Structure information

M2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6U1N

SPECIES

Homo sapiens

RESOLUTION

4.000

PREFERRED CHAIN

R

REFERENCE

10.1038/S41586-020-1954-0

PUBLICATION DATE

Feb. 26, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
LY2119620 Y83 2.64x63 TM2 hydrophobic
LY2119620 C176 45.50x50 ECL2 polar (hydrogen bond with backbone)
LY2119620 C176 45.50x50 ECL2 Van der Waals
LY2119620 Y177 45.51x51 ECL2 Van der Waals
LY2119620 Y177 45.51x51 ECL2 hydrophobic
LY2119620 I178 45.52x52 ECL2 Van der Waals
LY2119620 F181 ECL2 Van der Waals
LY2119620 N410 6.58x58 TM6 polar (hydrogen bond)
LY2119620 N410 6.58x58 TM6 Van der Waals
LY2119620 A414 ECL3 Van der Waals
LY2119620 A414 ECL3 hydrophobic
LY2119620 P415 ECL3 Van der Waals
LY2119620 N419 ECL3 Van der Waals
LY2119620 N419 ECL3 polar (hydrogen bond with backbone)
LY2119620 W422 7.35x34 TM7 Van der Waals
LY2119620 W422 7.35x34 TM7 aromatic (face-to-face)
LY2119620 W422 7.35x34 TM7 polar (hydrogen bond)

Ligands

LY2119620

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Residue Diagrams

I N G I I T V L S L S G A V L V I F V V 1 F S L A C A D L I I G F V S M N L Y T L Y 2 I L L N M V S A N S V V Y D L A L W L D 3 A G M M I A A A W V L S F I L W A P A I 4 Y L V T M I I V P L Y F A A I A T G F T V 5 L A I L L A F I I T W A P Y N V M V L I 6 A P N I T S N I Y C L W Y G I T W V T 7
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ICL1 R H L Q ICL1ECL1 Y W P L ECL1ICL2 P L T Y P V K R ICL2ECL2 V R T V E D G E C Y I Q F F S ECL2ICL3 P V A N Q D P V S P S L V Q G R I V K P N N N N M P S S D D G L E H N K I Q N G K A P R D P V T E N C V Q G E E K E S S N D S T S V S A V A S N M R D D E I T Q D E N T V S T S L G H S K D E N S K Q T C I R I G T K T P K S D S C T P T N T T V E V V G S S G Q N G D E K Q N I V A R K I V K M T K Q P A K K ICL3ECL3 A P C I ECL3N-term M N N S T N S S N N S L A L T S P Y N-termC-term C H Y K N I G A T R C-term K T F E V V F I V L V A G S L S L V T I I G N I L V M V S I K V N T V N N Y F L F S L A C A D L I I G V F S M N L Y T L Y T V I G G P V V C D L W L A L D Y V V S N A S V M N L L I I S F D R Y F C V T K T T K M A G M M I A A A W V L S F I L W A P A I L F W Q F I V G N A A V T F G T A I A A F Y L P V I I M T V L Y W H I S R A S K S R I K K D K K E K P P P S R E K K V T R T I L A I L L A F I I T W A P Y N V M V L I N T F C P N T V W T I G Y W L C Y I N S T I N P A C Y A L C N A T F K H F K K T L L M
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Residue Table


GPCRdb(A)
GPCRdb(A)
M2 receptor
TM2
2x63 2.64x63 Y83
ECL2
45x50 45.50x50 C176
45x51 45.51x51 Y177
45x52 45.52x52 I178
TM6
6x58 6.58x58 N410
TM7
7x34 7.35x34 W422