Structure information

GLP-1 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

6ORV

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

E

REFERENCE

10.1038/s41586-019-1902-z

PUBLICATION DATE

Jan. 8, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL3950796 Y145 1.40x40 TM1 hydrophobic
CHEMBL3950796 Y148 1.43x43 TM1 aromatic (edge-to-face)
CHEMBL3950796 V194 2.64x64 TM2 hydrophobic
CHEMBL3950796 K197 2.67x67 TM2 polar (charge-assisted hydrogen bond)
CHEMBL3950796 D198 2.68x68 TM2 Van der Waals
CHEMBL3950796 A200 2.70x70 TM2 Van der Waals
CHEMBL3950796 A200 2.70x70 TM2 hydrophobic
CHEMBL3950796 L201 2.71x71 TM2 hydrophobic
CHEMBL3950796 L201 2.71x71 TM2 Van der Waals
CHEMBL3950796 W203 2.73x73 TM2 hydrophobic
CHEMBL3950796 W203 2.73x73 TM2 Van der Waals
CHEMBL3950796 M204 2.74x74 TM2 Van der Waals
CHEMBL3950796 M204 2.74x74 TM2 hydrophobic
CHEMBL3950796 L217 ECL1 hydrophobic
CHEMBL3950796 L217 ECL1 Van der Waals
CHEMBL3950796 Y220 ECL1 polar (hydrogen bond)
CHEMBL3950796 Y220 ECL1 Van der Waals
CHEMBL3950796 F230 3.33x33 TM3 hydrophobic
CHEMBL3950796 F230 3.33x33 TM3 Van der Waals
CHEMBL3950796 W297 45.51x51 ECL2 aromatic (edge-to-face)
CHEMBL3950796 W297 45.51x51 ECL2 Van der Waals

Ligands

CHEMBL3950796

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Residue Diagrams

V L A S F S L A Y G V T Y I I Y L F L L 1 L N L F A S F I L R A L S V F I K D A A 2 V L L W Y Y N A A V C Y Q M L L F V L R 3 I F R L Y V S G I W G V P L L F V V P W G 4 F I L F N V G I A F L I P L R I I L W Y N 5 L T L I P L L G T H E V I F A F V M 6 I A V M L G Q F S T F S L E T F L K I 7
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ICL1 R H L H ICL1ECL1 T A A Q Q H Q W D G L L S Y Q D S ECL1ICL2 S V L ICL2ECL2 D E G C W T R N S ECL2ICL3 M ICL3ECL3 D E H A R ECL3N-term M A G A P G P L R L A L L L L G M V G R A G P R P Q G A T V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E S K R G E R S S P N-termC-term S M K P L K C P T S S L S S G A T A G S S M Y T A T C Q A S C S C-term E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A N L C K T D I K C R L A K S T L T L I P L L G T H E V I F A F V M G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E F R K W R L I Q R V Q L E S W E R E H L H D S
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Residue Table


GPCRdb(A)
GPCRdb(B)
GLP-1 receptor
TM1
1x36 1.40x40 Y145
1x39 1.43x43 Y148
TM2
2x57 2.64x64 V194
2x60 2.67x67 K197
2x61 2.68x68 D198
2x63 2.70x70 A200
2x64 2.71x71 L201
2x66 2.73x73 W203
2x67 2.74x74 M204
TM3
3x29 3.33x33 F230
ECL2
45x51 45.51x51 W297