Structure information

EP4 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7D7M

SPECIES

Homo sapiens

RESOLUTION

3.300

PREFERRED CHAIN

A

REFERENCE

PUBLICATION DATE

Nov. 18, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
PGE<sub>2</sub> M27 1.42x42 TM1 polar (hydrogen bond)
PGE<sub>2</sub> T69 2.54x54 TM2 polar (hydrogen bond with backbone)
PGE<sub>2</sub> V72 2.57x56 TM2 polar (hydrogen bond with backbone)
PGE<sub>2</sub> T76 2.61x60 TM2 polar (hydrogen bond)
PGE<sub>2</sub> Y80 2.65x64 TM2 polar (charge-assisted hydrogen bond)
PGE<sub>2</sub> T168 ECL2 polar (charge-assisted hydrogen bond)
PGE<sub>2</sub> W169 ECL2 hydrophobic
PGE<sub>2</sub> L312 7.36x35 TM7 hydrophobic
PGE<sub>2</sub> I315 7.39x38 TM7 hydrophobic
PGE<sub>2</sub> R316 7.40x39 TM7 polar (charge-charge)

Ligands

PGE<sub>2</sub>

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Residue Diagrams

L N G V V G F I F M V A P I T V P S N 1 C G L A V T D L L G T L L V S P V T I A T 2 A C I I S L G S L S F F L L I F T S Y E 3 A G L T L F A V Y A S N V L F C A L P N 4 N C L V T A L I L F S S F G A Y M Y S Y 5 I A T S L V V L I C S I P L V V R V F V 6 W P D L I P N V S A I R I A Q L D P N 7
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ICL1 R K E Q K E ICL1ECL1 G Q W P G ECL1ICL2 A Y F Y S H Y V ICL2ECL2 L G S S R L Q Y P D T W C F I D W T T N ECL2ICL3 S L G T E Q H H A A A A A S V A S R G H P A A S P A L P R L S D F R R R R S F ICL3ECL3 Q P S L E R E V S K ECL3N-term M S T P G V N S S A S L S P D R L N-termC-term L F C R I G G S R R E R S G Q H C S D S Q R T S S A M S G H S R S F I S R E L K E I S S T S Q T L L P D L S L P D L S E N G L G G R N L L P G V P G M G L A Q E D T T S L R T L R I S E T S D S S Q G Q D S E S V L L V D E A G G S G R A G P A P K G S S L Q V T F P S E T L N L S E K C I C-term N S P V T I P A V M F I F G V V G N L V A I V V L C K S T T F Y T L V C G L A V T D L L G T L L V S P V T I A T Y M K G Q P L C E Y S T F I L L F F S L S G L S I I C A M S V E R Y L A I N H D K R L A G L T L F A V Y A S N V L F C A L P N M G V T A H A A Y S Y M Y A G F S S F L I L A T V L C N V L V C G A L L R M H R Q F M R R T R R I A G A E I Q M V I L L I A T S L V V L I C S I P L V V R V F V N Q L Y N P D L Q A I R I A S V N P I L D P W I Y I L L R K T A I E V L S K K I K C
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Residue Table


GPCRdb(A)
GPCRdb(A)
EP4 receptor
TM1
1x42 1.42x42 M27
TM2
2x54 2.54x54 T69
2x56 2.57x56 V72
2x60 2.61x60 T76
2x64 2.65x64 Y80
TM7
7x35 7.36x35 L312
7x38 7.39x38 I315
7x39 7.40x39 R316