Structure information

OX1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6TOT

SPECIES

Homo sapiens

RESOLUTION

2.220

PREFERRED CHAIN

B

PUBLICATION DATE

Jan. 15, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Lemborexant S103 2.61x60 TM2 polar (hydrogen bond)
Lemborexant P123 3.29x29 TM3 polar (hydrogen bond with backbone)
Lemborexant Q126 3.32x32 TM3 polar (hydrogen bond)
Lemborexant F219 5.42x43 TM5 hydrophobic
Lemborexant I314 6.51x51 TM6 hydrophobic
Lemborexant H344 7.39x38 TM7 aromatic (face-to-face)
Lemborexant H344 7.39x38 TM7 polar (hydrogen bond)

Ligands

Lemborexant

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Residue Diagrams

T N G V L A V V F V A V Y A A I L V W E 1 V N L S L A D V L V T I A C L P A S L L V 2 F S L T L V A V S V S V A Q L Y P I V K 3 A R G S I L G I W A V S L A I M V P Q 4 Y A M A M L G L P A L Y T V I F F C S H Y 5 M V V L L V F A L C Y L P I S V L N V L 6 I P N A A S N A Y V L W H S F T F C A 7
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ICL1 H H M R ICL1ECL1 S W L F ECL1ICL2 P L L F K S ICL2ECL2 E C S S V L P E L A N R T R L F S V C D E R W A D D ECL2ICL3 G T T S A L V R N W K R P S D Q L G D L E Q G L S G E P Q P R A R A ICL3ECL3 G M F R Q A S ECL3N-term M E P S A T P G A Q M G V P P G S R E P S P V P P D Y E D E F L R Y L W R D Y L Y P K Q Y N-termC-term G L G P C G S L K A P S P R S S A S H K S L S L Q S R C S I S K I S E H V V L T S V T T V L P C-term E W V L I A A Y V A V F V V A L V G N T L V C L A V W R N T V T N Y F I V N L S L A D V L V T A I C L P A S L L V D I T E G H A L C K V I P Y L Q A V S V S V A V L T L S F I A L D R W Y A I C H T A R R A R G S I L G I W A V S L A I M V P Q A A V M L Y P K I Y H S C F F I V T Y L A P L G L M A M A Y F Q I F R K L W G R Q I P F L A E V K Q M R A R R K T A K M L M V V L L V F A L C Y L P I S V L N V L K R V F D R E A V Y A C F T F S H W L V Y A N S A A N P I I Y N F L S G K F K A C L P F R E Q A F S C
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Residue Table


GPCRdb(A)
GPCRdb(A)
OX1 receptor
TM2
2x60 2.61x60 S103
TM3
3x29 3.29x29 P123
3x32 3.32x32 Q126
TM5
5x43 5.42x43 F219
TM6
6x51 6.51x51 I314
TM7
7x38 7.39x38 H344