Structure information

S1P1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7EVZ

SPECIES

Homo sapiens

RESOLUTION

3.070

PREFERRED CHAIN

D

REFERENCE

10.1038/S41422-021-00566-X

PUBLICATION DATE

Sept. 29, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
cenerimod K34 polar (charge-assisted hydrogen bond)
cenerimod M124 3.32x32 TM3 Van der Waals
cenerimod F125 3.33x33 TM3 hydrophobic
cenerimod F125 3.33x33 TM3 Van der Waals
cenerimod L128 3.36x36 TM3 hydrophobic
cenerimod L128 3.36x36 TM3 Van der Waals
cenerimod S129 3.37x37 TM3 Van der Waals
cenerimod V132 3.40x40 TM3 Van der Waals
cenerimod V132 3.40x40 TM3 hydrophobic
cenerimod V194 ECL2 hydrophobic
cenerimod V194 ECL2 Van der Waals
cenerimod L195 ECL2 hydrophobic
cenerimod C206 5.43x43 TM5 Van der Waals
cenerimod F210 5.47x47 TM5 hydrophobic
cenerimod W269 6.48x48 TM6 aromatic (edge-to-face)
cenerimod W269 6.48x48 TM6 Van der Waals
cenerimod L272 6.51x51 TM6 Van der Waals
cenerimod L272 6.51x51 TM6 hydrophobic
cenerimod L276 6.55x55 TM6 Van der Waals
cenerimod L276 6.55x55 TM6 hydrophobic
cenerimod L297 7.39x38 TM7 hydrophobic

Ligands

cenerimod

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Residue Diagrams

I N E L I I F C C I L I F V V S T L K I 1 G N L A L S D L L A G V A Y T A N L L L 2 A L L S F V S A S L A V F M S G E R L F 3 L F L L I S A C W V I S L I L G G L P I 4 Y L I V I S L L L L T F V T T C F L I Y 5 I I V L S V F I A C W A P L F I L L L L 6 I P N T G S N L V A L V L F Y E A R F 7
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ICL1 K K F H ICL1ECL1 G A T T Y K L ECL1ICL2 M K L H N G S ICL2ECL2 W N C I S A L S S C S T V L P L Y ECL2ICL3 F R K N I S K A ICL3ECL3 K V K T C ECL3N-term M G P T S V P L V K A H R S S V S D Y V N Y D I I V R H Y N Y T G K L N I S A D K N-termC-term C C K C P S G D S A G K F K R P I I A G M E F S R S K S D N S S H P Q K D E G D N P E T I M S S G N V N S S S C-term E N S I K L T S V V F I L I C C F I I L E N I F V L L T I W K T R P M Y Y F I G N L A L S D L L A G V A Y T A N L L L S T P A Q W F L R E G S M F V A L S A S V F S L L A I A I E R Y I T M L K N N F R L F L L I S A C W V I S L I L G G L P I M G H K H Y I L F C T T V F T L L L L S I V I L Y C R I Y S L V R T R S R R L T S R S S E K S L A L L K T V I I V L S V F I A C W A P L F I L L L L D V G C D I L F R A E Y F L V L A V L N S G T N P I I Y T L T N K E F I R M R R A I M S
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Residue Table


GPCRdb(A)
GPCRdb(A)
S1P1 receptor
TM3
3x32 3.32x32 M124
3x33 3.33x33 F125
3x36 3.36x36 L128
3x37 3.37x37 S129
3x40 3.40x40 V132
TM5
5x43 5.43x43 C206
5x47 5.47x47 F210
TM6
6x48 6.48x48 W269
6x51 6.51x51 L272
6x55 6.55x55 L276
TM7
7x38 7.39x38 L297