxadilan W306 5.36x37 TM5 Van der Waals
maxadilan W306 5.36x37 TM5 hydrophobic
maxadilan V313 5.43x43 TM5 hydrophobic
maxadilan V313 5.43x43 TM5 Van der Waals
maxadilan A370 6.57x57 TM6 hydrophobic
maxadilan A370 6.57x57 TM6 Van der Waals
maxadilan E374 ECL3 polar (charge-assisted hydrogen bond)
maxadilan R379 ECL3 polar (charge-assisted hydrogen bond)
maxadilan R381 ECL3 Van der Waals
maxadilan L382 7.39x38 TM7 Van der Waals
maxadilan L382 7.39x38 TM7 hydrophobic
maxadilan E385 7.42x41 TM7 Van der Waals
maxadilan L386 7.43x42 TM7 Van der Waals
maxadilan L386 7.43x42 TM7 hydrophobic

Ligands

maxadilan

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Residue Diagrams

T L T V L S T S Y G V T Y L A K V S L Y 1 M N L F V S F M L R A I S V F I K D W I 2 I F L W F Y N S V V C Y H F F V M V A K 3 Y F Y W Y T I G I W G T P T V C V T V W A 4 F L V F N V M I S G V V P G K I V W W L A 5 L L L I P L F G I H Y T V F A F S 6 V A V V F G Q F S G L G L E F V L R E 7
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ICL1 R K L H ICL1ECL1 Y A E Q D S N H C F I S ECL1ICL2 T F F P E R ICL2ECL2 D T G C W D M N D ECL2ICL3 Q S P D M G G ICL3ECL3 P E N V S ECL3N-term M A G V V H V S L A A L L L L P M A P A M H S D C I F K K E Q A M C L E K I Q R A N E L M G F N D S S P G C P G M W D N I T C W K P A H V G E M V L V S C P E L F R I F N P D Q V W E T E T I G E S D F G D S N S L D L S D M G V V S R N C T E D G W S E P F P H Y F D A C G F D E N-termC-term H R H P S L A S S G V N G G T Q L S I L S K S S S Q I R M S G L P A D N L A T C-term Y E S E T G D Q D Y Y Y L S V K A L Y T V G Y S T S L V T L T T A M V I L C R F C T R N F I H M N L F V S F M L R A I S V F I K D W I L T V E C K A V M V F F H Y C V V S N Y F W L F I E G L Y L F T L L V E R Y F Y W Y T I I G W G T P T V C V T V W A T L R L Y F D S T A L W W V I K G P V V G S I M V N F V L F I G I I V I L V Q K L N E S S I Y L R L A R S T L L L I P L F G I H Y T V F A F S K R E R L V F E L G L G S F Q G F V V A V L Y C F L N G E I K R W K V A V D V Q A E K W R S N R Y F F K
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Residue Table


GPCRdb(A)
GPCRdb(B)
PAC1 receptor
TM1
1x29 1.33x33 D147
1x32 1.36x36 Y150
1x36 1.40x40 K154
1x39 1.43x43 Y157
TM2
2x57 2.64x64 V203
TM3
3x32 3.36x36 F233
3x40 3.44x44 Y241
TM5
5x41 5.36x37 W306
5x47 5.43x43 V313
TM6
6x52 6.57x57 A370
TM7
7x34 7.39x38 L382
7x37 7.42x41 E385
7x38 7.43x42 L386