Structure information

M1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6WJC

SPECIES

Homo sapiens

RESOLUTION

2.550

PREFERRED CHAIN

A

PUBLICATION DATE

July 8, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Muscarinic toxin 7 W164 4.64x64 TM4 polar (hydrogen bond)
Muscarinic toxin 7 V168 4.68x68 TM4 hydrophobic
Muscarinic toxin 7 E170 ECL2 polar (charge-charge)
Muscarinic toxin 7 E170 ECL2 polar (charge-charge)
Muscarinic toxin 7 E170 ECL2 polar (charge-assisted hydrogen bond)
Muscarinic toxin 7 T172 ECL2 polar (hydrogen bond with backbone)
Muscarinic toxin 7 L174 ECL2 hydrophobic
Muscarinic toxin 7 Y179 45.51x51 ECL2 hydrophobic
Muscarinic toxin 7 F182 ECL2 hydrophobic
Muscarinic toxin 7 P186 5.36x37 TM5 hydrophobic
Muscarinic toxin 7 E397 7.32x31 TM7 polar (charge-charge)
Muscarinic toxin 7 E397 7.32x31 TM7 polar (charge-assisted hydrogen bond)
Muscarinic toxin 7 W400 7.35x34 TM7 hydrophobic
Muscarinic toxin 7 E401 7.36x35 TM7 polar (charge-charge)

Ligands

Muscarinic toxin 7

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Residue Diagrams

L N G T V T A L S L L G T T I G I F A V 1 L S L A C A D L I I G F T S M N L Y T T Y 2 L L L N M V S A N S A V Y D L A L W L D 3 A A L M I G L A W L V S F V L W A P A I 4 Y L T C M V T V P L Y F A A M A T G F T I 5 S A I L L A F I L T W T P Y N I M V L V 6 M P N I T S N V Y C L W Y G L E W L T 7
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ICL1 T E L K ICL1ECL1 H W A L ECL1ICL2 P L S Y R A K R ICL2ECL2 E R T V L A G Q C Y I Q F L S ECL2ICL3 Q G S E T P G K G G G S S S S S E R S Q P G A E G S P E T P P G R C C R C C R A P R L L Q A Y S W K E E E E E D E G S M E S L T S S E G E E P G S E V V I K M P M V D P E A Q A P T K Q P P R S S P N T V K R P T K K G R D R A G K G Q K P R G K E Q L A K R K ICL3ECL3 K D C V ECL3N-term M N T S A P P A V S P N I T V L A P G K G N-termC-term R W D K R R W R K I P K R P G S V H R T P S R Q C C-term P W Q V A F I G I T T G L L S L A T V T G N L L V L I S F K V N T V N N Y F L L S L A C A D L I I G T F S M N L Y T T Y L L M G G T L A C D L W L A L D Y V A S N A S V M N L L L I S F D R Y F S V T R T P R R A A L M I G L A W L V S F V L W A P A I L F W Q Y L V G Q P I I T F G T A M A A F Y L P V T V M C T L Y W R I Y R E T E N R A R E L A A L T F S L V K E K K A A R T L S A I L L A F I L T W T P Y N I M V L V S T F C P E T L W E L G Y W L C Y V N S T I N P M C Y A L C N K A F R L F R D T L L L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
M1 receptor
TM4
4x64 4.64x64 W164
4x68 4.68x68 V168
ECL2
45x51 45.51x51 Y179
TM5
5x37 5.36x37 P186
TM7
7x31 7.32x31 E397
7x34 7.35x34 W400
7x35 7.36x35 E401