PDB
7DHI
Resolution
3.3 Å
Released
Dec. 16, 2020
Receptor
β2
Class
A
Species
Homo sapiens
Ligand
Function
levosalbutamol
Agonist (partial)
Reference
10.1093/NSR/NWAA284

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Ligand Amino Acid Generic Number Segment Interaction Type
levosalbutamol W109 3.28x28 TM3 hydrophobic
levosalbutamol T110 3.29x29 TM3 Van der Waals
levosalbutamol D113 3.32x32 TM3 polar (charge-charge)
levosalbutamol D113 3.32x32 TM3 polar (hydrogen bond)
levosalbutamol V114 3.33x33 TM3 hydrophobic
levosalbutamol V117 3.36x36 TM3 hydrophobic
levosalbutamol F193 45.52x52 ECL2 aromatic (pi-cation)
levosalbutamol F193 45.52x52 ECL2 hydrophobic
levosalbutamol S203 5.42x43 TM5 polar (hydrogen bond)
levosalbutamol S204 5.43x44 TM5 Van der Waals
levosalbutamol S207 5.46x461 TM5 polar (hydrogen bond)
levosalbutamol F289 6.51x51 TM6 hydrophobic
levosalbutamol F289 6.51x51 TM6 aromatic (edge-to-face)
levosalbutamol F290 6.52x52 TM6 aromatic (edge-to-face)
levosalbutamol N293 6.55x55 TM6 Van der Waals
levosalbutamol N312 7.39x38 TM7 polar (hydrogen bond)
levosalbutamol Y316 7.43x42 TM7 Van der Waals

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ICL1 E R L Q ICL1ECL1 M W T F ECL1ICL2 P F K Y Q S L L ICL2ECL2 W Y R A T H Q E A I N C Y A N E T C C D F F T ECL2ICL3 G R F H V Q N L S Q V E Q D G R T G H G L R R S ICL3ECL3 D N L I ECL3N-term M G Q P G N G S A F L L A P N G S H A P D H D V T N-termC-term L R R S S L K A Y G N G Y S S N G N T G E Q S G Y H V E Q E K E N K L L C E D L P G T E D F V G H Q G T V P S D N I D S Q G R N C S T N D S L L C-term Q E R D E V W V V G M G I V M S L I V L A I V F G N V L V I T A I A K F T V T N Y F I T S L A C A D L V M G L A V V P F G A A H I L M K G N F W C E F W T S I D V L C V T A S I E T L C V I A V D R Y F A I T S T K N K A R V I I L M V W I V S G L T S F L P I Q M H N Q A Y A I A S S I V S F Y V P L V I M V F V Y S R V F Q E A K R Q L Q K I D K S E S K F C L K E H K A L K T L G I I M G T F T L C W L P F F I V N I V H V I Q R K E V Y I L L N W I G Y V N S G F N P L I Y C R S P D F Q E F R I A L L C
Helix box plot — Download: PNG | SVG V N G F V I A L V I L S M V I G M G V V 1 T S L A C A D L V M G A L V V P F G A A H 2 V C L T E I S A T V C L V D I S T W F E 3 A R V I I L M V W I V S G L T S F L P I 4 Y V F V M I V L P V Y F S V I S S A I A Y 5 G I I M G T F T L C W L P F F I V N I V 6 L P N F G S N V Y G I W N L L I Y V E 7

GPCRdb(A)
GPCRdb(A)
β2-adrenoceptor
TM3
3x28 3.28x28 W109
3x29 3.29x29 T110
3x32 3.32x32 D113
3x33 3.33x33 V114
3x36 3.36x36 V117
ECL2
45x52 45.52x52 F193
TM5
5x43 5.42x43 S203
5x44 5.43x44 S204
5x461 5.46x461 S207
TM6
6x51 6.51x51 F289
6x52 6.52x52 F290
6x55 6.55x55 N293
TM7
7x38 7.39x38 N312
7x42 7.43x42 Y316