Structure information

SMO

PROTEIN CLASS

Class F (Frizzled)

PDB CODE

6O3C

SPECIES

Mus musculus

RESOLUTION

2.800

PREFERRED CHAIN

A

REFERENCE

10.1038/S41586-019-1355-4

PUBLICATION DATE

July 3, 2019

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
SAG21k L225 N-term hydrophobic
SAG21k M305 ECL1 hydrophobic
SAG21k Y398 ECL2 hydrophobic
SAG21k W484 6.61x61 TM6 Van der Waals
SAG21k W484 6.61x61 TM6 polar (hydrogen bond with backbone)
SAG21k E485 6.62x62 TM6 Van der Waals
SAG21k E485 6.62x62 TM6 polar (hydrogen bond with backbone)
SAG21k F488 6.65x65 TM6 Van der Waals
SAG21k F488 6.65x65 TM6 hydrophobic
SAG21k P517 ECL3 Van der Waals
SAG21k P517 ECL3 hydrophobic
SAG21k E522 7.38x38 TM7 polar (charge-assisted hydrogen bond)

Ligands

SAG21k

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Residue Diagrams

L T C L G T V A G F A A I Y S H M D Q H 1 F Y V N A C F F V G S I G W L A Q F 2 V V F W V V G A M L A Y Y V I V F I I V 3 T S Y F H L L T W S L P F V L T V A I L 4 L F Y G G V I L V L G I P A L V F G A R Y 5 G I F G F L A F G F V L I T F S C H F Y 6 T S M A I G T G F M A F L N I K E V L L 7
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ICL1 W R N S N ICL1ECL1 M D G A R R E I V C R A D G T M R F G E P T S S E T ECL1ICL2 L G T T Y Q P L S G ICL2ECL2 Q V D G D S V S G I C F V G Y K ECL2ICL3 P G L L ICL3ECL3 G L P T K K P I P D C E I K N R P ECL3N-term M A A G R P V R G P E L A P R R L L Q L L L L V L L G G P G R G A A L S G N V T G P G P H S A S G S S R R D V P V T S P P P P L L S H C G R A A H C E P L R Y N V C L G S A L P Y G A T T T L L A G D S D S Q E E A H G K L V L W S G L R N A P R C W A V I Q P L L C A V Y M P K C E N D R V E L P S R T L C Q A T R G P C A I V E R E R G W P D F L R C T P D H F P E G C P N E V Q N I K F N S S G Q C E A P L V R T D N P K S W Y E D V E G C G I Q C Q N P L F N-termC-term G H S D D E P K R I K K S K M I A K A F S K R R E L L Q N P G Q E L S F S M H T V S H D G P V A G L A F D L N E P S A D V S S A W A Q H V T K M V A R R G A I L P Q D V S V T P V A T P V P P E E Q A N M W L V E A E I S P E L E K R L G R K K K R R K R K K E V C P L R P A P E L H H S A P V P A T S A V P R L P Q L P R Q K C L V A A N A W G T G E S C R Q G A W T L V S N P F C P E P S P H Q D P F L P G A S A P R V W A Q G R L Q G L G S I H S R T N L M E A E I L D A D S D F C-term T E A E H Q D M H S Y I A A F G A V T G L C T L F T L A T F V A D R Y P A V I L F Y V N A C F F V G S I G W L A Q F L S C V I I F V I V Y Y A L M A G V V W F V V L T Y A W H T S F K A K T S Y F H L L T W S L P F V L T V A I L A V A N Y R Y R A G F V L A P I G L V L I V G G Y F L I R G V M T L F S I K S N H S E K A A S K I N E T M L R L G I F G F L A F G F V L I T F S C H F Y D F F N Q A E W E R S F R D Y V L C Q A N V T I S L L V E K I N L F A M F G T G I A M S T W V W T K A W R R L T T L L I T W C R
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Residue Table


GPCRdb(A)
GPCRdb(F)
SMO
TM6
6x65 6.61x61 W484
6x66 6.62x62 E485
6x69 6.65x65 F488
TM7
7x35 7.38x38 E522