Structure information

M2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6OIK

SPECIES

Homo sapiens

RESOLUTION

3.600

PREFERRED CHAIN

R

PUBLICATION DATE

May 8, 2019

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
LY2119620 Y80 2.61x60 TM2 polar (hydrogen bond)
LY2119620 Y83 2.64x63 TM2 hydrophobic
iperoxo Y104 3.33x33 TM3 hydrophobic
LY2119620 Y177 45.51x51 ECL2 hydrophobic
iperoxo A194 5.46x461 TM5 hydrophobic
iperoxo W400 6.48x48 TM6 hydrophobic
iperoxo Y403 6.51x51 TM6 hydrophobic
iperoxo N404 6.52x52 TM6 polar (hydrogen bond)
LY2119620 N419 7.32x31 TM7 polar (hydrogen bond)
LY2119620 W422 7.35x34 TM7 aromatic (face-to-face)
iperoxo Y426 7.39x38 TM7 hydrophobic
iperoxo C429 7.42x41 TM7 hydrophobic
iperoxo Y430 7.43x42 TM7 hydrophobic

Ligands

LY2119620

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iperoxo

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Residue Diagrams

I N G I I T V L S L S G A V L V I F V V 1 F S L A C A D L I I G F V S M N L Y T L Y 2 I L L N M V S A N S V V Y D L A L W L D 3 A G M M I A A A W V L S F I L W A P A I 4 Y L V T M I I V P L Y F A A I A T G F T V 5 L A I L L A F I I T W A P Y N V M V L I 6 A P N I T S N I Y C L W Y G I T W V T 7
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ICL1 R H L Q ICL1ECL1 Y W P L ECL1ICL2 P L T Y P V K R ICL2ECL2 V R T V E D G E C Y I Q F F S ECL2ICL3 P V A N Q D P V S P S L V Q G R I V K P N N N N M P S S D D G L E H N K I Q N G K A P R D P V T E N C V Q G E E K E S S N D S T S V S A V A S N M R D D E I T Q D E N T V S T S L G H S K D E N S K Q T C I R I G T K T P K S D S C T P T N T T V E V V G S S G Q N G D E K Q N I V A R K I V K M T K Q P A K K ICL3ECL3 A P C I ECL3N-term M N N S T N S S N N S L A L T S P Y N-termC-term C H Y K N I G A T R C-term K T F E V V F I V L V A G S L S L V T I I G N I L V M V S I K V N T V N N Y F L F S L A C A D L I I G V F S M N L Y T L Y T V I G G P V V C D L W L A L D Y V V S N A S V M N L L I I S F D R Y F C V T K T T K M A G M M I A A A W V L S F I L W A P A I L F W Q F I V G N A A V T F G T A I A A F Y L P V I I M T V L Y W H I S R A S K S R I K K D K K E K P P P S R E K K V T R T I L A I L L A F I I T W A P Y N V M V L I N T F C P N T V W T I G Y W L C Y I N S T I N P A C Y A L C N A T F K H F K K T L L M
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Residue Table


GPCRdb(A)
GPCRdb(A)
M2 receptor
TM2
2x60 2.61x60 Y80
2x63 2.64x63 Y83
TM3
3x33 3.33x33 Y104
ECL2
45x51 45.51x51 Y177
TM5
5x461 5.46x461 A194
TM6
6x48 6.48x48 W400
6x51 6.51x51 Y403
6x52 6.52x52 N404
TM7
7x31 7.32x31 N419
7x34 7.35x34 W422
7x38 7.39x38 Y426
7x41 7.42x41 C429
7x42 7.43x42 Y430