Structure information

GLP-1 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

6X18

SPECIES

Homo sapiens

RESOLUTION

2.100

PREFERRED CHAIN

R

PUBLICATION DATE

Sept. 9, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
GLP-1 L32 N-term polar (hydrogen bond with backbone)
GLP-1 V36 N-term hydrophobic
GLP-1 W39 N-term aromatic (face-to-edge)
GLP-1 Y69 N-term hydrophobic
GLP-1 P90 N-term hydrophobic
GLP-1 W91 N-term hydrophobic
GLP-1 R121 N-term polar (charge-assisted hydrogen bond)
GLP-1 P137 N-term hydrophobic
GLP-1 L141 1.36x36 TM1 hydrophobic
GLP-1 L144 1.39x39 TM1 hydrophobic
GLP-1 Y148 1.43x43 TM1 aromatic (edge-to-face)
GLP-1 Y152 1.47x47 TM1 polar (charge-assisted hydrogen bond)
GLP-1 Y152 1.47x47 TM1 polar (hydrogen bond)
GLP-1 R190 2.60x60 TM2 polar (charge-assisted hydrogen bond)
GLP-1 R190 2.60x60 TM2 polar (charge-charge)
GLP-1 R190 2.60x60 TM2 polar (charge-charge)
GLP-1 K197 2.67x67 TM2 polar (charge-assisted hydrogen bond)
GLP-1 L201 2.71x71 TM2 hydrophobic
GLP-1 Y205 ECL1 polar (hydrogen bond)
GLP-1 Y205 ECL1 polar (hydrogen bond)
GLP-1 Q210 ECL1 polar (charge-assisted hydrogen bond)
GLP-1 W214 ECL1 hydrophobic
GLP-1 Q234 3.37x37 TM3 polar (hydrogen bond)
GLP-1 V237 3.40x40 TM3 hydrophobic
GLP-1 Y241 3.44x44 TM3 polar (hydrogen bond)
GLP-1 T298 45.52x52 ECL2 polar (hydrogen bond with backbone)
GLP-1 T298 45.52x52 ECL2 polar (hydrogen bond with backbone)
GLP-1 T298 45.52x52 ECL2 polar (hydrogen bond)
GLP-1 R299 ECL2 polar (charge-assisted hydrogen bond)
GLP-1 R299 ECL2 polar (charge-charge)
GLP-1 R299 ECL2 polar (charge-assisted hydrogen bond)
GLP-1 N300 ECL2 polar (hydrogen bond with backbone)
GLP-1 W306 5.36x37 TM5 aromatic (edge-to-face)
GLP-1 R310 5.40x40 TM5 polar (hydrogen bond with backbone)
GLP-1 R380 7.35x34 TM7 polar (charge-charge)
GLP-1 R380 7.35x34 TM7 polar (charge-charge)
GLP-1 L384 7.39x38 TM7 hydrophobic
GLP-1 L388 7.43x42 TM7 polar (hydrogen bond with backbone)

Ligands

GLP-1

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Residue Diagrams

V L A S F S L A Y G V T Y I I Y L F L L 1 L N L F A S F I L R A L S V F I K D A A 2 V L L W Y Y N A A V C Y Q M L L F V L R 3 I F R L Y V S G I W G V P L L F V V P W G 4 F I L F N V G I A F L I P L R I I L W Y N 5 L T L I P L L G T H E V I F A F V M 6 I A V M L G Q F S T F S L E T F L K I 7
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ICL1 R H L H ICL1ECL1 T A A Q Q H Q W D G L L S Y Q D S ECL1ICL2 S V L ICL2ECL2 D E G C W T R N S ECL2ICL3 M ICL3ECL3 D E H A R ECL3N-term M A G A P G P L R L A L L L L G M V G R A G P R P Q G A T V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E S K R G E R S S P N-termC-term S M K P L K C P T S S L S S G A T A G S S M Y T A T C Q A S C S C-term E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A N L C K T D I K C R L A K S T L T L I P L L G T H E V I F A F V M G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E F R K W R L I Q R V Q L E S W E R E H L H D S
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Residue Table


GPCRdb(A)
GPCRdb(B)
GLP-1 receptor
TM1
1x32 1.36x36 L141
1x35 1.39x39 L144
1x39 1.43x43 Y148
1x43 1.47x47 Y152
TM2
2x53 2.60x60 R190
2x60 2.67x67 K197
2x64 2.71x71 L201
TM3
3x33 3.37x37 Q234
3x36 3.40x40 V237
3x40 3.44x44 Y241
ECL2
45x52 45.52x52 T298
TM5
5x41 5.36x37 W306
5x44 5.40x40 R310
TM7
7x30 7.35x34 R380
7x34 7.39x38 L384
7x38 7.43x42 L388