Structure information

5-HT2A receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6WGT

SPECIES

Homo sapiens

RESOLUTION

3.400

PREFERRED CHAIN

B

PUBLICATION DATE

Sept. 23, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Lysergide W151 3.28x28 TM3 hydrophobic
Lysergide D155 3.32x32 TM3 polar (charge-assisted hydrogen bond)
Lysergide V156 3.33x33 TM3 Van der Waals
Lysergide V156 3.33x33 TM3 hydrophobic
Lysergide L229 45.52x52 ECL2 hydrophobic
Lysergide L229 45.52x52 ECL2 Van der Waals
Lysergide F234 5.38x39 TM5 hydrophobic
Lysergide G238 5.42x43 TM5 Van der Waals
Lysergide S242 5.46x461 TM5 Van der Waals
Lysergide S242 5.46x461 TM5 polar (hydrogen bond)
Lysergide W336 6.48x48 TM6 hydrophobic
Lysergide F339 6.51x51 TM6 hydrophobic
Lysergide F339 6.51x51 TM6 Van der Waals
Lysergide F340 6.52x52 TM6 aromatic (edge-to-face)
Lysergide F340 6.52x52 TM6 Van der Waals
Lysergide N343 6.55x55 TM6 Van der Waals
Lysergide V366 7.39x38 TM7 Van der Waals

Ligands

Lysergide

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Residue Diagrams

I N G A I T L I I V V A T L L A S W N K 1 M S L A I A D M L L G L F V M P V S M L T 2 A C L H M I S A T S F L V D L Y I W V A 3 A F L K I I A V W T I S V G I S M P I 4 Y T I V M I T L P I F F S V F S G I L V F 5 G I V F F L F V V M W C P F F I T N I M 6 L P N V A S S L Y G I W V F V N L L A 7
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ICL1 K K L Q ICL1ECL1 Y R W P L ECL1ICL2 P I H H S R F N ICL2ECL2 D S K V F K E G S C L L A ECL2ICL3 G T R A K L A S F S F L P Q S S L S S E K L F Q R S I H R E P G S Y T G R R T ICL3ECL3 K E S C ECL3N-term M D I L C E E N T S L S S T T N S L M Q L N D D T R L Y S N D F N S G E A N T S D A F N W T V D S E N R T N L S C E G C L S P S C L S L N-termC-term Q Y K E N K K P L Q L I L V N T I P A L A Y K S S Q L Q M G Q K K N S K Q D A K T T D N D C S M V A L G K Q H S E E A S K D N S D G V N E K V S C V C-term L H L Q E K N W S A L L T A V V I I L T I A G N I L V I M A V S L E N A T N Y F L M S L A I A D M L L G F L V M P V S M L T I L Y G P S K L C A V W I Y L D V L F S T A S I M H L C A I S L D R Y V A I Q N S R T K A F L K I I A V W T I S V G I S M P I P V F G L Q D D D N F V L I G S F V S F F I P L T I M V I T Y F L T I K S L Q K E A T L C V S D L M Q S I S N E Q K A C K V L G I V F F L F V V M W C P F F I T N I M A V I C N E D V I G A L L N V F V W I G Y L S S A V N P L V Y T L F N K T F S R Y R S A Y I Q C
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Residue Table


GPCRdb(A)
GPCRdb(A)
5-HT2A receptor
TM3
3x28 3.28x28 W151
3x32 3.32x32 D155
3x33 3.33x33 V156
ECL2
45x52 45.52x52 L229
TM5
5x39 5.38x39 F234
5x43 5.42x43 G238
5x461 5.46x461 S242
TM6
6x48 6.48x48 W336
6x51 6.51x51 F339
6x52 6.52x52 F340
6x55 6.55x55 N343
TM7
7x38 7.39x38 V366