Structure information

STE2

PROTEIN CLASS

Class D1 (Ste2-like fungal pheromone)

PDB CODE

7AD3

SPECIES

Saccharomyces cerevisiae

RESOLUTION

3.500

PREFERRED CHAIN

A

REFERENCE

10.1038/S41586-020-2994-1

PUBLICATION DATE

Dec. 9, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Alpha-factor mating pheromone Q51 1.41x41 TM1 polar (hydrogen bond)
Alpha-factor mating pheromone Q51 1.41x41 TM1 polar (hydrogen bond)
Alpha-factor mating pheromone F55 1.45x45 TM1 Van der Waals
Alpha-factor mating pheromone H94 2.56x56 TM2 polar (hydrogen bond)
Alpha-factor mating pheromone H94 2.56x56 TM2 Van der Waals
Alpha-factor mating pheromone Y98 2.60x60 TM2 Van der Waals
Alpha-factor mating pheromone Y98 2.60x60 TM2 polar (hydrogen bond)
Alpha-factor mating pheromone Y101 2.63x63 TM2 Van der Waals
Alpha-factor mating pheromone Y101 2.63x63 TM2 hydrophobic
Alpha-factor mating pheromone Y106 D1e1.46x46 D1e1 Van der Waals
Alpha-factor mating pheromone Y106 D1e1.46x46 D1e1 hydrophobic
Alpha-factor mating pheromone Y128 3.29x29 TM3 Van der Waals
Alpha-factor mating pheromone Y128 3.29x29 TM3 hydrophobic
Alpha-factor mating pheromone T131 3.32x32 TM3 Van der Waals
Alpha-factor mating pheromone N132 3.33x33 TM3 Van der Waals
Alpha-factor mating pheromone N132 3.33x33 TM3 polar (hydrogen bond)
Alpha-factor mating pheromone Q135 3.36x36 TM3 Van der Waals
Alpha-factor mating pheromone Q135 3.36x36 TM3 polar (hydrogen bond)
Alpha-factor mating pheromone Y181 4.61x61 TM4 Van der Waals
Alpha-factor mating pheromone S184 4.64x64 TM4 Van der Waals
Alpha-factor mating pheromone S197 ECL2 Van der Waals
Alpha-factor mating pheromone A198 ECL2 Van der Waals
Alpha-factor mating pheromone A198 ECL2 polar (hydrogen bond with backbone)
Alpha-factor mating pheromone T199 ECL2 Van der Waals
Alpha-factor mating pheromone D201 5.25x25 TM5 polar (charge-assisted hydrogen bond)
Alpha-factor mating pheromone K202 5.26x26 TM5 Van der Waals
Alpha-factor mating pheromone F204 5.28x28 TM5 Van der Waals
Alpha-factor mating pheromone F204 5.28x28 TM5 aromatic (edge-to-face)
Alpha-factor mating pheromone N205 5.29x29 TM5 polar (hydrogen bond)
Alpha-factor mating pheromone N205 5.29x29 TM5 polar (hydrogen bond)
Alpha-factor mating pheromone N205 5.29x29 TM5 polar (hydrogen bond)
Alpha-factor mating pheromone I209 5.33x33 TM5 Van der Waals
Alpha-factor mating pheromone A265 6.57x57 TM6 Van der Waals
Alpha-factor mating pheromone Y266 6.58x58 TM6 polar (hydrogen bond with backbone)
Alpha-factor mating pheromone Y266 6.58x58 TM6 Van der Waals
Alpha-factor mating pheromone L268 6.60x60 TM6 Van der Waals
Alpha-factor mating pheromone L268 6.60x60 TM6 polar (hydrogen bond with backbone)
Alpha-factor mating pheromone P270 ECL3 Van der Waals
Alpha-factor mating pheromone P270 ECL3 hydrophobic
Alpha-factor mating pheromone D275 ECL3 polar (charge-assisted hydrogen bond)
Alpha-factor mating pheromone V276 7.36x36 TM7 hydrophobic
Alpha-factor mating pheromone V276 7.36x36 TM7 Van der Waals
Alpha-factor mating pheromone T278 7.38x38 TM7 Van der Waals
Alpha-factor mating pheromone T279 7.39x39 TM7 Van der Waals

Ligands

Alpha-factor mating pheromone

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Residue Diagrams

A A A G C R V G F M I A Q T V T S N V L 1 Q V S L F L I I L H S A L Y F K Y L L S 2 T E I S A V L L V Q I I N T A G Y V H V 3 S F T L G I A T V T M Y F V S A V K G M 4 S M F N I S S A L L I T S A N F Y K D 5 C Q S L L V P S I I F I L A Y S L 6 S L V A L L T A V T T L V 7
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ICL1 S R S R K ICL1D1e1 N Y S S V T Y A L T G F P Q F I D1e1ICL2 G D N F K ICL2ECL2 V S A T Q ECL2ICL3 G L K Q F ICL3ECL3 K P N Q G T D ECL3N-term M S D A A P S L S N L F Y D P T Y N P G Q S T I N Y T S I Y G N G S T I N-termC-term T I T S D F T T S T D R F Y P G T L S S F Q T D S I N N D A K S S L R S R L Y D L Y P R R K E T T S D K H S E R T F V S E T A D D I E K N Q F Y Q L P T P T S S K N T R I G P F A D A S Y K E G E V E P V D M Y T P D T A A D E E A R K F W T E D N N N L C-term T F D E L Q G L V N S T V T Q A I M F G V R C G A A A L T L I V M W M T T P I F I I N Q V S L F L I I L H S A L Y F K Y L L S S R G D V H V Y G A T N I I Q V L L V A S I E T S L V F Q I K V I F T R I G L M L T S I S F T L G I A T V T M Y F V S A V K G M I V T Y N D D K Y F N A S T I L L A S S I N F M S F V L V V K L I L A I R S R R F L D S F H I L L I M S C Q S L L V P S I I F I L A Y S L V L T T V A T L L A V L S L P L S S M W A T A A N N A S K T N
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Residue Table


GPCRdb(A)
GPCRdb(D)
STE2
TM1
1x39 1.41x41 Q51
1x43 1.45x45 F55
TM2
2x53 2.56x56 H94
2x57 2.60x60 Y98
2x60 2.63x63 Y101
D1e1
D1e1x46 D1e1.46x46 Y106
TM3
3x29 3.29x29 Y128
3x32 3.32x32 T131
3x33 3.33x33 N132
3x36 3.36x36 Q135
TM4
4x53 4.61x61 Y181
4x56 4.64x64 S184
TM5
5x40 5.25x25 D201
5x41 5.26x26 K202
5x43 5.28x28 F204
5x44 5.29x29 N205
5x48 5.33x33 I209
TM6
6x51 6.57x57 A265
6x52 6.58x58 Y266
6x54 6.60x60 L268
TM7
7x39 7.36x36 V276
7x41 7.38x38 T278
7x42 7.39x39 T279