Structure information

M2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6OIK

SPECIES

Homo sapiens

RESOLUTION

3.600

PREFERRED CHAIN

R

REFERENCE

10.1126/SCIENCE.AAW5188

PUBLICATION DATE

May 8, 2019

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
LY2119620 Y80 2.61x60 TM2 polar (hydrogen bond)
LY2119620 Y80 2.61x60 TM2 Van der Waals
LY2119620 Y83 2.64x63 TM2 hydrophobic
LY2119620 Y83 2.64x63 TM2 Van der Waals
LY2119620 T84 2.65x64 TM2 Van der Waals
LY2119620 Y177 45.51x51 ECL2 hydrophobic
LY2119620 Y177 45.51x51 ECL2 Van der Waals
LY2119620 F181 ECL2 Van der Waals
LY2119620 N419 7.32x31 TM7 polar (hydrogen bond)
LY2119620 W422 7.35x34 TM7 Van der Waals
LY2119620 W422 7.35x34 TM7 aromatic (face-to-face)

Ligands

LY2119620

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Residue Diagrams

I N G I I T V L S L S G A V L V I F V V 1 F S L A C A D L I I G F V S M N L Y T L Y 2 I L L N M V S A N S V V Y D L A L W L D 3 A G M M I A A A W V L S F I L W A P A I 4 Y L V T M I I V P L Y F A A I A T G F T V 5 L A I L L A F I I T W A P Y N V M V L I 6 A P N I T S N I Y C L W Y G I T W V T 7
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ICL1 R H L Q ICL1ECL1 Y W P L ECL1ICL2 P L T Y P V K R ICL2ECL2 V R T V E D G E C Y I Q F F S ECL2ICL3 P V A N Q D P V S P S L V Q G R I V K P N N N N M P S S D D G L E H N K I Q N G K A P R D P V T E N C V Q G E E K E S S N D S T S V S A V A S N M R D D E I T Q D E N T V S T S L G H S K D E N S K Q T C I R I G T K T P K S D S C T P T N T T V E V V G S S G Q N G D E K Q N I V A R K I V K M T K Q P A K K ICL3ECL3 A P C I ECL3N-term M N N S T N S S N N S L A L T S P Y N-termC-term C H Y K N I G A T R C-term K T F E V V F I V L V A G S L S L V T I I G N I L V M V S I K V N T V N N Y F L F S L A C A D L I I G V F S M N L Y T L Y T V I G G P V V C D L W L A L D Y V V S N A S V M N L L I I S F D R Y F C V T K T T K M A G M M I A A A W V L S F I L W A P A I L F W Q F I V G N A A V T F G T A I A A F Y L P V I I M T V L Y W H I S R A S K S R I K K D K K E K P P P S R E K K V T R T I L A I L L A F I I T W A P Y N V M V L I N T F C P N T V W T I G Y W L C Y I N S T I N P A C Y A L C N A T F K H F K K T L L M
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Residue Table


GPCRdb(A)
GPCRdb(A)
M2 receptor
TM2
2x60 2.61x60 Y80
2x63 2.64x63 Y83
2x64 2.65x64 T84
ECL2
45x51 45.51x51 Y177
TM7
7x31 7.32x31 N419
7x34 7.35x34 W422