Structure information

EP2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7CX3

SPECIES

Homo sapiens

RESOLUTION

2.800

PREFERRED CHAIN

R

PUBLICATION DATE

May 5, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Taprenepag S28 1.39x39 TM1 polar (charge-assisted hydrogen bond)
Taprenepag F32 1.43x43 TM1 hydrophobic
Taprenepag T82 2.54x54 TM2 polar (hydrogen bond)
Taprenepag T82 2.54x54 TM2 polar (hydrogen bond with backbone)
Taprenepag I85 2.57x56 TM2 hydrophobic
Taprenepag S86 2.58x57 TM2 polar (hydrogen bond)
Taprenepag V89 2.61x60 TM2 hydrophobic
Taprenepag Y93 2.65x64 TM2 polar (charge-assisted hydrogen bond)
Taprenepag M116 3.32x32 TM3 hydrophobic
Taprenepag F119 3.35x35 TM3 hydrophobic
Taprenepag T185 ECL2 polar (charge-assisted hydrogen bond)
Taprenepag W186 ECL2 aromatic (face-to-edge)
Taprenepag L298 7.36x35 TM7 hydrophobic
Taprenepag R302 7.40x39 TM7 polar (charge-charge)

Ligands

Taprenepag

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Residue Diagrams

L N G L V G A S F M V S S I A P S 1 T E L V F T D L L G T L C I S P V V L A S 2 A F L M L M T A L S F F T M A F A F Y T 3 G L A V L P V I Y A V S L L F C S L P L 4 S F N C A L V S V I L L L L L T A Y L Q 5 A I M T I T F A V C S L P F T I F A Y M 6 W P D I I S N I S L F R L A Q L D W 7
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ICL1 W R G D V G C S A G R R S S L ICL1ECL1 Q T L V A L A P E ECL1ICL2 P Y F Y Q R R V ICL2ECL2 Y G Q Y V Q Y C P G T W C F I R H G R ECL2ICL3 P S L G S G R G G P G A R R R G E ICL3ECL3 N E T S S R K E K ECL3N-term M G N A S N D S Q S E D C E T R Q W L P P G E N-termC-term R I S L R T Q D A T Q T S C S T Q S D A S K Q A D L C-term S P A I S S V M F S A G V L G N L I A L A L L A R R S L F H V L V T E L V F T D L L G T C L I S P V V L A S Y A R N S R A C T Y F A F A M T F F S L A T M L M L F A M A L E R Y L S I G H S R S G G L A V L P V I Y A V S L L F C S L P L L D T A Y L Q L Y A T L L L L L I V S V L A C N F S V I L N L I R M H R R S R R S R C G R V S M A E E T D H L I L L A I M T I T F A V C S L P F T I F A Y M W D L Q A L R F L S I N S I I D P W V F A I L R P P M R S V L R L V L C C
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Residue Table


GPCRdb(A)
GPCRdb(A)
EP2 receptor
TM1
1x39 1.39x39 S28
1x43 1.43x43 F32
TM2
2x54 2.54x54 T82
2x56 2.57x56 I85
2x57 2.58x57 S86
2x60 2.61x60 V89
2x64 2.65x64 Y93
TM3
3x32 3.32x32 M116
3x35 3.35x35 F119
TM7
7x35 7.36x35 L298
7x39 7.40x39 R302