Structure information

calcitonin receptor-like receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

6UUN

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

R

PUBLICATION DATE

March 25, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
adrenomedullin F92 N-term hydrophobic
adrenomedullin Q93 N-term polar (hydrogen bond with backbone)
adrenomedullin T120 N-term polar (hydrogen bond with backbone)
adrenomedullin V135 1.33x33 TM1 hydrophobic
adrenomedullin L195 2.68x68 TM2 hydrophobic
adrenomedullin A199 ECL1 hydrophobic
adrenomedullin Q202 ECL1 polar (hydrogen bond)
adrenomedullin M223 3.40x40 TM3 hydrophobic
adrenomedullin I284 45.52x52 ECL2 hydrophobic
adrenomedullin S286 ECL2 polar (hydrogen bond with backbone)
adrenomedullin H289 ECL2 polar (hydrogen bond)
adrenomedullin Y292 5.37x38 TM5 polar (hydrogen bond)
adrenomedullin Y292 5.37x38 TM5 polar (hydrogen bond)
adrenomedullin H295 5.40x40 TM5 polar (hydrogen bond)
adrenomedullin F349 6.53x53 TM6 hydrophobic
adrenomedullin M373 7.46x45 TM7 polar (hydrogen bond)
adrenomedullin M373 7.46x45 TM7 polar (hydrogen bond)

Ligands

adrenomedullin

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Residue Diagrams

L L S A I S L G H G I I T L Y F L N L A 1 K N L F F S F V C N S V V T I I H L T A 2 C L M W F Y N C G M L Y L H I F Q S V K 3 H L M W Y Y F G L W G F P L I P A C I H A 4 L F F L N V L L A A C I P G H I I Y L L H 5 L I L V P L L G I E F V L I P W 6 T S V L L G Q F H M L I H M I Y D Y V 7
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ICL1 K S L S ICL1ECL1 A N N Q A L V A T N P ECL1ICL2 A V F A E K Q ICL2ECL2 N D N C W I S S D ECL2ICL3 V T H Q A E S N L ICL3ECL3 R P E G ECL3N-term M E K K C T L N F L V L L P F F M I L V T A E L E E S P E D S I Q L G V T R N K I M T A Q Y E C Y Q K I M Q D P I Q Q A E G V Y C N R T W D G W L C W N D V A A G T E S M Q L C P D Y F Q D F D P S E K V T K I C D Q D G N W F R H P A S N R T W T N Y T Q C N V N-termC-term E A L R S A S Y T V S T I S D G P G Y S H D C P S E H L N G K S I H D I E N V L L K P E N L Y N C-term N T H E K V K T A L N L F Y L T I I G H G L S I A S L L I S L G I F F Y F C Q R I T L H K N L F F S F V C N S V V T I I H L T A V V S C K V S Q F I H L Y L M G C N Y F W M L C E G I Y L H T L I V V H L M W Y Y F L G W G F P L I P A C I H A I A R S L Y Y T H L L Y I I H G P I C A A L L V N L F F L L N I V R V L I T K L K Y M K A V R A T L I L V P L L G I E F V L I P W K I A E E V Y D Y I M H I L M H F Q G L L V S T I F C F F N G E L R R Y K I S F S V Q A I N W N Q Q F G N N S
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Residue Table


GPCRdb(A)
GPCRdb(B)
calcitonin receptor-like receptor
TM1
1x29 1.33x33 V135
TM2
2x61 2.68x68 L195
TM3
3x36 3.40x40 M223
ECL2
45x52 45.52x52 I284
TM5
5x42 5.37x38 Y292
5x44 5.40x40 H295
TM6
6x48 6.53x53 F349
TM7
7x41 7.46x45 M373