Structure information

CRF2 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

6PB1

SPECIES

Homo sapiens

RESOLUTION

2.800

PREFERRED CHAIN

P

PUBLICATION DATE

Feb. 12, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Urocortin Q106 N-term polar (hydrogen bond)
Urocortin Q106 N-term polar (hydrogen bond)
Urocortin R107 N-term polar (charge-charge)
Urocortin Y113 1.36x36 TM1 hydrophobic
Urocortin W166 2.64x64 TM2 polar (hydrogen bond)
Urocortin L169 2.67x67 TM2 hydrophobic
Urocortin E178 ECL1 polar (charge-assisted hydrogen bond)
Urocortin F191 3.36x36 TM3 hydrophobic
Urocortin F256 45.52x52 ECL2 polar (hydrogen bond with backbone)
Urocortin Q269 5.40x40 TM5 polar (charge-assisted hydrogen bond)
Urocortin F327 ECL3 hydrophobic
Urocortin F340 7.38x37 TM7 hydrophobic
Urocortin I341 7.39x38 TM7 hydrophobic
Urocortin N344 7.42x41 TM7 polar (hydrogen bond)

Ligands

Urocortin

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Residue Diagrams

V L A A V S V C H G L Y N V V L A I R Y 1 W N L I T T F I L R N V M W F L L Q L V 2 V F M W F F N T V V F Y N F I T T I C R 3 R K C L F L F G I W C I P F P I I V A W A 4 L F V F N I L L V L I I P G Q Y I Y D V 5 L V L L P L L G I T Y M L F F V 6 V S V F F G Q F S Q L F S N F Y I F M 7
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ICL1 R S I R ICL1ECL1 D H E V H E S N ECL1ICL2 T Y S T E R L ICL2ECL2 N E Q C W F G K E P G D L ECL2ICL3 S T T ICL3ECL3 N P G E D ECL3N-term M D A A L L H S L L E A N C S L A L A E E L L L D G W G P P L D P E G P Y S Y C N T T L D Q I G T C W P R S A A G A L V E R P C P E Y F N G V K Y N T T R N A Y R E C L E N G T W A S K I N Y S Q C E N-termC-term R A M S I P T S P T R I S F H S I K Q T A A V C-term P I L D D K Q R K Y D L H Y R I A L V V N Y L G H C V S V A A L V A A F L L F L A L C L R N V I H W N L I T T F I L R N V M W F L L Q L V E V W C R C I T T I F N Y F V V T N F F W M F V E G C Y L H T A I V M R K C L F L F I G W C I P F P I I V A W A I G K L Y Y E V D Y I Y Q G P I I L V L L I N F V F L F N I V R I L M T K L R A S E T I Q Y R K A V K A T L V L L P L L G I T Y M L F F V D L S Q I M F I Y F N S F L Q S F Q G F F V S V F Y C F F N G E V R K W Q D R V P V R S A R W H R H H S L M A
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Residue Table


GPCRdb(A)
GPCRdb(B)
CRF2 receptor
TM1
1x32 1.36x36 Y113
TM2
2x57 2.64x64 W166
2x60 2.67x67 L169
TM3
3x32 3.36x36 F191
ECL2
45x52 45.52x52 F256
TM5
5x44 5.40x40 Q269
TM7
7x33 7.38x37 F340
7x34 7.39x38 I341
7x37 7.42x41 N344