Structure information

AT2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7C6A

SPECIES

Homo sapiens

RESOLUTION

3.400

PREFERRED CHAIN

A

REFERENCE

10.1038/S41598-020-68355-X

PUBLICATION DATE

July 29, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL404594 W100 2.60x60 TM2 hydrophobic
CHEMBL404594 Y103 2.63x63 TM2 polar (hydrogen bond)
CHEMBL404594 Y103 2.63x63 TM2 Van der Waals
CHEMBL404594 Y104 2.64x64 TM2 hydrophobic
CHEMBL404594 Y104 2.64x64 TM2 Van der Waals
CHEMBL404594 Y108 ECL1 Van der Waals
CHEMBL404594 Y108 ECL1 hydrophobic
CHEMBL404594 L124 3.32x32 TM3 hydrophobic
CHEMBL404594 L124 3.32x32 TM3 Van der Waals
CHEMBL404594 R182 4.64x65 TM4 polar (charge-assisted hydrogen bond)
CHEMBL404594 I187 ECL2 Van der Waals
CHEMBL404594 I187 ECL2 hydrophobic
CHEMBL404594 E188 ECL2 polar (charge-assisted hydrogen bond)
CHEMBL404594 Y189 ECL2 hydrophobic
CHEMBL404594 Y189 ECL2 Van der Waals
CHEMBL404594 C195 45.50x50 ECL2 Van der Waals
CHEMBL404594 C195 45.50x50 ECL2 polar (hydrogen bond with backbone)
CHEMBL404594 I196 45.51x51 ECL2 hydrophobic
CHEMBL404594 I196 45.51x51 ECL2 Van der Waals
CHEMBL404594 M197 45.52x52 ECL2 polar (hydrogen bond with backbone)
CHEMBL404594 M197 45.52x52 ECL2 Van der Waals
CHEMBL404594 Y204 5.31x32 TM5 polar (hydrogen bond)
CHEMBL404594 S208 5.35x36 TM5 Van der Waals
CHEMBL404594 K215 5.42x43 TM5 polar (charge-assisted hydrogen bond)
CHEMBL404594 F272 6.51x51 TM6 hydrophobic
CHEMBL404594 F272 6.51x51 TM6 Van der Waals
CHEMBL404594 D279 6.58x58 TM6 polar (charge-assisted hydrogen bond)
CHEMBL404594 W283 6.62x62 TM6 hydrophobic
CHEMBL404594 W283 6.62x62 TM6 Van der Waals
CHEMBL404594 I293 7.28x27 TM7 Van der Waals
CHEMBL404594 D297 7.32x31 TM7 polar (charge-assisted hydrogen bond)
CHEMBL404594 L300 7.35x34 TM7 hydrophobic
CHEMBL404594 L300 7.35x34 TM7 Van der Waals
CHEMBL404594 P301 7.36x35 TM7 Van der Waals
CHEMBL404594 I304 7.39x38 TM7 hydrophobic
CHEMBL404594 I304 7.39x38 TM7 Van der Waals
CHEMBL404594 F308 7.43x42 TM7 Van der Waals
CHEMBL404594 F308 7.43x42 TM7 hydrophobic

Ligands

CHEMBL404594

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Residue Diagrams

I N V L F G I V F I I Y Y L I P I A D 1 F N L A V A D L L L L A T L P L W A T Y 2 C T I F F I S A F M N L T L F S G F V K 3 A S Y I V P L V W C M A C L S S L P T 4 Y C T A I F I L P I I F G L I N K M L A I 5 A A V V L A F I I C W L P F H V L T F L 6 F P N V C S N T F G L L I A F P L A L 7
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ICL1 K G P K K ICL1ECL1 Y D W L F ECL1ICL2 P F L S Q R R ICL2ECL2 D V R T I E Y L G V N A C I M A F P P E ECL2ICL3 N S Y ICL3ECL3 V I N ECL3N-term M K G N S T L A T T S K N I T S G L H F G L V N I S G N N E S T L N C S Q K P S D K H L N-termC-term I T W L Q G K R E S M S C R K S S S L R E M E T F V S C-term D A I P I L Y Y I I F V I G F L V N I V V V T L F C C Q V S S I Y I F N L A V A D L L L L A T L P L W A T Y Y S Y R G P V M C K V F G S F L T L N M F A S I F F I T C M S V D R Y Q S V I Y N P W Q A S Y I V P L V W C M A C L S S L P T F Y F R K Y A Q W S A G I A L M K N I L G F I I P L I F I A T C Y F G I R K H L L K T G K N R I T R D Q V L K M A A A V V L A F I I C W L P F H V L T F L D A L A W M G S C E V I A V I D L A L P F A I L L G F T N S C V N P F L Y C F V G N R L R S P F Q Q K V F R V
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Residue Table


GPCRdb(A)
GPCRdb(A)
AT2 receptor
TM2
2x60 2.60x60 W100
2x63 2.63x63 Y103
2x64 2.64x64 Y104
TM3
3x32 3.32x32 L124
TM4
4x65 4.64x65 R182
ECL2
45x50 45.50x50 C195
45x51 45.51x51 I196
45x52 45.52x52 M197
TM5
5x32 5.31x32 Y204
5x36 5.35x36 S208
5x43 5.42x43 K215
TM6
6x51 6.51x51 F272
6x58 6.58x58 D279
6x62 6.62x62 W283
TM7
7x27 7.28x27 I293
7x31 7.32x31 D297
7x34 7.35x34 L300
7x35 7.36x35 P301
7x38 7.39x38 I304
7x42 7.43x42 F308