Structure information

AT1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6OS0

SPECIES

Homo sapiens

RESOLUTION

2.900

PREFERRED CHAIN

A

PUBLICATION DATE

Feb. 19, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Angiotensinogen Q15 N-term polar (hydrogen bond with backbone)
Angiotensinogen D17 N-term polar (hydrogen bond with backbone)
Angiotensinogen D17 N-term polar (charge-assisted hydrogen bond)
Angiotensinogen D17 N-term polar (charge-charge)
Angiotensinogen W84 2.60x60 TM2 hydrophobic
Angiotensinogen Y92 ECL1 hydrophobic
Angiotensinogen L112 3.36x36 TM3 hydrophobic
Angiotensinogen R167 ECL2 polar (charge-assisted hydrogen bond)
Angiotensinogen A181 45.51x51 ECL2 hydrophobic
Angiotensinogen F182 45.52x52 ECL2 polar (hydrogen bond with backbone)
Angiotensinogen F182 45.52x52 ECL2 polar (hydrogen bond with backbone)
Angiotensinogen Y184 ECL2 polar (hydrogen bond with backbone)
Angiotensinogen Y184 ECL2 polar (hydrogen bond with backbone)
Angiotensinogen K199 5.42x43 TM5 polar (charge-charge)
Angiotensinogen D1263 6.58x58 TM6 polar (charge-assisted hydrogen bond)
Angiotensinogen D1263 6.58x58 TM6 polar (charge-assisted hydrogen bond)
Angiotensinogen D1281 7.32x31 TM7 polar (charge-assisted hydrogen bond)
Angiotensinogen D1281 7.32x31 TM7 polar (charge-assisted hydrogen bond)
Angiotensinogen M1284 7.35x34 TM7 hydrophobic
Angiotensinogen I1288 7.39x38 TM7 hydrophobic

Ligands

Angiotensinogen

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Residue Diagrams

S N G F I G V V F I I S Y L T P I M V F 1 L N L A L A D L C F L L T L P L W A V Y 2 C T L L F V S A Y L N F S V S A S A I K 3 A K V T C I I I W L L A G L A S L P A 4 Y S T L I I L F P F L F G L I N K T L G L 5 M A I V L F F F F S W I P H Q I F T F L 6 L P N L C N N F Y A I C I T I P M A T 7
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ICL1 M K L K ICL1ECL1 Y R W P F ECL1ICL2 P M K S R L R R ICL2ECL2 N V F F I E N T N I T V C A F H Y E S Q N S T ECL2ICL3 Y E I Q K N K ICL3ECL3 I I R ECL3N-term M I L N S S T E D G I K R I Q D D C P K A G R N-termC-term P P K A K S H S N L S T K M S T L S Y R P S D N V S S S T K K P A P C F E V E C-term H N Y I F V M I P T L Y S I I F V V G I F G N S L V V I V I Y F Y T V A S V F L L N L A L A D L C F L L T L P L W A V Y T A M E G N Y L C K I A S A S V S F N L Y A S V F L L T C L S I D R Y L A I V H T M L V A K V T C I I I W L L A G L A S L P A I I H R L P I G L G L T K N I L G F L F P F L I I L T S Y T L I W K A L K K A P R N D D I F K I I M A I V L F F F F S W I P H Q I F T F L D V L I Q L G D C R I A D I V D T A M P I T I C I A Y F N N C L N P L F Y G F L G K K F L Q I F K R Y L L K Y
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Residue Table


GPCRdb(A)
GPCRdb(A)
AT1 receptor
TM2
2x60 2.60x60 W84
TM3
3x36 3.36x36 L112
ECL2
45x51 45.51x51 A181
45x52 45.52x52 F182
TM5
5x43 5.42x43 K199
TM6
6x58 6.58x58 D263
TM7
7x31 7.32x31 D281
7x34 7.35x34 M284
7x38 7.39x38 I288