Structure information

CRF1 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

6P9X

SPECIES

Homo sapiens

RESOLUTION

2.910

PREFERRED CHAIN

R

REFERENCE

10.1016/J.MOLCEL.2020.01.012

PUBLICATION DATE

Feb. 5, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Corticoliberin Y116 1.36x36 TM1 hydrophobic
Corticoliberin V172 2.67x67 TM2 hydrophobic
Corticoliberin Y195 3.36x36 TM3 polar (hydrogen bond)
Corticoliberin F260 45.52x52 ECL2 polar (hydrogen bond with backbone)
Corticoliberin Q273 5.40x40 TM5 polar (charge-assisted hydrogen bond)
Corticoliberin M276 5.43x43 TM5 hydrophobic
Corticoliberin Y327 6.53x53 TM6 polar (hydrogen bond with backbone)
Corticoliberin F331 ECL3 polar (hydrogen bond with backbone)
Corticoliberin V332 ECL3 hydrophobic
Corticoliberin F344 7.38x37 TM7 hydrophobic
Corticoliberin I345 7.39x38 TM7 hydrophobic
Corticoliberin E352 7.46x45 TM7 polar (charge-assisted hydrogen bond)

Ligands

Corticoliberin

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Residue Diagrams

L L A V L S I C H G L Y N I I V A V H Y 1 W N L I S A F I L R N A T W F V V Q L T 2 G F M W F F N T V H F Y N Y A A T V L R 3 R K W M F I C G I W G V P F P I I V A W A 4 L F I F N I L L V L I M P G Q Y I Y D T 5 L V L L P L L G I T Y M L F F V 6 V S V F F G Q F S E L F S N F Y I F V 7
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ICL1 R S I R ICL1ECL1 M S P E V H Q S N ECL1ICL2 T Y S T D R ICL2ECL2 N E K C W F G K R P G V Y ECL2ICL3 R A S T T ICL3ECL3 N P G E D ECL3N-term M G G H P Q L R L V K A L L L L G L N P V S A S L Q D Q H C E S L S L A S N I S G L Q C N A S V D L I G T C W P R S P A G Q L V V R P C P A F F Y G V R Y N T T N N G Y R E C L A N G S W A A R V N Y S E C N-termC-term R A M S I P T S P T R V S F H S I K Q S T A V C-term Q E I L N E E K K S K V H Y H V A V I I N Y L G H C I S L V A L L V A F V L F L R L C L R N I I H W N L I S A F I L R N A T W F V V Q L T V G W C R L V T A A Y N Y F H V T N F F W M F G E G C Y L H T A I V L L R K W M F I C I G W G V P F P I I V A W A I G K L Y Y D T D Y I Y Q G P M I L V L L I N F I F L F N I V R I L M T K L S E T I Q Y R K A V K A T L V L L P L L G I T Y M L F F V E V S R V V F I Y F N S F L E S F Q G F F V S V F Y C F L N S E I R K W Q D R A R V R S A R W H R K H S I V A
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Residue Table


GPCRdb(A)
GPCRdb(B)
CRF1 receptor
TM1
1x32 1.36x36 Y116
TM2
2x60 2.67x67 V172
TM3
3x32 3.36x36 Y195
ECL2
45x52 45.52x52 F260
TM5
5x44 5.40x40 Q273
5x47 5.43x43 M276
TM6
6x48 6.53x53 Y327
TM7
7x33 7.38x37 F344
7x34 7.39x38 I345
7x41 7.46x45 E352