GPCRdb

Ligand	Amino Acid	Generic Number	Segment	Interaction Type


SI	W100	2.60x60	TM2	hydrophobic
SI	Y103	2.63x63	TM2	polar (hydrogen bond)
SI	Y103	2.63x63	TM2	Van der Waals
SI	Y104	2.64x64	TM2	hydrophobic
SI	Y104	2.64x64	TM2	Van der Waals
SI	Y108		ECL1	Van der Waals
SI	Y108		ECL1	hydrophobic
SI	L124	3.32x32	TM3	hydrophobic
SI	L124	3.32x32	TM3	Van der Waals
SI	R182	4.64x65	TM4	polar (charge-assisted hydrogen bond)
SI	I187		ECL2	Van der Waals
SI	I187		ECL2	hydrophobic
SI	E188		ECL2	polar (charge-assisted hydrogen bond)
SI	Y189		ECL2	hydrophobic
SI	Y189		ECL2	Van der Waals
SI	C195	45.50x50	ECL2	Van der Waals
SI	C195	45.50x50	ECL2	polar (hydrogen bond with backbone)
SI	I196	45.51x51	ECL2	hydrophobic
SI	I196	45.51x51	ECL2	Van der Waals
SI	M197	45.52x52	ECL2	polar (hydrogen bond with backbone)
SI	M197	45.52x52	ECL2	Van der Waals
SI	Y204	5.31x32	TM5	polar (hydrogen bond)
SI	S208	5.35x36	TM5	Van der Waals
SI	K215	5.42x43	TM5	polar (charge-assisted hydrogen bond)
SI	F272	6.51x51	TM6	hydrophobic
SI	F272	6.51x51	TM6	Van der Waals
SI	D279	6.58x58	TM6	polar (charge-assisted hydrogen bond)
SI	W283	6.62x62	TM6	hydrophobic
SI	W283	6.62x62	TM6	Van der Waals
SI	I293	7.28x27	TM7	Van der Waals
SI	D297	7.32x31	TM7	polar (charge-assisted hydrogen bond)
SI	L300	7.35x34	TM7	hydrophobic
SI	L300	7.35x34	TM7	Van der Waals
SI	P301	7.36x35	TM7	Van der Waals
SI	I304	7.39x38	TM7	hydrophobic
SI	I304	7.39x38	TM7	Van der Waals
SI	F308	7.43x42	TM7	Van der Waals
SI	F308	7.43x42	TM7	hydrophobic