Structure information

MT1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6ME5

SPECIES

Homo sapiens

RESOLUTION

3.200

PREFERRED CHAIN

A

PUBLICATION DATE

April 24, 2019

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Agomelatine M107 3.32x32 TM3 hydrophobic
Agomelatine N162 4.60x61 TM4 polar (hydrogen bond)
Agomelatine F179 45.52x52 ECL2 hydrophobic
Agomelatine Q181 ECL2 polar (hydrogen bond)
Agomelatine L254 6.51x51 TM6 hydrophobic

Ligands

Agomelatine

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Residue Diagrams

L N G L I D V V I T F I L V C A L A S A 1 V S L A V A D L V V A Y I P Y P L V L M S 2 G T I N F I S G I V S L G M L F G S V Q 3 S L C Y V L L I W L L T L A A V L P N 4 Y C F I V I I M P V L F H F V V V A I T Y 5 F V V F V L F A I C W A P L N F I G L A 6 I A N L C S N F Y A M Y Y S A V F L W 7
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ICL1 K K L R ICL1ECL1 G W N L ECL1ICL2 S L K Y D K L Y ICL2ECL2 T L Q Y D P R I Y S C T F A Q S V ECL2ICL3 K P D R K ICL3ECL3 P A S M V P R I ECL3N-term M Q G N G S A L P N A S Q P V L R G D G A R N-termC-term A R V F F V D S S N D V A D R V K W K P S P L M T N N N V V K V D S V C-term P S W L A S A L A C V L I F T I V V D I L G N L L V I L S V Y R N N A G N I F V V S L A V A D L V V A I Y P Y P L V L M S I F N N G Y L H C Q V S G F L M G L S V I G S I F N I T G I A I N R Y C Y I C H S S K N S L C Y V L L I W L L T L A A V L P N L R A G S S A Y T I A V V V F H F L V P M I I V I F C Y L R I W I L V L Q V R Q R V P K L K P Q D F R N F V T M F V V F V L F A I C W A P L N F I G L A V A S D P E W L F V A S Y Y M A Y F N S C L N A I I Y G L L N Q N Y R R L C T F R K E I I V S
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Residue Table


GPCRdb(A)
GPCRdb(A)
MT1 receptor
TM3
3x32 3.32x32 M107
TM4
4x61 4.60x61 N162
ECL2
45x52 45.52x52 F179
TM6
6x51 6.51x51 L254