Structure information

EP2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7CX3

SPECIES

Homo sapiens

RESOLUTION

2.800

PREFERRED CHAIN

R

REFERENCE

10.1126/SCIADV.ABF1268

PUBLICATION DATE

May 5, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
taprenepag S28 1.39x39 TM1 polar (hydrogen bond)
taprenepag S28 1.39x39 TM1 Van der Waals
taprenepag M31 1.42x42 TM1 hydrophobic
taprenepag M31 1.42x42 TM1 Van der Waals
taprenepag F32 1.43x43 TM1 Van der Waals
taprenepag F32 1.43x43 TM1 hydrophobic
taprenepag D78 2.50x50 TM2 Van der Waals
taprenepag G81 2.53x53 TM2 Van der Waals
taprenepag T82 2.54x54 TM2 polar (hydrogen bond)
taprenepag T82 2.54x54 TM2 Van der Waals
taprenepag T82 2.54x54 TM2 polar (hydrogen bond with backbone)
taprenepag I85 2.57x57 TM2 Van der Waals
taprenepag I85 2.57x57 TM2 hydrophobic
taprenepag S86 2.58x58 TM2 polar (hydrogen bond)
taprenepag S86 2.58x58 TM2 Van der Waals
taprenepag V89 2.61x61 TM2 Van der Waals
taprenepag V89 2.61x61 TM2 hydrophobic
taprenepag Y93 2.65x65 TM2 polar (hydrogen bond)
taprenepag M116 3.32x32 TM3 Van der Waals
taprenepag M116 3.32x32 TM3 hydrophobic
taprenepag F119 3.35x35 TM3 Van der Waals
taprenepag F119 3.35x35 TM3 hydrophobic
taprenepag T123 3.39x39 TM3 Van der Waals
taprenepag T185 ECL2 polar (hydrogen bond)
taprenepag W186 ECL2 aromatic (face-to-edge)
taprenepag W186 ECL2 Van der Waals
taprenepag L298 7.36x35 TM7 hydrophobic
taprenepag L298 7.36x35 TM7 Van der Waals
taprenepag R302 7.40x39 TM7 polar (charge-assisted hydrogen bond)
taprenepag S305 7.43x42 TM7 Van der Waals
taprenepag S308 7.46x46 TM7 Van der Waals
taprenepag I309 7.47x47 TM7 hydrophobic
taprenepag I309 7.47x47 TM7 Van der Waals

Ligands

taprenepag

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Residue Diagrams

L N G L V G A S F M V S S I A P S 1 T E L V F T D L L G T C L I S P V V L A 2 A F L M L M T A L S F F T M A F A F Y T 3 G L A V L P V I Y A V S L L F C S L P L 4 S F N C A L V S V I L L L L L T A Y L Q 5 A I M T I T F A V C S L P F T I F A Y M 6 W P D I I S N I S L F R L A Q L D W 7
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ICL1 W R G D V G C S A G R R S S L ICL1ECL1 Q T L V A L A P E ECL1ICL2 P Y F Y Q R R V ICL2ECL2 Y G Q Y V Q Y C P G T W C F I R H G R ECL2ICL3 P S L G S G R G G P G A R R R G E ICL3ECL3 N E T S S R K E K ECL3N-term M G N A S N D S Q S E D C E T R Q W L P P G E N-termC-term R I S L R T Q D A T Q T S C S T Q S D A S K Q A D L C-term S P A I S S V M F S A G V L G N L I A L A L L A R R S L F H V L V T E L V F T D L L G T C L I S P V V L A S Y A R N S R A C T Y F A F A M T F F S L A T M L M L F A M A L E R Y L S I G H S R S G G L A V L P V I Y A V S L L F C S L P L L D T A Y L Q L Y A T L L L L L I V S V L A C N F S V I L N L I R M H R R S R R S R C G R V S M A E E T D H L I L L A I M T I T F A V C S L P F T I F A Y M W D L Q A L R F L S I N S I I D P W V F A I L R P P M R S V L R L V L C C
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Residue Table


GPCRdb(A)
GPCRdb(A)
EP2 receptor
TM1
1x39 1.39x39 S28
1x42 1.42x42 M31
1x43 1.43x43 F32
TM2
2x50 2.50x50 D78
2x53 2.53x53 G81
2x54 2.54x54 T82
2x57 2.57x57 I85
2x58 2.58x58 S86
2x61 2.61x61 V89
2x65 2.65x65 Y93
TM3
3x32 3.32x32 M116
3x35 3.35x35 F119
3x39 3.39x39 T123
TM7
7x35 7.36x35 L298
7x39 7.40x39 R302
7x42 7.43x42 S305
7x46 7.46x46 S308
7x47 7.47x47 I309