Structure information

β1-adrenoceptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7BVQ

SPECIES

Homo sapiens

RESOLUTION

2.500

PREFERRED CHAIN

A

PUBLICATION DATE

Dec. 2, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Carazolol W1134 3.28x28 TM3 hydrophobic
Carazolol D1138 3.32x32 TM3 polar (charge-assisted hydrogen bond)
Carazolol D1138 3.32x32 TM3 polar (charge-charge)
Carazolol V1139 3.33x33 TM3 hydrophobic
Carazolol V1142 3.36x36 TM3 hydrophobic
Carazolol F1218 45.52x52 ECL2 aromatic (edge-to-face)
Carazolol Y1224 5.38x39 TM5 hydrophobic
Carazolol S1228 5.42x43 TM5 polar (hydrogen bond)
Carazolol F1340 6.51x51 TM6 hydrophobic
Carazolol F1341 6.52x52 TM6 aromatic (edge-to-face)
Carazolol N1363 7.39x38 TM7 polar (charge-assisted hydrogen bond)

Ligands

Carazolol

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Residue Diagrams

V N G A V I L L V I L A M L L G M G A T 1 M S L A S A D L V M G L L V V P F G A T I 2 V C L T E I S A T V C L V D V S T W L E 3 A R G L V C T V W A I S A L V S F L P I 4 Y V F A M I C L P V Y F S V V S S A I A Y 5 G I I M G V F T L C W L P F F L A N V V 6 I P N F A S N A Y G L W N F F V F L R 7
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ICL1 P R L Q ICL1ECL1 R W E Y ECL1ICL2 P F R Y Q S L L ICL2ECL2 W W R A E S D E A R R C Y N D P K C C D F V T ECL2ICL3 C E R R F L G G P A R P P S P S P S P V P A P A P P P G P P R P A A A A A T A P L A N G R A G K R R P S ICL3ECL3 R E L V ECL3N-term M G A G V L V L G A S E P G N L S S A A P L P D G A A T A A R L L V P A S P P A S L L P P A S E S N-termC-term C A R R A A R R R H A T H G D R P R A S G C L A R P G P P P S P G A A S D D D D D D V V G A T P P A R L L E P W A G C N G G A A A D S D S S L D E P C R P G F A S E S K V C-term P E P L S Q Q W T A G M G L L M A L I V L L I V A G N V L V I V A I A K T T L T N L F I M S L A S A D L V M G L L V V P F G A T I V V W G G S F F C E L W T S V D V L C V T A S I E T L C V I A L D R Y L A I T S T R A R A R G L V C T V W A I S A L V S F L P I L M H N R A Y A I A S S V V S F Y V P L C I M A F V Y L R V F R E A Q K Q V K K I D S R L V A L R E Q K A L K T L G I I M G V F T L C W L P F F L A N V V K A F H P D R L F V F F N W L G Y A N S A F N P I I Y C R S P D F Q R F R K A L L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
β1-adrenoceptor
TM3
3x28 3.28x28 W134
3x32 3.32x32 D138
3x33 3.33x33 V139
3x36 3.36x36 V142
ECL2
45x52 45.52x52 F218
TM5
5x39 5.38x39 Y224
5x43 5.42x43 S228
TM6
6x51 6.51x51 F340
6x52 6.52x52 F341
TM7
7x38 7.39x38 N363