Structure information

MT1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6PS8

SPECIES

Homo sapiens

RESOLUTION

3.300

PREFERRED CHAIN

A

PUBLICATION DATE

Nov. 13, 2019

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
2-phenylmelatonin V111 3.36x36 TM3 hydrophobic
2-phenylmelatonin V159 4.57x57 TM4 hydrophobic
2-phenylmelatonin N162 4.60x61 TM4 polar (hydrogen bond)
2-phenylmelatonin F179 45.52x52 ECL2 hydrophobic
2-phenylmelatonin Q181 ECL2 polar (hydrogen bond)
2-phenylmelatonin L254 6.51x51 TM6 hydrophobic
2-phenylmelatonin Y281 7.39x38 TM7 hydrophobic
2-phenylmelatonin A284 7.42x41 TM7 hydrophobic
2-phenylmelatonin Y285 7.43x42 TM7 hydrophobic

Ligands

2-phenylmelatonin

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Residue Diagrams

L N G L I D V V I T F I L V C A L A S A 1 V S L A V A D L V V A Y I P Y P L V L M S 2 G T I N F I S G I V S L G M L F G S V Q 3 S L C Y V L L I W L L T L A A V L P N 4 Y C F I V I I M P V L F H F V V V A I T Y 5 F V V F V L F A I C W A P L N F I G L A 6 I A N L C S N F Y A M Y Y S A V F L W 7
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ICL1 K K L R ICL1ECL1 G W N L ECL1ICL2 S L K Y D K L Y ICL2ECL2 T L Q Y D P R I Y S C T F A Q S V ECL2ICL3 K P D R K ICL3ECL3 P A S M V P R I ECL3N-term M Q G N G S A L P N A S Q P V L R G D G A R N-termC-term A R V F F V D S S N D V A D R V K W K P S P L M T N N N V V K V D S V C-term P S W L A S A L A C V L I F T I V V D I L G N L L V I L S V Y R N N A G N I F V V S L A V A D L V V A I Y P Y P L V L M S I F N N G Y L H C Q V S G F L M G L S V I G S I F N I T G I A I N R Y C Y I C H S S K N S L C Y V L L I W L L T L A A V L P N L R A G S S A Y T I A V V V F H F L V P M I I V I F C Y L R I W I L V L Q V R Q R V P K L K P Q D F R N F V T M F V V F V L F A I C W A P L N F I G L A V A S D P E W L F V A S Y Y M A Y F N S C L N A I I Y G L L N Q N Y R R L C T F R K E I I V S
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Residue Table


GPCRdb(A)
GPCRdb(A)
MT1 receptor
TM3
3x36 3.36x36 V111
TM4
4x57 4.57x57 V159
4x61 4.60x61 N162
ECL2
45x52 45.52x52 F179
TM6
6x51 6.51x51 L254
TM7
7x38 7.39x38 Y281
7x41 7.42x41 A284
7x42 7.43x42 Y285