Structure information

D3 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7CMU

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

R

PUBLICATION DATE

March 10, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Pramipexole D110 3.32x32 TM3 polar (charge-charge)
Pramipexole V111 3.33x33 TM3 hydrophobic
Pramipexole S192 5.42x43 TM5 polar (hydrogen bond with backbone)
Pramipexole F345 6.51x51 TM6 hydrophobic
Pramipexole F346 6.52x52 TM6 aromatic (edge-to-face)
Pramipexole Y373 7.43x42 TM7 hydrophobic

Ligands

Pramipexole

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Residue Diagrams

G N G F V I A L I L A C Y S L A Y Y A H 1 V S L A V A D L L V A L T V M P W V V Y L 2 A C L N L I S A T C M M V D L T V F V D 3 V A L M I T A V W V L A F A V S C P L 4 Y V L V T V G F P L Y F S V V S S Y I V F 5 A I V L G A F I V C W L P F F L T H V L 6 V P N L A S N V Y G L W T T A S Y L E 7
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ICL1 R A L Q ICL1ECL1 G V W N F ECL1ICL2 P V H Y Q H G T G Q S ICL2ECL2 F N T T G D P T V C S I S ECL2ICL3 Q N S Q C N S V R P G F P Q Q T L S P D P A H L E L K R Y Y S I C Q D T A L G G P G F Q E R G G E L K R E E K T R N S L S P T I A P K L S L E V R K L S N G R L S T S L K L G P L Q P ICL3ECL3 Q T C H V ECL3N-term M A S L S Q L S S H L N Y T C G A E N S T G A S Q N-termC-term C C-term A R P H A Y Y A L S Y C A L I L A I V F G N G L V C M A V L K E T T T N Y L V V S L A V A D L L V A T L V M P W V V Y L E V T G S R I C C D V F V T L D V M M C T A S I L N L C A I S I D R Y T A V V M S C R R V A L M I T A V W V L A F A V S C P L L F G N P D F V I Y S S V V S F Y L P F G V T V L V Y A R I Y V V L K Q R R R K R I L T R R G V P L R E K K A T Q M V A I V L G A F I V C W L P F F L T H V L N T H C S P E L Y S A T T W L G Y V N S A L N P V I Y T T F N I E F L K F R K A I L S
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Residue Table


GPCRdb(A)
GPCRdb(A)
D3 receptor
TM3
3x32 3.32x32 D110
3x33 3.33x33 V111
TM5
5x43 5.42x43 S192
TM6
6x51 6.51x51 F345
6x52 6.52x52 F346
TM7
7x42 7.43x42 Y373