Structure information

GABAB2

PROTEIN CLASS

Class C (Glutamate)

PDB CODE

7CUM

SPECIES

Homo sapiens

RESOLUTION

3.520

PREFERRED CHAIN

B

PUBLICATION DATE

Nov. 11, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CGP54626 W182 N-term hydrophobic
CGP54626 S247 N-term polar (hydrogen bond with backbone)
CGP54626 S270 N-term polar (hydrogen bond)
CGP54626 S270 N-term polar (hydrogen bond)
CGP54626 W395 N-term hydrophobic
CGP54626 E466 N-term polar (charge-charge)
Unknown ligand L647 ECL2 polar (hydrogen bond with backbone)
Unknown ligand R666 5.49x49 TM5 polar (charge-assisted hydrogen bond)
Unknown ligand L667 5.50x50 TM5 hydrophobic
Unknown ligand L670 5.53x53 TM5 hydrophobic
Unknown ligand F674 5.57x57 TM5 hydrophobic
Unknown ligand C761 polar (hydrogen bond with backbone)
Unknown ligand F773 hydrophobic
Unknown ligand A820 hydrophobic
Unknown ligand I841 hydrophobic

Ligands

CGP54626

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Unknown ligand

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Residue Diagrams

S A M I M G L I T L A S L I S Y L P L S 1 N L I I L G G M L S Y A S I F L F G L 2 A F M A G F A T T Y G V T L I W T R V T 3 L L V I V G G M L L I D L C I L I C W Q 4 A L F C G F L M L L G K Y A Y V I G L W 5 G M S V Y N V G I M C I I G A A V S F L 6 C L T I T S C F I I V L A V I C F Q V N 7
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ICL1 Q R N K L I K M S ICL1ECL1 D G S F V ECL1ICL2 N V K M K K K I I ICL2ECL2 P L R R T V E K Y S M E P D P A G R D I S I R P L L E H C E N T ECL2ICL3 S I P A L N ICL3ECL3 R D ECL3N-term M A S P R S S G Q P G P P P P P P P P P A R L L L L L L L P L L L P L A P G A W G W A R G A P R P P P S S P P L S I M G L M P L T K E V A K G S I G R G V L P A V E L A I E Q I R N E S L L R P Y F L D L R L Y D T E C D N A K G L K A F Y D A I K Y G P N H L M V F G G V C P S V T S I I A E S L Q G W N L V Q L S F A A T T P V L A D K K K Y P Y F F R T V P S D N A V N P A I L K L L K H Y Q W K R V G T L T Q D V Q R F S E V R N D L T G V L Y G E D I E I S D T E S F S N D P C T S V K K L K G N D V R I I L G Q F D Q N M A A K V F C C A Y E E N M Y G S K Y Q W I I P G W Y E P S W W E Q V H T E A N S S R C L R K N L L A A M E G Y I G V D F E P L S S K Q I K T I S G K T P Q Q Y E R E Y N N K R S G V G P S K F H G Y A Y D G I W V I A K T L Q R A M E T L H A S S R H Q R I Q D F N Y T D H T L G R I I L N A M N E T N F F G V T G Q V V F R N G E R M G T I K F T Q F Q D S R E V K V G E Y N A V A D T L E I I N D T I R F Q G S E P P K D K T I I L E Q L R K I N-termC-term T Q N Q K K E D S K T S T S V T S V N Q A S T S R L E G L Q S E N H R L R M K I T E L D K D L E E V T M Q L Q D T P E K T T Y I K Q N H Y Q E L N D I L N L G N F T E S T D G G K A I L K N H L D Q N P Q L Q W N T T E P S R T C K D P I E D I N S P E H I Q R R L S L Q L P I L H H A Y L P S I G G V D A S C V S P C V S P T A S P R H R H V P P S F R V M V S G L C-term S L P L Y S I L S A L T I L G M I M A S A F L F F N I K N S P Y M N N L I I L G G M L S Y A S I F L F G L S E K T F E T L C T V R T W I L T V G Y T T A F G A M F A K T W R V H A I F K K D Q K L L V I V G G M L L I D L C I L I C W Q A V D H M T I W L G I V Y A Y K G L L M L F G C F L A W E T R N V D S K Y I G M S V Y N V G I M C I I G A A V S F L T Q P N V Q F C I V A L V I I F C S T I T L C L V F V P K L I T L R T N P D A R R F A T Q N Q F
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Residue Table


GPCRdb(A)
GPCRdb(C)
GABAB2
TM5
5x49 5.49x49 L666
5x50 5.50x50 L667
5x53 5.53x53 F670
5x57 5.57x57 L674