PDB
6OMM
Resolution
3.2 Å
Released
Feb. 26, 2020
Receptor
FPR2/ALX
Class
A
Species
Homo sapiens
Ligand
Function
WKYMVM
Agonist
Reference
10.1038/S41467-020-14728-9

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Ligand Amino Acid Generic Number Segment Interaction Type
WKYMVM E89 ECL1 polar (charge-charge)
WKYMVM H102 3.29x29 TM3 Van der Waals
WKYMVM V105 3.32x32 TM3 Van der Waals
WKYMVM D106 3.33x33 TM3 polar (hydrogen bond)
WKYMVM L109 3.36x36 TM3 hydrophobic
WKYMVM F110 3.37x37 TM3 hydrophobic
WKYMVM V113 3.40x40 TM3 Van der Waals
WKYMVM L164 4.64x65 TM4 hydrophobic
WKYMVM T177 45.51x51 ECL2 Van der Waals
WKYMVM F178 45.52x52 ECL2 hydrophobic
WKYMVM L198 5.35x36 TM5 hydrophobic
WKYMVM R201 5.38x39 TM5 polar (hydrogen bond)
WKYMVM R205 5.42x43 TM5 polar (hydrogen bond)
WKYMVM G209 5.46x461 TM5 Van der Waals
WKYMVM W254 6.48x48 TM6 hydrophobic
WKYMVM F257 6.51x51 TM6 Van der Waals
WKYMVM A261 6.55x55 TM6 hydrophobic
WKYMVM L268 ECL3 Van der Waals
WKYMVM M271 ECL3 Van der Waals
WKYMVM L272 ECL3 Van der Waals
WKYMVM D281 7.32x31 TM7 polar (charge-charge)
WKYMVM D281 7.32x31 TM7 polar (hydrogen bond)
WKYMVM V284 7.35x34 TM7 hydrophobic
WKYMVM N285 7.36x35 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 T R ICL1ECL1 E K W P F ECL1ICL2 P V W A Q N H R ICL2ECL2 T T V T I P N G D T Y C T F N F A S W G G ECL2ICL3 M I K S ICL3ECL3 L K E M L F Y G K ECL3N-term M E T N F S T P L N E Y E E V S Y E N-termC-term P T S L E R A L S E D S A P T N D T A A N S A S P P A E T E L Q A M C-term S A G Y T V L R I L P L V V L G V T F V L G V L G N G L V I W V A G F R M T V T T I C Y L N L A L A D F S F T A T L P F L I V S M A M G G W F L C K L I H I V V D I N L F G S V F L I G F I A L D R C I C V L H T V S L A M K V I V G P W I L A L V L T L P V F L F L T P E E R L K V A I T M L T A R G I I R F V I G F S L P M S I V A I C Y G L I A A K I H K K G S R P L R V L T A V V A S F F I C W F P F Q L V A L L G T V W Y K I I D I L V N P T S S L A F F N S C L N P M L Y V F V G Q D L I H F R E R S L
Helix box plot — Download: PNG | SVG G N G L V G L V F T V G L V V L P L I R 1 L N L A L A D F S F T A T L P F L I V S 2 F G I L F V S G F L N I D V V I H I L K 3 A M K V I V G P W I L A L V L T L P V 4 Y C I A V I S M P L S F G I V F R I I G R 5 T A V V A S F F I C W F P F Q L V A L L 6 M P N L C S N F F A L S S T P N V L I 7

GPCRdb(A)
GPCRdb(A)
FPR2/ALX
TM3
3x29 3.29x29 H102
3x32 3.32x32 V105
3x33 3.33x33 D106
3x36 3.36x36 L109
3x37 3.37x37 F110
3x40 3.40x40 V113
TM4
4x65 4.64x65 L164
ECL2
45x51 45.51x51 T177
45x52 45.52x52 F178
TM5
5x36 5.35x36 L198
5x39 5.38x39 R201
5x43 5.42x43 R205
5x461 5.46x461 G209
TM6
6x48 6.48x48 W254
6x51 6.51x51 F257
6x55 6.55x55 A261
TM7
7x31 7.32x31 D281
7x34 7.35x34 V284
7x35 7.36x35 N285