Structure information

β2-adrenoceptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6PS0

SPECIES

Homo sapiens

RESOLUTION

3.400

PREFERRED CHAIN

A

PUBLICATION DATE

Nov. 13, 2019

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Carazolol D113 3.32x32 TM3 polar (charge-assisted hydrogen bond)
Carazolol D113 3.32x32 TM3 polar (charge-charge)
Carazolol V114 3.33x33 TM3 hydrophobic
Carazolol V117 3.36x36 TM3 hydrophobic
Carazolol F193 45.52x52 ECL2 hydrophobic
Carazolol S203 5.42x43 TM5 polar (hydrogen bond)
Carazolol F289 6.51x51 TM6 hydrophobic
Carazolol F290 6.52x52 TM6 aromatic (edge-to-face)
Carazolol N312 7.39x38 TM7 polar (charge-assisted hydrogen bond)
Carazolol N312 7.39x38 TM7 polar (hydrogen bond)

Ligands

Carazolol

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Residue Diagrams

V N G F V I A L V I L S M V I G M G V V 1 T S L A C A D L V M G A L V V P F G A A H 2 V C L T E I S A T V C L V D I S T W F E 3 A R V I I L M V W I V S G L T S F L P I 4 Y V F V M I V L P V Y F S V I S S A I A Y 5 G I I M G T F T L C W L P F F I V N I V 6 L P N F G S N V Y G I W N L L I Y V E 7
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ICL1 E R L Q ICL1ECL1 M W T F ECL1ICL2 P F K Y Q S L L ICL2ECL2 W Y R A T H Q E A I N C Y A N E T C C D F F T ECL2ICL3 G R F H V Q N L S Q V E Q D G R T G H G L R R S ICL3ECL3 D N L I ECL3N-term M G Q P G N G S A F L L A P N G S H A P D H D V T N-termC-term L R R S S L K A Y G N G Y S S N G N T G E Q S G Y H V E Q E K E N K L L C E D L P G T E D F V G H Q G T V P S D N I D S Q G R N C S T N D S L L C-term Q E R D E V W V V G M G I V M S L I V L A I V F G N V L V I T A I A K F T V T N Y F I T S L A C A D L V M G L A V V P F G A A H I L M K G N F W C E F W T S I D V L C V T A S I E T L C V I A V D R Y F A I T S T K N K A R V I I L M V W I V S G L T S F L P I Q M H N Q A Y A I A S S I V S F Y V P L V I M V F V Y S R V F Q E A K R Q L Q K I D K S E S K F C L K E H K A L K T L G I I M G T F T L C W L P F F I V N I V H V I Q R K E V Y I L L N W I G Y V N S G F N P L I Y C R S P D F Q E F R I A L L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
β2-adrenoceptor
TM3
3x32 3.32x32 D113
3x33 3.33x33 V114
3x36 3.36x36 V117
ECL2
45x52 45.52x52 F193
TM5
5x43 5.42x43 S203
TM6
6x51 6.51x51 F289
6x52 6.52x52 F290
TM7
7x38 7.39x38 N312