Structure information

CysLT2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6RZ8

SPECIES

Homo sapiens

RESOLUTION

2.700

PREFERRED CHAIN

A

PUBLICATION DATE

Dec. 11, 2019

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
ONO-2080365 K37 1.31x31 TM1 polar (charge-charge)
ONO-2080365 K37 1.31x31 TM1 polar (charge-charge)
ONO-2080365 Y119 3.33x33 TM3 polar (hydrogen bond)
ONO-2080365 Y119 3.33x33 TM3 polar (hydrogen bond)
ONO-2080365 Y119 3.33x33 TM3 polar (charge-assisted hydrogen bond)
ONO-2080365 Y119 3.33x33 TM3 polar (hydrogen bond)
ONO-2080365 Y123 3.37x37 TM3 aromatic (face-to-edge)
ONO-2080365 I166 4.53x53 TM4 hydrophobic
ONO-2080365 S169 4.56x56 TM4 polar (hydrogen bond)
ONO-2080365 L190 ECL2 hydrophobic
ONO-2080365 K194 5.31x32 TM5 polar (charge-charge)
ONO-2080365 L198 5.35x36 TM5 hydrophobic
ONO-2080365 M201 5.38x39 TM5 hydrophobic
ONO-2080365 R267 6.55x55 TM6 polar (charge-assisted hydrogen bond)
ONO-2080365 L271 6.59x59 TM6 hydrophobic
ONO-2080365 H284 7.32x31 TM7 polar (charge-assisted hydrogen bond)
ONO-2080365 L287 7.35x34 TM7 hydrophobic

Ligands

ONO-2080365

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Residue Diagrams

G N G L V G W F F I I L Y V I P F F E R 1 L N L A I S D L L F I S T L P F R A D Y 2 V T L F Y I S S Y M N V Y L S Y S M I R 3 A W I L C G I I W I L I M A S S I M L 4 Y C I S L T F F P L L C G V V L A I Y N M 5 I I I T L I I F L F C F L P Y H T L R T V 6 L P N F C A N A A A L A L T I V L A K 7
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ICL1 Y K K S ICL1ECL1 S N W I F ECL1ICL2 P F R L L H V T ICL2ECL2 G S E Q N G S V T S C L E L N L Y K ECL2ICL3 E V P E ICL3ECL3 K V G L C ECL3N-term M E R K F M S L Q P S I S V S E M E P N G T F S N N N S R N N-termC-term G H P Q K A K T K C V F P V S V W L R K E T R V C-term C T I E N F K R E F F P I V Y L I I F F W G V L G N G L S I Y V F L Q P T S V N V F M L N L A I S D L L F I S T L P F R A D Y Y L R G G D L A C R I M S Y S L Y V N M Y S S I Y F L T V L S V V R F L A M V H S I R S A W I L C G I I W I L I M A S S I M L L D S I A K L Q T M N Y I A L V V G C L L P F F T L S I C Y L L I I R V L L K V S G L R V S H R K A L T T I I I T L I I F F L C F L P Y H T L R T V H L T T W K D R L H K A L V I T L A L A A A N A C F N P L L Y Y F A G E N L K S F K D R A L R K
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Residue Table


GPCRdb(A)
GPCRdb(A)
CysLT2 receptor
TM1
1x31 1.31x31 K37
TM3
3x33 3.33x33 Y119
3x37 3.37x37 Y123
TM4
4x53 4.53x53 I166
4x56 4.56x56 S169
TM5
5x36 5.35x36 L198
5x39 5.38x39 M201
TM6
6x55 6.55x55 R267
6x59 6.59x59 L271
TM7
7x31 7.32x31 H284
7x34 7.35x34 L287