Structure information

GLP-2 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

7D68

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

R

REFERENCE

10.1038/S41422-020-00442-0

PUBLICATION DATE

Dec. 16, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
glucagon F165 N-term hydrophobic
glucagon N168 1.29x29 TM1 polar (hydrogen bond)
glucagon R171 1.32x32 TM1 Van der Waals
glucagon Y172 1.33x33 TM1 Van der Waals
glucagon Y172 1.33x33 TM1 hydrophobic
glucagon L175 1.36x36 TM1 Van der Waals
glucagon L175 1.36x36 TM1 hydrophobic
glucagon L178 1.39x39 TM1 Van der Waals
glucagon L178 1.39x39 TM1 hydrophobic
glucagon Q179 1.40x40 TM1 Van der Waals
glucagon Y182 1.43x43 TM1 aromatic (edge-to-face)
glucagon Y182 1.43x43 TM1 Van der Waals
glucagon Y186 1.47x47 TM1 polar (hydrogen bond)
glucagon Y186 1.47x47 TM1 Van der Waals
glucagon V228 2.64x64 TM2 hydrophobic
glucagon V228 2.64x64 TM2 Van der Waals
glucagon K231 2.67x67 TM2 polar (charge-assisted hydrogen bond)
glucagon F235 2.71x71 TM2 hydrophobic
glucagon F235 2.71x71 TM2 Van der Waals
glucagon Y239 2.75x75 TM2 hydrophobic
glucagon Y239 2.75x75 TM2 Van der Waals
glucagon R242 ECL1 polar (charge-assisted hydrogen bond)
glucagon D244 ECL1 polar (charge-assisted hydrogen bond)
glucagon E246 ECL1 Van der Waals
glucagon N247 ECL1 Van der Waals
glucagon W249 ECL1 Van der Waals
glucagon W249 ECL1 aromatic (face-to-edge)
glucagon H268 3.37x37 TM3 polar (hydrogen bond)
glucagon H268 3.37x37 TM3 aromatic (face-to-edge)
glucagon V271 3.40x40 TM3 Van der Waals
glucagon V271 3.40x40 TM3 hydrophobic
glucagon T332 45.52x52 ECL2 polar (hydrogen bond)
glucagon T333 ECL2 Van der Waals
glucagon N334 ECL2 Van der Waals
glucagon W340 5.36x37 TM5 hydrophobic
glucagon W340 5.36x37 TM5 Van der Waals
glucagon R344 5.40x40 TM5 Van der Waals
glucagon K414 7.35x34 TM7 polar (charge-assisted hydrogen bond)
glucagon R417 7.38x37 TM7 Van der Waals
glucagon L418 7.39x38 TM7 hydrophobic
glucagon L418 7.39x38 TM7 Van der Waals
glucagon Q421 7.42x41 TM7 Van der Waals
glucagon L422 7.43x42 TM7 Van der Waals
glucagon L422 7.43x42 TM7 hydrophobic

Ligands

glucagon

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Residue Diagrams

F L S I L S F S Y G V T Y M L Q L T S L 1 M N L F A S F I L R T L A V L V K D V V 2 V L L W L Y N A G V F Y H L L V Q V S R 3 L W P R Y L L G L W A F P V L F V V P W G 4 F I F F N V T V C L M M P G R I I W W I K 5 L V L I P L L G V H E I L F S F 6 L A V L F G H F S S L T L Q I F L R I 7
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ICL1 R K L H ICL1ECL1 S K R P D N E N G W M S Y L S E M S ECL1ICL2 T V L P E R R ICL2ECL2 N T G C W T T N G N K ECL2ICL3 A H Q M ICL3ECL3 I T D D Q V E ECL3N-term M K L G S S R A G P G R G S A G L L P G V H E L P M G I P A P W G T S P L S F H R K C S L W A P G R P F L T L V L L V S I K Q V T G S L L E E T T R K W A Q Y K Q A C L R D L L K E P S G I F C N G T F D Q Y V C W P H S S P G N V S V P C P S Y L P W W S E E S S G R A Y R H C L A Q G T W Q T I E N A T D I W Q D D S E C S E N H S F N-termC-term V L G K D F R F L G K C P K K L S E G D G A E K L R K L Q P S L N S G R L L H L A M R G L G E L G A Q P Q Q D H A R W P R G S S L S E C S E G D V T M A N T M E E I L E E S E I C-term K Q N V D R Y A L L S T L Q L M Y T V G Y S F S L I S L F L A L T L L L F L C T R N Y I H M N L F A S F I L R T L A V L V K D V V F Y N S Y T S C R S V Q V L L H Y F V G A N Y L W L L V E G L Y L H T L L E P L W P R Y L L L G W A F P V L F V V P W G F A R A H L E K I W W I I R G P M M L C V T V N F F I F L K I L K L L I S K L K C F R D Y K Y R L A K S T L V L I P L L G V H E I L F S F G F A K L I R L F I Q L T L S S F H G F L V A L Q Y G F A N G E L R K F L L G C R V K A E Y W V R A R H S A C
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Residue Table


GPCRdb(A)
GPCRdb(B)
GLP-2 receptor
TM1
1x25 1.29x29 N168
1x28 1.32x32 R171
1x29 1.33x33 Y172
1x32 1.36x36 L175
1x35 1.39x39 L178
1x36 1.40x40 Q179
1x39 1.43x43 Y182
1x43 1.47x47 Y186
TM2
2x57 2.64x64 V228
2x60 2.67x67 K231
2x64 2.71x71 F235
2x68 2.75x75 Y239
TM3
3x33 3.37x37 H268
3x36 3.40x40 V271
ECL2
45x52 45.52x52 T332
TM5
5x41 5.36x37 W340
5x44 5.40x40 R344
TM7
7x30 7.35x34 K414
7x33 7.38x37 R417
7x34 7.39x38 L418
7x37 7.42x41 Q421
7x38 7.43x42 L422