Structure information

EP3 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6M9T

SPECIES

Homo sapiens

RESOLUTION

2.500

PREFERRED CHAIN

A

PUBLICATION DATE

Dec. 5, 2018

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
misoprostol-FA Y114 2.65x64 TM2 polar (charge-assisted hydrogen bond)
misoprostol-FA M137 3.32x32 TM3 hydrophobic
misoprostol-FA T206 ECL2 polar (charge-assisted hydrogen bond)
misoprostol-FA W207 ECL2 hydrophobic
misoprostol-FA L329 7.36x35 TM7 hydrophobic
misoprostol-FA R333 7.40x39 TM7 polar (charge-charge)
misoprostol-FA Q339 7.46x46 TM7 polar (hydrogen bond)

Ligands

misoprostol-FA

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Residue Diagrams

A N G V F G T L L M T I P F A V 1 G W L A L T D L V G Q L L T T P V V I V V 2 A S A I F L S S L G F V T M T L G F F T 3 T R A V L L G V W L A V L A F A L L P V 4 N C S F T V T L A L L G L F A F A S A F 5 M G I M C V L S V C W S P L L I M M L K 6 W P D L I Q N L S A L R V A I L F F N 7
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ICL1 R R E S K R K ICL1ECL1 Q R W E H ECL1ICL2 P H W Y A S H M ICL2ECL2 V G Q Y T V Q W P G T W C F I S T G R G G N G T S S S H N ECL2ICL3 T A S Q ICL3ECL3 V E H C K ECL3N-term M K E T R G Y G G D A P F C T R L N H S Y T G M W A P E R S A E A R G N L T R P P G S G E D C G S V S N-termC-term S S T S L P C Q C S S T L M W S D H L E R C-term V A F P I T M L L T G F V G N A L A M L L V S R S Y R K S F L L C I G W L A L T D L V G Q L L T T P V V I V V Y L S K I D P S G R L C T F F G L T M T V F G L S S L F I A S A M A V E R A L A I R A K T R A T R A V L L G V W L A V L A F A L L P V L G W G N L F F A S A F A F L G L L A L T V T F S C N L A T I K A L V S R C R A K A S S A Q W G R I T T E T A I Q L M G I M C V L S V C W S P L L I M M L K M I F N Q T S T H T E K Q K E C N F F L I A V R L A S L N Q I L D P W V Y L L L L R K R Y H A S R K I L F C Q I T N N Y
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Residue Table


GPCRdb(A)
GPCRdb(A)
EP3 receptor
TM2
2x64 2.65x64 Y114
TM3
3x32 3.32x32 M137
TM7
7x35 7.36x35 L329
7x39 7.40x39 R333
7x46 7.46x46 Q339