Structure information

S1P1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7EW7

SPECIES

Homo sapiens

RESOLUTION

3.270

PREFERRED CHAIN

D

REFERENCE

10.1038/S41422-021-00566-X

PUBLICATION DATE

Sept. 29, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
SEW2871 N101 2.60x60 TM2 polar (hydrogen bond)
SEW2871 E121 3.29x29 TM3 polar (charge-assisted hydrogen bond)
SEW2871 M124 3.32x32 TM3 Van der Waals
SEW2871 F125 3.33x33 TM3 aromatic (face-to-face)
SEW2871 F125 3.33x33 TM3 Van der Waals
SEW2871 L128 3.36x36 TM3 Van der Waals
SEW2871 L128 3.36x36 TM3 hydrophobic
SEW2871 S129 3.37x37 TM3 Van der Waals
SEW2871 V132 3.40x40 TM3 hydrophobic
SEW2871 V132 3.40x40 TM3 Van der Waals
SEW2871 L195 ECL2 hydrophobic
SEW2871 L195 ECL2 Van der Waals
SEW2871 F210 5.47x47 TM5 hydrophobic
SEW2871 F210 5.47x47 TM5 Van der Waals
SEW2871 W269 6.48x48 TM6 hydrophobic
SEW2871 W269 6.48x48 TM6 Van der Waals
SEW2871 L276 6.55x55 TM6 Van der Waals
SEW2871 L297 7.39x38 TM7 Van der Waals
SEW2871 L297 7.39x38 TM7 hydrophobic

Ligands

SEW2871

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Residue Diagrams

I N E L I I F C C I L I F V V S T L K I 1 G N L A L S D L L A G V A Y T A N L L L 2 A L L S F V S A S L A V F M S G E R L F 3 L F L L I S A C W V I S L I L G G L P I 4 Y L I V I S L L L L T F V T T C F L I Y 5 I I V L S V F I A C W A P L F I L L L L 6 I P N T G S N L V A L V L F Y E A R F 7
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ICL1 K K F H ICL1ECL1 G A T T Y K L ECL1ICL2 M K L H N G S ICL2ECL2 W N C I S A L S S C S T V L P L Y ECL2ICL3 F R K N I S K A ICL3ECL3 K V K T C ECL3N-term M G P T S V P L V K A H R S S V S D Y V N Y D I I V R H Y N Y T G K L N I S A D K N-termC-term C C K C P S G D S A G K F K R P I I A G M E F S R S K S D N S S H P Q K D E G D N P E T I M S S G N V N S S S C-term E N S I K L T S V V F I L I C C F I I L E N I F V L L T I W K T R P M Y Y F I G N L A L S D L L A G V A Y T A N L L L S T P A Q W F L R E G S M F V A L S A S V F S L L A I A I E R Y I T M L K N N F R L F L L I S A C W V I S L I L G G L P I M G H K H Y I L F C T T V F T L L L L S I V I L Y C R I Y S L V R T R S R R L T S R S S E K S L A L L K T V I I V L S V F I A C W A P L F I L L L L D V G C D I L F R A E Y F L V L A V L N S G T N P I I Y T L T N K E F I R M R R A I M S
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Residue Table


GPCRdb(A)
GPCRdb(A)
S1P1 receptor
TM2
2x60 2.60x60 N101
TM3
3x29 3.29x29 E121
3x32 3.32x32 M124
3x33 3.33x33 F125
3x36 3.36x36 L128
3x37 3.37x37 S129
3x40 3.40x40 V132
TM5
5x47 5.47x47 F210
TM6
6x48 6.48x48 W269
6x55 6.55x55 L276
TM7
7x38 7.39x38 L297