Structure information

α2A-adrenoceptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7EJ8

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

R

REFERENCE

10.1126/SCIADV.ABJ5347

PUBLICATION DATE

April 13, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
brimonidine D128 3.32x32 TM3 polar (charge-assisted hydrogen bond)
brimonidine V129 3.33x33 TM3 hydrophobic
brimonidine V129 3.33x33 TM3 Van der Waals
brimonidine S215 5.42x43 TM5 Van der Waals
brimonidine S219 5.46x461 TM5 Van der Waals
brimonidine W402 6.48x48 TM6 Van der Waals
brimonidine W402 6.48x48 TM6 hydrophobic
brimonidine F405 6.51x51 TM6 hydrophobic
brimonidine F405 6.51x51 TM6 Van der Waals
brimonidine F406 6.52x52 TM6 Van der Waals
brimonidine Y409 6.55x55 TM6 Van der Waals
brimonidine Y409 6.55x55 TM6 aromatic (edge-to-face)
brimonidine F427 7.39x38 TM7 hydrophobic
brimonidine F427 7.39x38 TM7 Van der Waals
brimonidine Y431 7.43x42 TM7 polar (hydrogen bond)

Ligands

brimonidine

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Residue Diagrams

V N G F V T L L M L L G A L C V L T L T 1 V S L A S A D I L V A L T V I P F S L A N 2 A C L H V I S S T C F L V D L A L Y I E 3 I K A I I I T V W V I S A V I S F P P L 4 Y V L I M I L C P A F F S G I C S S I V Y 5 A V V I G V F V V C W F P F F F T Y T L 6 V P N L S S N C Y G F W F F F K F L T 7
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ICL1 R A L K ICL1ECL1 Y W Y F ECL1ICL2 A I E Y N L K R ICL2ECL2 S I E K K G G G G G P Q P A E P R C E I N D ECL2ICL3 R G P D A V A A P P G G T E R R P N G L G P E R S A G P G G A E A E P L P T Q L N G A P G E P A P A G P R D T D A L D L E E S S S S D H A E R P P G P R R P E R G P R G K G K A R A S Q V K P G D S L P R R G P G A T G I G T P A A G P G E E R V G A A K A S R W ICL3ECL3 C S V ECL3N-term M F R Q E Q P L A E G S F A P M G S L Q P D A G N A S W N G T E A P G G G A R A T P Y S L N-termC-term G D R K R I V C-term Q V T L T L V C L A G L L M L L T V F G N V L V I I A V F T S A P Q N L F L V S L A S A D I L V A T L V I P F S L A N E V M G G K A W C E I Y L A L D V L F C T S S I V H L C A I S L D R Y W S I T Q T P R R I K A I I I T V W V I S A V I S F P P L I Q K W Y V I S S C I G S F F A P C L I M I L V Y V R I Y Q I A K R R T R V P P S R R G R Q N R E K R F T F V L A V V I G V F V V C W F P F F F T Y T L T A V G P R T L F K F F F W F G Y C N S S L N P V I Y T I F N H D F K K F R R A I L C R
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Residue Table


GPCRdb(A)
GPCRdb(A)
α2A-adrenoceptor
TM3
3x32 3.32x32 D128
3x33 3.33x33 V129
TM5
5x43 5.42x43 S215
5x461 5.46x461 S219
TM6
6x48 6.48x48 W402
6x51 6.51x51 F405
6x52 6.52x52 F406
6x55 6.55x55 Y409
TM7
7x38 7.39x38 F427
7x42 7.43x42 Y431