Structure information

CRF1 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

6P9X

SPECIES

Homo sapiens

RESOLUTION

2.910

PREFERRED CHAIN

R

REFERENCE

10.1016/J.MOLCEL.2020.01.012

PUBLICATION DATE

Feb. 5, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Corticoliberin Y116 1.36x36 TM1 hydrophobic
Corticoliberin A119 1.39x39 TM1 hydrophobic
Corticoliberin V172 2.67x67 TM2 hydrophobic
Corticoliberin P178 ECL1 hydrophobic
Corticoliberin Y195 3.36x36 TM3 Van der Waals
Corticoliberin Y195 3.36x36 TM3 polar (hydrogen bond)
Corticoliberin N196 3.37x37 TM3 Van der Waals
Corticoliberin H199 3.40x40 TM3 Van der Waals
Corticoliberin F203 3.44x44 TM3 Van der Waals
Corticoliberin F260 45.52x52 ECL2 polar (hydrogen bond with backbone)
Corticoliberin F260 45.52x52 ECL2 Van der Waals
Corticoliberin K262 ECL2 Van der Waals
Corticoliberin Y267 ECL2 Van der Waals
Corticoliberin Y272 5.39x39 TM5 Van der Waals
Corticoliberin Q273 5.40x40 TM5 Van der Waals
Corticoliberin Q273 5.40x40 TM5 polar (hydrogen bond)
Corticoliberin M276 5.43x43 TM5 Van der Waals
Corticoliberin M276 5.43x43 TM5 hydrophobic
Corticoliberin I277 5.44x44 TM5 Van der Waals
Corticoliberin Y327 6.53x53 TM6 polar (hydrogen bond with backbone)
Corticoliberin Y327 6.53x53 TM6 Van der Waals
Corticoliberin F331 ECL3 polar (hydrogen bond with backbone)
Corticoliberin F331 ECL3 Van der Waals
Corticoliberin V332 ECL3 Van der Waals
Corticoliberin V332 ECL3 hydrophobic
Corticoliberin F344 7.38x37 TM7 hydrophobic
Corticoliberin F344 7.38x37 TM7 Van der Waals
Corticoliberin I345 7.39x38 TM7 hydrophobic
Corticoliberin I345 7.39x38 TM7 Van der Waals
Corticoliberin N348 7.42x41 TM7 Van der Waals
Corticoliberin S349 7.43x42 TM7 Van der Waals
Corticoliberin E352 7.46x45 TM7 polar (charge-assisted hydrogen bond)

Ligands

Corticoliberin

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Residue Diagrams

L L A V L S I C H G L Y N I I V A V H Y 1 W N L I S A F I L R N A T W F V V Q L T 2 G F M W F F N T V H F Y N Y A A T V L R 3 R K W M F I C G I W G V P F P I I V A W A 4 L F I F N I L L V L I M P G Q Y I Y D T 5 L V L L P L L G I T Y M L F F V 6 V S V F F G Q F S E L F S N F Y I F V 7
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ICL1 R S I R ICL1ECL1 M S P E V H Q S N ECL1ICL2 T Y S T D R ICL2ECL2 N E K C W F G K R P G V Y ECL2ICL3 R A S T T ICL3ECL3 N P G E D ECL3N-term M G G H P Q L R L V K A L L L L G L N P V S A S L Q D Q H C E S L S L A S N I S G L Q C N A S V D L I G T C W P R S P A G Q L V V R P C P A F F Y G V R Y N T T N N G Y R E C L A N G S W A A R V N Y S E C N-termC-term R A M S I P T S P T R V S F H S I K Q S T A V C-term Q E I L N E E K K S K V H Y H V A V I I N Y L G H C I S L V A L L V A F V L F L R L C L R N I I H W N L I S A F I L R N A T W F V V Q L T V G W C R L V T A A Y N Y F H V T N F F W M F G E G C Y L H T A I V L L R K W M F I C I G W G V P F P I I V A W A I G K L Y Y D T D Y I Y Q G P M I L V L L I N F I F L F N I V R I L M T K L S E T I Q Y R K A V K A T L V L L P L L G I T Y M L F F V E V S R V V F I Y F N S F L E S F Q G F F V S V F Y C F L N S E I R K W Q D R A R V R S A R W H R K H S I V A
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Residue Table


GPCRdb(A)
GPCRdb(B)
CRF1 receptor
TM1
1x32 1.36x36 Y116
1x35 1.39x39 A119
TM2
2x60 2.67x67 V172
TM3
3x32 3.36x36 Y195
3x33 3.37x37 N196
3x36 3.40x40 H199
3x40 3.44x44 F203
ECL2
45x52 45.52x52 F260
TM5
5x43 5.39x39 Y272
5x44 5.40x40 Q273
5x47 5.43x43 M276
5x48 5.44x44 I277
TM6
6x48 6.53x53 Y327
TM7
7x33 7.38x37 F344
7x34 7.39x38 I345
7x37 7.42x41 N348
7x38 7.43x42 S349
7x41 7.46x45 E352