PDB
7EUO
Resolution
2.9 Å
Released
May 25, 2022
Receptor
FPR1
Class
A
Species
Homo sapiens
Ligand
Function
fMet-Leu-Phe
Agonist
Reference
10.1038/S41467-022-32822-Y

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Ligand Amino Acid Generic Number Segment Interaction Type
fMet-Leu-Phe F81 2.60x60 TM2 hydrophobic
fMet-Leu-Phe F102 3.29x29 TM3 hydrophobic
fMet-Leu-Phe V105 3.32x32 TM3 hydrophobic
fMet-Leu-Phe D106 3.33x33 TM3 polar (hydrogen bond)
fMet-Leu-Phe L109 3.36x36 TM3 hydrophobic
fMet-Leu-Phe F110 3.37x37 TM3 hydrophobic
fMet-Leu-Phe V113 3.40x40 TM3 hydrophobic
fMet-Leu-Phe L198 5.35x36 TM5 Van der Waals
fMet-Leu-Phe R201 5.38x39 TM5 polar (hydrogen bond)
fMet-Leu-Phe R205 5.42x43 TM5 polar (hydrogen bond)
fMet-Leu-Phe R205 5.42x43 TM5 hydrophobic
fMet-Leu-Phe G209 5.46x461 TM5 Van der Waals
fMet-Leu-Phe W254 6.48x48 TM6 hydrophobic
fMet-Leu-Phe Y257 6.51x51 TM6 polar (hydrogen bond)
fMet-Leu-Phe Q258 6.52x52 TM6 Van der Waals
fMet-Leu-Phe A264 6.58x58 TM6 hydrophobic
fMet-Leu-Phe I268 ECL3 hydrophobic
fMet-Leu-Phe V283 7.35x34 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 T H ICL1ECL1 G H W P F ECL1ICL2 P V W T Q N H R ICL2ECL2 T T V P G K T G T V A C T F N F S P W T N ECL2ICL3 L I K S ICL3ECL3 I R E L L Q G M ECL3N-term M E T N S S L P T N I S G G T P A V N-termC-term P A S L E R A L T E D S T Q T S D T A T N S T L P S A E V E L Q A K C-term S A G Y L F L D I I T Y L V F A V T F V L G V L G N G L V I W V A G F R M T V T T I S Y L N L A V A D F C F T S T L P F F M V R K A M G G W F L C K F V F T I V D I N L F G S V F L I A L I A L D R C V C V L H T V S L A K K V I I G P W V M A L L L T L P V I I R V D P K E R I N V A V A M L T V R G I I R F I I G F S A P M S I V A V S Y G L I A T K I H K Q G S R P L R V L S F V A A A F F L C W S P Y Q V V A L I A T V R Y K E I G I A V D V T S A L A F F N S C L N P M L Y V F M G Q D L I H F R E R A L
Helix box plot — Download: PNG | SVG G N G L V G L V F T V A F V L Y T I I D 1 L N L A V A D F C F T S T L P F F M V R 2 L A I L F V S G F L N I D V I T F V F K 3 A K K V I I G P W V M A L L L T L P V 4 Y S V A V I S M P A S F G I I F R I I G R 5 S F V A A A F F L C W S P Y Q V V A L I 6 M P N L C S N F F A L A S T V D V A I 7

GPCRdb(A)
GPCRdb(A)
FPR1
TM2
2x60 2.60x60 F81
TM3
3x29 3.29x29 F102
3x32 3.32x32 V105
3x33 3.33x33 D106
3x36 3.36x36 L109
3x37 3.37x37 F110
3x40 3.40x40 V113
TM5
5x36 5.35x36 L198
5x39 5.38x39 R201
5x43 5.42x43 R205
5x461 5.46x461 G209
TM6
6x48 6.48x48 W254
6x51 6.51x51 Y257
6x52 6.52x52 Q258
6x58 6.58x58 A264
TM7
7x34 7.35x34 V283