Structure information

β1-adrenoceptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7BU6

SPECIES

Homo sapiens

RESOLUTION

2.700

PREFERRED CHAIN

A

REFERENCE

10.1038/S41422-020-00424-2

PUBLICATION DATE

Dec. 2, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Noradrenaline D1138 3.32x32 TM3 polar (charge-charge)
Noradrenaline D1138 3.32x32 TM3 polar (charge-assisted hydrogen bond)
Noradrenaline V1139 3.33x33 TM3 Van der Waals
Noradrenaline V1139 3.33x33 TM3 hydrophobic
Noradrenaline V1142 3.36x36 TM3 Van der Waals
Noradrenaline V1142 3.36x36 TM3 hydrophobic
Noradrenaline F1218 45.52x52 ECL2 Van der Waals
Noradrenaline F1218 45.52x52 ECL2 aromatic (face-to-edge)
Noradrenaline S1228 5.42x43 TM5 polar (hydrogen bond)
Noradrenaline S1228 5.42x43 TM5 polar (hydrogen bond with backbone)
Noradrenaline S1228 5.42x43 TM5 Van der Waals
Noradrenaline S1232 5.46x461 TM5 polar (hydrogen bond)
Noradrenaline S1232 5.46x461 TM5 Van der Waals
Noradrenaline F1340 6.51x51 TM6 Van der Waals
Noradrenaline F1340 6.51x51 TM6 aromatic (edge-to-face)
Noradrenaline F1341 6.52x52 TM6 Van der Waals
Noradrenaline F1341 6.52x52 TM6 aromatic (edge-to-face)
Noradrenaline N1344 6.55x55 TM6 polar (hydrogen bond)
Noradrenaline N1344 6.55x55 TM6 Van der Waals
Noradrenaline N1363 7.39x38 TM7 polar (charge-assisted hydrogen bond)
Noradrenaline Y1367 7.43x42 TM7 Van der Waals

Ligands

Noradrenaline

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Residue Diagrams

V N G A V I L L V I L A M L L G M G A T 1 M S L A S A D L V M G L L V V P F G A T I 2 V C L T E I S A T V C L V D V S T W L E 3 A R G L V C T V W A I S A L V S F L P I 4 Y V F A M I C L P V Y F S V V S S A I A Y 5 G I I M G V F T L C W L P F F L A N V V 6 I P N F A S N A Y G L W N F F V F L R 7
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ICL1 P R L Q ICL1ECL1 R W E Y ECL1ICL2 P F R Y Q S L L ICL2ECL2 W W R A E S D E A R R C Y N D P K C C D F V T ECL2ICL3 C E R R F L G G P A R P P S P S P S P V P A P A P P P G P P R P A A A A A T A P L A N G R A G K R R P S ICL3ECL3 R E L V ECL3N-term M G A G V L V L G A S E P G N L S S A A P L P D G A A T A A R L L V P A S P P A S L L P P A S E S N-termC-term C A R R A A R R R H A T H G D R P R A S G C L A R P G P P P S P G A A S D D D D D D V V G A T P P A R L L E P W A G C N G G A A A D S D S S L D E P C R P G F A S E S K V C-term P E P L S Q Q W T A G M G L L M A L I V L L I V A G N V L V I V A I A K T T L T N L F I M S L A S A D L V M G L L V V P F G A T I V V W G G S F F C E L W T S V D V L C V T A S I E T L C V I A L D R Y L A I T S T R A R A R G L V C T V W A I S A L V S F L P I L M H N R A Y A I A S S V V S F Y V P L C I M A F V Y L R V F R E A Q K Q V K K I D S R L V A L R E Q K A L K T L G I I M G V F T L C W L P F F L A N V V K A F H P D R L F V F F N W L G Y A N S A F N P I I Y C R S P D F Q R F R K A L L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
β1-adrenoceptor
TM3
3x32 3.32x32 D138
3x33 3.33x33 V139
3x36 3.36x36 V142
ECL2
45x52 45.52x52 F218
TM5
5x43 5.42x43 S228
5x461 5.46x461 S232
TM6
6x51 6.51x51 F340
6x52 6.52x52 F341
6x55 6.55x55 N344
TM7
7x38 7.39x38 N363
7x42 7.43x42 Y367