PDB
6PT0
Resolution
3.2 Å
Released
Feb. 12, 2020
Receptor
CB2
Class
A
Species
Homo sapiens
Ligand
Function
WIN55212-2
Agonist
Reference
10.1016/J.CELL.2020.01.007

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Ligand Amino Acid Generic Number Segment Interaction Type
WIN55212-2 F87 2.57x57 TM2 hydrophobic
WIN55212-2 S90 2.60x60 TM2 Van der Waals
WIN55212-2 F91 2.61x61 TM2 aromatic (edge-to-face)
WIN55212-2 F94 2.64x64 TM2 hydrophobic
WIN55212-2 F94 2.64x64 TM2 aromatic (edge-to-face)
WIN55212-2 I110 3.29x29 TM3 hydrophobic
WIN55212-2 T114 3.33x33 TM3 Van der Waals
WIN55212-2 F183 ECL2 hydrophobic
WIN55212-2 P184 ECL2 hydrophobic
WIN55212-2 I186 ECL2 Van der Waals
WIN55212-2 Y190 5.39x39 TM5 Van der Waals
WIN55212-2 L191 5.40x40 TM5 Van der Waals
WIN55212-2 W194 5.43x43 TM5 Van der Waals
WIN55212-2 V261 6.51x51 TM6 hydrophobic
WIN55212-2 F281 7.35x34 TM7 Van der Waals
WIN55212-2 S285 7.39x38 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 H Q L R R ICL1ECL1 F H G V D ECL1ICL2 P P S Y K A L L ICL2ECL2 W T C C P R P C S E L F P L I ECL2ICL3 H Q D R Q V P G M A R M ICL3ECL3 T L ECL3N-term M E E C W V T E I A N G S K D G L D S N P M K D Y M I L N-termC-term C V R G L G S E A K E E A P R S S V T E T E A D G K I T P W P D S R D L D L S D C C-term S G P Q K T A V A V L C T L L G L L S A L E N V A V L Y L I L S S K P S Y L F I G S L A G A D F L A S V V F A C S F V N F H V S K A V F L L K I G S V T M T F T A S V G S L L L T A I D R Y L C L R Y T R G R A L V T L G I M W V L S A L V S Y L P L M G P N D Y L L S W L L F I A F L F S G I I Y T Y G H V L W K A H Q H V A S L S G R L D V R L A K T L G L V L A V L L I C W F P V L A L M A H S L A T S D Q V K K A F A F C S M L C L I N S M V N P V I Y A L R S G E A H H W K K I R S S C L A H
Helix box plot — Download: PNG | SVG V N E L A S L L G L L T C L V A V A T K 1 G S L A G A D F L A S V V F A C S F V N 2 L L L S G V S A T F T M T V S G I K L L 3 A L V T L G I M W V L S A L V S Y L P L 4 Y T Y I I G S F L F A I F L L W S L L Y 5 G L V L A V L L I C W F P V L A L M A H 6 V P N V M S N I L C L M S C F A F A K 7

GPCRdb(A)
GPCRdb(A)
CB2 receptor
TM2
2x57 2.57x57 F87
2x60 2.60x60 S90
2x61 2.61x61 F91
2x64 2.64x64 F94
TM3
3x29 3.29x29 I110
3x33 3.33x33 T114
TM5
5x39 5.39x39 Y190
5x40 5.40x40 L191
5x43 5.43x43 W194
TM6
6x51 6.51x51 V261
TM7
7x34 7.35x34 F281
7x38 7.39x38 S285