PDB
7CZ5
Resolution
2.6 Å
Released
Nov. 18, 2020
Receptor
GHRH
Class
B1
Species
Homo sapiens
Ligand
GHRH (Human)
Function
Agonist
Reference
10.1038/S41467-020-18945-0

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Ligand Amino Acid Generic Number Segment Interaction Type
GHRH (Human) L119 1.29x29 TM1 hydrophobic
GHRH (Human) F126 1.36x36 TM1 hydrophobic
GHRH (Human) V129 1.39x39 TM1 hydrophobic
GHRH (Human) Y133 1.43x43 TM1 aromatic (edge-to-face)
GHRH (Human) K182 2.67x67 TM2 polar (charge-assisted hydrogen bond)
GHRH (Human) F187 2.72x72 TM2 aromatic (face-to-edge)
GHRH (Human) F187 2.72x72 TM2 Van der Waals
GHRH (Human) D193 ECL1 Van der Waals
GHRH (Human) D193 ECL1 polar (hydrogen bond with backbone)
GHRH (Human) H194 ECL1 polar (hydrogen bond)
GHRH (Human) H194 ECL1 polar (hydrogen bond with backbone)
GHRH (Human) C195 ECL1 polar (hydrogen bond)
GHRH (Human) C195 ECL1 Van der Waals
GHRH (Human) H210 3.37x37 TM3 polar (hydrogen bond)
GHRH (Human) H210 3.37x37 TM3 Van der Waals
GHRH (Human) T213 3.40x40 TM3 Van der Waals
GHRH (Human) A271 ECL2 Van der Waals
GHRH (Human) A271 ECL2 polar (hydrogen bond with backbone)
GHRH (Human) D274 45.52x52 ECL2 polar (hydrogen bond with backbone)
GHRH (Human) D274 45.52x52 ECL2 polar (charge-assisted hydrogen bond)
GHRH (Human) D276 ECL2 polar (charge-assisted hydrogen bond)
GHRH (Human) W282 5.36x37 TM5 hydrophobic
GHRH (Human) W282 5.36x37 TM5 Van der Waals
GHRH (Human) I289 5.43x43 TM5 Van der Waals
GHRH (Human) I289 5.43x43 TM5 hydrophobic
GHRH (Human) N346 ECL3 polar (hydrogen bond)
GHRH (Human) D350 ECL3 Van der Waals
GHRH (Human) L354 7.35x34 TM7 hydrophobic
GHRH (Human) L354 7.35x34 TM7 Van der Waals
GHRH (Human) R357 7.38x37 TM7 Van der Waals
GHRH (Human) L358 7.39x38 TM7 Van der Waals
GHRH (Human) E361 7.42x41 TM7 Van der Waals
GHRH (Human) L362 7.43x42 TM7 hydrophobic
GHRH (Human) L362 7.43x42 TM7 Van der Waals

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ICL1 R R L H ICL1ECL1 H S D D T D H C S F S ECL1ICL2 T S P S S ICL2ECL2 D I A C W D L D D T S P Y ECL2ICL3 E P A Q G S L ICL3ECL3 P D N A ECL3N-term M D R R M W G A H V F C V L S P L P T V L G H M H P E C D F I T Q L R E D E S A C L Q A A E E M P N T T L G C P A T W D G L L C W P T A G S G E W V T L P C P D F F S H F S S E S G A V K R D C T I T G W S E P F P P Y P V A C P V P N-termC-term A K W T T P S R S A A K V L T S M C C-term L E L L A E E E S Y F S T V K I I Y T V G H S I S I V A L F V A I T I L V A L C P R N Y V H T Q L F T T F I L K A G A V F L K D A A L F T V L C K V S V A A S H F A T M T N F S W L L A E A V Y L N C L L A S R R A F W W L V L A G W G L P V L F T G T W V S C K L A F E W W I I K G P I V L S V G V N F G L F L N I I R I L V R K L H T Q S Q Y W R L S K S T L F L I P L F G I H Y I I F N F L G L G I R L P L E L G L G S F Q G F I V A I L Y C F L N Q E I S R H D P A W R V R T E K W H G E L L P T R
Helix box plot — Download: PNG | SVG F L A V I S I S H G V T Y I I K V T S F 1 T Q L F T T F I L K A G A V F L K D A A 2 A L L W S F N T M T A F H S A A V S V K 3 A F W W L V L G A W G L P V L F T G T W V 4 F L G F N V G V S L V I P G K I I W W 5 L F L I P L F G I H Y I I F N F L 6 I A V I F G Q F S G L G L E L P L R I 7

GPCRdb(A)
GPCRdb(B)
GHRH receptor
TM1
1x25 1.29x29 L119
1x32 1.36x36 F126
1x35 1.39x39 V129
1x39 1.43x43 Y133
TM2
2x60 2.67x67 K182
2x65 2.72x72 F187
TM3
3x33 3.37x37 H210
3x36 3.40x40 T213
ECL2
45x52 45.52x52 D274
TM5
5x41 5.36x37 W282
5x47 5.43x43 I289
TM7
7x30 7.35x34 L354
7x33 7.38x37 R357
7x34 7.39x38 L358
7x37 7.42x41 E361
7x38 7.43x42 L362