Structure information

EP2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7CX4

SPECIES

Homo sapiens

RESOLUTION

2.900

PREFERRED CHAIN

R

PUBLICATION DATE

May 5, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Evatanepag S28 1.39x39 TM1 polar (charge-assisted hydrogen bond)
Evatanepag M31 1.42x42 TM1 polar (hydrogen bond)
Evatanepag T82 2.54x54 TM2 polar (hydrogen bond)
Evatanepag I85 2.57x56 TM2 hydrophobic
Evatanepag S86 2.58x57 TM2 polar (hydrogen bond)
Evatanepag Y93 2.65x64 TM2 polar (charge-assisted hydrogen bond)
Evatanepag M116 3.32x32 TM3 hydrophobic
Evatanepag W186 ECL2 aromatic (face-to-edge)
Evatanepag L298 7.36x35 TM7 hydrophobic
Evatanepag R302 7.40x39 TM7 polar (charge-charge)
Evatanepag I309 7.47x47 TM7 hydrophobic

Ligands

Evatanepag

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Residue Diagrams

L N G L V G A S F M V S S I A P S 1 T E L V F T D L L G T L C I S P V V L A S 2 A F L M L M T A L S F F T M A F A F Y T 3 G L A V L P V I Y A V S L L F C S L P L 4 S F N C A L V S V I L L L L L T A Y L Q 5 A I M T I T F A V C S L P F T I F A Y M 6 W P D I I S N I S L F R L A Q L D W 7
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ICL1 W R G D V G C S A G R R S S L ICL1ECL1 Q T L V A L A P E ECL1ICL2 P Y F Y Q R R V ICL2ECL2 Y G Q Y V Q Y C P G T W C F I R H G R ECL2ICL3 P S L G S G R G G P G A R R R G E ICL3ECL3 N E T S S R K E K ECL3N-term M G N A S N D S Q S E D C E T R Q W L P P G E N-termC-term R I S L R T Q D A T Q T S C S T Q S D A S K Q A D L C-term S P A I S S V M F S A G V L G N L I A L A L L A R R S L F H V L V T E L V F T D L L G T C L I S P V V L A S Y A R N S R A C T Y F A F A M T F F S L A T M L M L F A M A L E R Y L S I G H S R S G G L A V L P V I Y A V S L L F C S L P L L D T A Y L Q L Y A T L L L L L I V S V L A C N F S V I L N L I R M H R R S R R S R C G R V S M A E E T D H L I L L A I M T I T F A V C S L P F T I F A Y M W D L Q A L R F L S I N S I I D P W V F A I L R P P M R S V L R L V L C C
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Residue Table


GPCRdb(A)
GPCRdb(A)
EP2 receptor
TM1
1x39 1.39x39 S28
1x42 1.42x42 M31
TM2
2x54 2.54x54 T82
2x56 2.57x56 I85
2x57 2.58x57 S86
2x64 2.65x64 Y93
TM3
3x32 3.32x32 M116
TM7
7x35 7.36x35 L298
7x39 7.40x39 R302
7x47 7.47x47 I309