Structure information

CB1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6N4B

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

R

REFERENCE

10.1016/J.CELL.2018.11.040

PUBLICATION DATE

Jan. 30, 2019

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
MDMB-Fubinaca F170 2.57x57 TM2 hydrophobic
MDMB-Fubinaca F174 2.61x61 TM2 hydrophobic
MDMB-Fubinaca F177 2.64x64 TM2 hydrophobic
MDMB-Fubinaca H178 2.65x65 TM2 Van der Waals
MDMB-Fubinaca H178 2.65x65 TM2 polar (hydrogen bond)
MDMB-Fubinaca V196 3.32x32 TM3 Van der Waals
MDMB-Fubinaca V196 3.32x32 TM3 hydrophobic
MDMB-Fubinaca T197 3.33x33 TM3 Van der Waals
MDMB-Fubinaca F200 3.36x36 TM3 aromatic (edge-to-face)
MDMB-Fubinaca F200 3.36x36 TM3 Van der Waals
MDMB-Fubinaca F268 ECL2 Van der Waals
MDMB-Fubinaca F268 ECL2 aromatic (face-to-edge)
MDMB-Fubinaca F379 7.35x34 TM7 hydrophobic

Ligands

MDMB-Fubinaca

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Residue Diagrams

L N E L V T F T G L T L S L V A I A L Q 1 G S L A V A D L L G S V I F V Y S F I D 2 L F L S G V S A T F S A T V G G L K F L 3 A V V A F C L M W T I A I V I A V L P L 4 Y A Y V I F L L L V S T V G I W F M L Y 5 V L I L V V L I I C W G P L L A I M V Y 6 I P N V T S N L L C L M S C F A F V T 7
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ICL1 R S L R C ICL1ECL1 F H R K D ECL1ICL2 P L A Y K R I V ICL2ECL2 W N C E K L Q S V C S D I F P H I ECL2ICL3 T Q K S I I I H T S E D G K V Q V T R ICL3ECL3 K M ECL3N-term M K S I L D G L A D T T F R T I T T D L L Y V G S N D I Q Y E D I K G D M A S K L G Y F P Q K F P L T S F R G S P F Q E K M T A G D N P Q L V P A D Q V N I T E F Y N K S L S S F K E N E E N I Q C G E N F M D I E C F M V L N-termC-term S C E G T A Q P L D N S M G D S D C L H K H A N N A A S V H R A A E S C I K S T V K I A K V T M S V S T D T S A E A L C-term N P S Q Q L A I A V L S L T L G T F T V L E N L L V L C V I L H S R P S Y H F I G S L A V A D L L G S V I F V Y S F I D F H V S R N V F L F K L G G V T A S F T A S V G S L F L T A I D R Y I S I H R T R P K A V V A F C L M W T I A I V I A V L P L L G D E T Y L M F W I G V T S V L L L F I V Y A Y M Y I L W K A H S H A V R M I Q R G P D Q A R M D I R L A K T L V L I L V V L I I C W G P L L A I M V Y D V F G N K L I K T V F A F C S M L C L L N S T V N P I I Y A L R S K D F R S L R H A M F P
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Residue Table


GPCRdb(A)
GPCRdb(A)
CB1 receptor
TM2
2x57 2.57x57 F170
2x61 2.61x61 F174
2x64 2.64x64 F177
2x65 2.65x65 H178
TM3
3x32 3.32x32 V196
3x33 3.33x33 T197
3x36 3.36x36 F200
TM7
7x34 7.35x34 F379