Structure information

NTS1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6Z4S

SPECIES

Rattus norvegicus

RESOLUTION

2.710

PREFERRED CHAIN

A

REFERENCE

10.1126/sciadv.abe5504

PUBLICATION DATE

Feb. 10, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
meclinertant Y146 3.29x29 TM3 polar (hydrogen bond)
meclinertant M208 4.64x65 TM4 polar (hydrogen bond)
meclinertant P227 45.52x52 ECL2 Van der Waals
meclinertant L234 5.35x36 TM5 Van der Waals
meclinertant L234 5.35x36 TM5 hydrophobic
meclinertant I238 5.39x40 TM5 hydrophobic
meclinertant I238 5.39x40 TM5 Van der Waals
meclinertant R327 6.54x54 TM6 polar (hydrogen bond with backbone)
meclinertant R327 6.54x54 TM6 polar (charge-assisted hydrogen bond)
meclinertant R328 6.55x55 TM6 polar (charge-assisted hydrogen bond)
meclinertant M330 6.57x57 TM6 polar (hydrogen bond)
meclinertant F331 6.58x58 TM6 polar (hydrogen bond with backbone)
meclinertant F331 6.58x58 TM6 polar (hydrogen bond)
meclinertant I334 ECL3 hydrophobic
meclinertant I334 ECL3 Van der Waals
meclinertant W339 ECL3 Van der Waals
meclinertant F344 7.28x27 TM7 hydrophobic
meclinertant F344 7.28x27 TM7 Van der Waals
meclinertant Y347 7.31x30 TM7 aromatic (face-to-edge)
meclinertant Y347 7.31x30 TM7 Van der Waals
meclinertant Y347 7.31x30 TM7 polar (hydrogen bond with backbone)
meclinertant H348 7.32x31 TM7 Van der Waals
meclinertant H348 7.32x31 TM7 polar (hydrogen bond with backbone)
meclinertant F350 7.34x33 TM7 Van der Waals
meclinertant Y351 7.35x34 TM7 aromatic (edge-to-face)
meclinertant Y351 7.35x34 TM7 polar (hydrogen bond with backbone)
meclinertant Y351 7.35x34 TM7 polar (hydrogen bond)

Ligands

meclinertant

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Residue Diagrams

S N G V T G V V F L A L Y I A T V L V K 1 G S L A L S D L L I L L L A M P V E L Y N 2 S A V N L A T A Y T C A D R L F Y Y G R 3 T K K F I S A I W L A S A L L A I P M 4 N L I S I V L M P F L F S M F T N V Q I V 5 R A V V I A F V V C W L P Y H V R R L M 6 I P N I A S S V Y F L A N T L M Y F Y 7
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ICL1 K S L Q ICL1ECL1 H H P W A F ECL1ICL2 P F K A K T L M ICL2ECL2 G L Q N R S G D G T H P G G L V C T P I V D ECL2ICL3 R V C T V G T H N G L E H S T F N M T I E ICL3ECL3 S D E Q W ECL3N-term M H L N S S V P Q G T P G E P D A Q P F S G P Q S E M E A T F L A L S L S N G S G N T S E S D T A G P N S D L D V N T D N-termC-term P G W R H R R K K R P T F S R K P N S M S S N H A F S T S A T R E T L Y C-term I Y S K V L V T A I Y L A L F V V G T V G N S V T A F T L A R K S L Q S T V H Y H L G S L A L S D L L I L L L A M P V E L Y N F I W V G D A G C R G Y Y F L R D A C T Y A T A L N V A S L S V E R Y L A I C H S R S R T K K F I S A I W L A S A L L A I P M L F T M T A T V K V V I Q V N T F M S F L F P M L V I S I L N T V I A N K L T V M V H Q A A E Q G P G R V Q A L R H G V L V L R A V V I A F V V C W L P Y H V R R L M F C Y I T T F L F D F Y H Y F Y M L T N A L F Y V S S A I N P I L Y N L V S A N F L S L C F R Q V T L A C
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Residue Table


GPCRdb(A)
GPCRdb(A)
NTS1 receptor
TM3
3x29 3.29x29 Y146
TM4
4x65 4.64x65 M208
ECL2
45x52 45.52x52 P227
TM5
5x36 5.35x36 V234
5x40 5.39x40 I238
TM6
6x54 6.54x54 R327
6x55 6.55x55 R328
6x57 6.57x57 M330
6x58 6.58x58 F331
TM7
7x27 7.28x27 F344
7x30 7.31x30 Y347
7x31 7.32x31 H348
7x33 7.34x33 F350
7x34 7.35x34 Y351