Structure information

MT2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6ME6

SPECIES

Homo sapiens

RESOLUTION

2.800

PREFERRED CHAIN

B

PUBLICATION DATE

April 24, 2019

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
2-Phenylmelatonin M120 3.32x32 TM3 hydrophobic
2-Phenylmelatonin V124 3.36x36 TM3 hydrophobic
2-Phenylmelatonin I125 3.37x37 TM3 hydrophobic
2-Phenylmelatonin N175 4.60x61 TM4 polar (hydrogen bond)
2-Phenylmelatonin F192 45.52x52 ECL2 aromatic (face-to-face)
2-Phenylmelatonin Q194 ECL2 polar (hydrogen bond)
2-Phenylmelatonin F264 6.48x48 TM6 hydrophobic
2-Phenylmelatonin L267 6.51x51 TM6 hydrophobic
2-Phenylmelatonin Y294 7.39x38 TM7 aromatic (face-to-face)
2-Phenylmelatonin Y298 7.43x42 TM7 hydrophobic

Ligands

2-Phenylmelatonin

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Residue Diagrams

L N G V V D V A T T V I L V A S L A P A 1 V S L A L A D L V V A Y F P Y P L I L V A 2 A T I N F V S G I V S L G M V F A S A K 3 T P L H I C L I W L L T V V A L L P N 4 Y C F S V V A I P L L F H I V V V A A T Y 5 F V V F V I F A I C W A P L N C I G L A 6 I A N L C S N F Y A L L Y S T V F L G 7
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ICL1 R K L R ICL1ECL1 G W A L ECL1ICL2 S M A Y H R I Y ICL2ECL2 S L E Y D P R I Y S C T F I Q T A ECL2ICL3 K P E S R ICL3ECL3 P Q E M A P Q I ECL3N-term M S E N G S F A N C C E A G G W A V R P G W S G A G S A R P S R T P R P P N-termC-term P R H C I Q D A S K G S H A E G L Q S P A P P I I G V Q H Q A D A L C-term W V A P A L S A V L I V T T A V D V V G N L L V I L S V L R N N A G N L F L V S L A L A D L V V A F Y P Y P L I L V A I F Y D G E E H C K A S A F V M G L S V I G S V F N I T A I A I N R Y C Y I C H R R W H T P L H I C L I W L L T V V A L L P N F F V G S T Q Y T A A V V V I H F L L P I A V V S F C Y L R I W V L V L Q A R R K A L C L K P S D L R S F L T M F V V F V I F A I C W A P L N C I G L A V A I N P E G L F V T S Y L L A Y F N S C L N A I V Y G L L N Q N Y K R L W N F R R E I L L A
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Residue Table


GPCRdb(A)
GPCRdb(A)
MT2 receptor
TM3
3x32 3.32x32 M120
3x36 3.36x36 V124
3x37 3.37x37 I125
TM4
4x61 4.60x61 N175
ECL2
45x52 45.52x52 F192
TM6
6x48 6.48x48 W264
6x51 6.51x51 L267
TM7
7x38 7.39x38 Y294
7x42 7.43x42 Y298