Structure information

CRF1 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

6PB0

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

R

PUBLICATION DATE

Feb. 12, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Urocortin E109 N-term polar (charge-assisted hydrogen bond)
Urocortin K113 1.33x33 TM1 polar (charge-assisted hydrogen bond)
Urocortin V120 1.40x40 TM1 hydrophobic
Urocortin W169 2.64x64 TM2 polar (hydrogen bond)
Urocortin Y195 3.36x36 TM3 polar (hydrogen bond)
Urocortin F260 45.52x52 ECL2 polar (hydrogen bond with backbone)
Urocortin Y272 5.39x39 TM5 polar (charge-assisted hydrogen bond)
Urocortin M276 5.43x43 TM5 hydrophobic
Urocortin Y327 6.53x53 TM6 hydrophobic
Urocortin F330 ECL3 polar (hydrogen bond with backbone)
Urocortin F331 ECL3 polar (hydrogen bond with backbone)
Urocortin F331 ECL3 polar (hydrogen bond with backbone)
Urocortin F344 7.38x37 TM7 hydrophobic
Urocortin I345 7.39x38 TM7 hydrophobic
Urocortin N348 7.42x41 TM7 polar (hydrogen bond)
Urocortin N348 7.42x41 TM7 polar (hydrogen bond)
Urocortin E352 7.46x45 TM7 polar (charge-assisted hydrogen bond)

Ligands

Urocortin

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Residue Diagrams

L L A V L S I C H G L Y N I I V A V H Y 1 W N L I S A F I L R N A T W F V V Q L T 2 G F M W F F N T V H F Y N Y A A T V L R 3 R K W M F I C G I W G V P F P I I V A W A 4 L F I F N I L L V L I M P G Q Y I Y D T 5 L V L L P L L G I T Y M L F F V 6 V S V F F G Q F S E L F S N F Y I F V 7
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ICL1 R S I R ICL1ECL1 M S P E V H Q S N ECL1ICL2 T Y S T D R ICL2ECL2 N E K C W F G K R P G V Y ECL2ICL3 R A S T T ICL3ECL3 N P G E D ECL3N-term M G G H P Q L R L V K A L L L L G L N P V S A S L Q D Q H C E S L S L A S N I S G L Q C N A S V D L I G T C W P R S P A G Q L V V R P C P A F F Y G V R Y N T T N N G Y R E C L A N G S W A A R V N Y S E C N-termC-term R A M S I P T S P T R V S F H S I K Q S T A V C-term Q E I L N E E K K S K V H Y H V A V I I N Y L G H C I S L V A L L V A F V L F L R L C L R N I I H W N L I S A F I L R N A T W F V V Q L T V G W C R L V T A A Y N Y F H V T N F F W M F G E G C Y L H T A I V L L R K W M F I C I G W G V P F P I I V A W A I G K L Y Y D T D Y I Y Q G P M I L V L L I N F I F L F N I V R I L M T K L S E T I Q Y R K A V K A T L V L L P L L G I T Y M L F F V E V S R V V F I Y F N S F L E S F Q G F F V S V F Y C F L N S E I R K W Q D R A R V R S A R W H R K H S I V A
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Residue Table


GPCRdb(A)
GPCRdb(B)
CRF1 receptor
TM1
1x29 1.33x33 K113
1x36 1.40x40 V120
TM2
2x57 2.64x64 W169
TM3
3x32 3.36x36 Y195
ECL2
45x52 45.52x52 F260
TM5
5x43 5.39x39 Y272
5x47 5.43x43 M276
TM6
6x48 6.53x53 Y327
TM7
7x33 7.38x37 F344
7x34 7.39x38 I345
7x37 7.42x41 N348
7x41 7.46x45 E352