Structure information

S1P5 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7EW1

SPECIES

Homo sapiens

RESOLUTION

3.400

PREFERRED CHAIN

A

PUBLICATION DATE

Sept. 29, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
siponimod K24 N-term polar (charge-charge)
siponimod N92 2.60x60 TM2 polar (charge-assisted hydrogen bond)
siponimod W108 3.25x25 TM3 polar (charge-assisted hydrogen bond)
siponimod F116 3.33x33 TM3 hydrophobic
siponimod L119 3.36x36 TM3 hydrophobic
siponimod V123 3.40x40 TM3 hydrophobic
siponimod C197 5.43x43 TM5 polar (hydrogen bond)
siponimod L267 6.51x51 TM6 hydrophobic
siponimod L292 7.39x38 TM7 hydrophobic

Ligands

siponimod

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Residue Diagrams

L N E L V I F A C V A L C V V A D A R 1 G S L T L S D L L A G A A Y A A N I L L 2 A L L S L V S A T L A V F V G G E R A F 3 T L A M A A A A W G V S L L L G L L P A 4 Y L A C I A A L I G V F A L V C F L V Y 5 S V V L L A F V A C W G P L F L L L L L 6 I P N L L S N A M A L G L F P D A Q L 7
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ICL1 P R F H ICL1ECL1 G P L T L K L ECL1ICL2 R G P A P V S ICL2ECL2 W N C L G R L D A C S T V L P L Y ECL2ICL3 T T S T ICL3ECL3 P A R T C ECL3N-term M E S G L L R P A P V S E V I V L H Y N Y T G K L R G A R Y Q P G A G L N-termC-term C G R H S C G R D P S G S Q Q S A S A A E A S G G L R R C L P P G L D G S F S G S E R S S P Q R D G L D T S G S T G S P G A P T A A R T L V S E P A A D C-term R A D A V V C L A V C A F I V L E N L A V L L V L G R H A P M F L L L G S L T L S D L L A G A A Y A A N I L L S S P A L W F A R E G G V F V A L T A S V L S L L A I A L E R S L T M A R S R G R T L A M A A A A W G V S L L L G L L P A L G A K A Y V L F C V L A F V G I L A A I C A L Y A R I Y C Q V R A N A R R L P A R P G T A G R A R R K P R S L A L L R T L S V V L L A F V A C W G P L F L L L L L D V A C P V L L Q A D P F L G L A M A N S L L N P I I Y T L T N R D L L R L R H A L V C
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Residue Table


GPCRdb(A)
GPCRdb(A)
S1P5 receptor
TM2
2x60 2.60x60 N92
TM3
3x25 3.25x25 W108
3x33 3.33x33 F116
3x36 3.36x36 L119
3x40 3.40x40 V123
TM5
5x43 5.43x43 C197
TM6
6x51 6.51x51 L267
TM7
7x38 7.39x38 L292