Structure information

GLP-1 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

6X18

SPECIES

Homo sapiens

RESOLUTION

2.100

PREFERRED CHAIN

R

PUBLICATION DATE

Sept. 9, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL410972 L32 N-term polar (hydrogen bond with backbone)
CHEMBL410972 V36 N-term hydrophobic
CHEMBL410972 W39 N-term aromatic (face-to-edge)
CHEMBL410972 Y69 N-term hydrophobic
CHEMBL410972 P90 N-term hydrophobic
CHEMBL410972 W91 N-term hydrophobic
CHEMBL410972 R121 N-term polar (charge-assisted hydrogen bond)
CHEMBL410972 P137 N-term hydrophobic
CHEMBL410972 L141 1.36x36 TM1 hydrophobic
CHEMBL410972 L144 1.39x39 TM1 hydrophobic
CHEMBL410972 Y148 1.43x43 TM1 aromatic (edge-to-face)
CHEMBL410972 Y152 1.47x47 TM1 polar (charge-assisted hydrogen bond)
CHEMBL410972 Y152 1.47x47 TM1 polar (hydrogen bond)
CHEMBL410972 R190 2.60x60 TM2 polar (charge-assisted hydrogen bond)
CHEMBL410972 R190 2.60x60 TM2 polar (charge-charge)
CHEMBL410972 R190 2.60x60 TM2 polar (charge-charge)
CHEMBL410972 K197 2.67x67 TM2 polar (charge-assisted hydrogen bond)
CHEMBL410972 L201 2.71x71 TM2 hydrophobic
CHEMBL410972 Y205 ECL1 polar (hydrogen bond)
CHEMBL410972 Y205 ECL1 polar (hydrogen bond)
CHEMBL410972 Q210 ECL1 polar (charge-assisted hydrogen bond)
CHEMBL410972 W214 ECL1 hydrophobic
CHEMBL410972 Q234 3.37x37 TM3 polar (hydrogen bond)
CHEMBL410972 V237 3.40x40 TM3 hydrophobic
CHEMBL410972 Y241 3.44x44 TM3 polar (hydrogen bond)
CHEMBL410972 T298 45.52x52 ECL2 polar (hydrogen bond with backbone)
CHEMBL410972 T298 45.52x52 ECL2 polar (hydrogen bond with backbone)
CHEMBL410972 T298 45.52x52 ECL2 polar (hydrogen bond)
CHEMBL410972 R299 ECL2 polar (charge-assisted hydrogen bond)
CHEMBL410972 R299 ECL2 polar (charge-charge)
CHEMBL410972 R299 ECL2 polar (charge-assisted hydrogen bond)
CHEMBL410972 N300 ECL2 polar (hydrogen bond with backbone)
CHEMBL410972 W306 5.36x37 TM5 aromatic (edge-to-face)
CHEMBL410972 R310 5.40x40 TM5 polar (hydrogen bond with backbone)
CHEMBL410972 R380 7.35x34 TM7 polar (charge-charge)
CHEMBL410972 R380 7.35x34 TM7 polar (charge-charge)
CHEMBL410972 L384 7.39x38 TM7 hydrophobic
CHEMBL410972 L388 7.43x42 TM7 polar (hydrogen bond with backbone)

Ligands

CHEMBL410972

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Residue Diagrams

V L A S F S L A Y G V T Y I I Y L F L L 1 L N L F A S F I L R A L S V F I K D A A 2 V L L W Y Y N A A V C Y Q M L L F V L R 3 I F R L Y V S G I W G V P L L F V V P W G 4 F I L F N V G I A F L I P L R I I L W Y N 5 L T L I P L L G T H E V I F A F V M 6 I A V M L G Q F S T F S L E T F L K I 7
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ICL1 R H L H ICL1ECL1 T A A Q Q H Q W D G L L S Y Q D S ECL1ICL2 S V L ICL2ECL2 D E G C W T R N S ECL2ICL3 M ICL3ECL3 D E H A R ECL3N-term M A G A P G P L R L A L L L L G M V G R A G P R P Q G A T V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E S K R G E R S S P N-termC-term S M K P L K C P T S S L S S G A T A G S S M Y T A T C Q A S C S C-term E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A N L C K T D I K C R L A K S T L T L I P L L G T H E V I F A F V M G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E F R K W R L I Q R V Q L E S W E R E H L H D S
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Residue Table


GPCRdb(A)
GPCRdb(B)
GLP-1 receptor
TM1
1x32 1.36x36 L141
1x35 1.39x39 L144
1x39 1.43x43 Y148
1x43 1.47x47 Y152
TM2
2x53 2.60x60 R190
2x60 2.67x67 K197
2x64 2.71x71 L201
TM3
3x33 3.37x37 Q234
3x36 3.40x40 V237
3x40 3.44x44 Y241
ECL2
45x52 45.52x52 T298
TM5
5x41 5.36x37 W306
5x44 5.40x40 R310
TM7
7x30 7.35x34 R380
7x34 7.39x38 L384
7x38 7.43x42 L388