Structure information

D3 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7CMV

SPECIES

Homo sapiens

RESOLUTION

2.700

PREFERRED CHAIN

R

REFERENCE

10.1016/J.MOLCEL.2021.01.003

PUBLICATION DATE

March 10, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL70565 D110 3.32x32 TM3 polar (charge-assisted hydrogen bond)
CHEMBL70565 V111 3.33x33 TM3 hydrophobic
CHEMBL70565 V111 3.33x33 TM3 Van der Waals
CHEMBL70565 C114 3.36x36 TM3 Van der Waals
CHEMBL70565 S192 5.42x43 TM5 polar (hydrogen bond)
CHEMBL70565 S192 5.42x43 TM5 Van der Waals
CHEMBL70565 W342 6.48x48 TM6 Van der Waals
CHEMBL70565 W342 6.48x48 TM6 hydrophobic
CHEMBL70565 F345 6.51x51 TM6 hydrophobic
CHEMBL70565 F345 6.51x51 TM6 Van der Waals
CHEMBL70565 F346 6.52x52 TM6 hydrophobic
CHEMBL70565 H349 6.55x55 TM6 Van der Waals
CHEMBL70565 G372 7.42x41 TM7 Van der Waals
CHEMBL70565 Y373 7.43x42 TM7 Van der Waals

Ligands

CHEMBL70565

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Residue Diagrams

G N G F V I A L I L A C Y S L A Y Y A H 1 V S L A V A D L L V A L T V M P W V V Y L 2 A C L N L I S A T C M M V D L T V F V D 3 V A L M I T A V W V L A F A V S C P L 4 Y V L V T V G F P L Y F S V V S S Y I V F 5 A I V L G A F I V C W L P F F L T H V L 6 V P N L A S N V Y G L W T T A S Y L E 7
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ICL1 R A L Q ICL1ECL1 G V W N F ECL1ICL2 P V H Y Q H G T G Q S ICL2ECL2 F N T T G D P T V C S I S ECL2ICL3 Q N S Q C N S V R P G F P Q Q T L S P D P A H L E L K R Y Y S I C Q D T A L G G P G F Q E R G G E L K R E E K T R N S L S P T I A P K L S L E V R K L S N G R L S T S L K L G P L Q P ICL3ECL3 Q T C H V ECL3N-term M A S L S Q L S G H L N Y T C G A E N S T G A S Q N-termC-term C C-term A R P H A Y Y A L S Y C A L I L A I V F G N G L V C M A V L K E T T T N Y L V V S L A V A D L L V A T L V M P W V V Y L E V T G S R I C C D V F V T L D V M M C T A S I L N L C A I S I D R Y T A V V M S C R R V A L M I T A V W V L A F A V S C P L L F G N P D F V I Y S S V V S F Y L P F G V T V L V Y A R I Y V V L K Q R R R K R I L T R R G V P L R E K K A T Q M V A I V L G A F I V C W L P F F L T H V L N T H C S P E L Y S A T T W L G Y V N S A L N P V I Y T T F N I E F L K F R K A I L S
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Residue Table


GPCRdb(A)
GPCRdb(A)
D3 receptor
TM3
3x32 3.32x32 D110
3x33 3.33x33 V111
3x36 3.36x36 C114
TM5
5x43 5.42x43 S192
TM6
6x48 6.48x48 W342
6x51 6.51x51 F345
6x52 6.52x52 F346
6x55 6.55x55 H349
TM7
7x41 7.42x41 G372
7x42 7.43x42 Y373