Structure information

5-HT1F receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7EXD

SPECIES

Homo sapiens

RESOLUTION

3.400

PREFERRED CHAIN

R

PUBLICATION DATE

Aug. 4, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
lasmiditan D103 3.32x32 TM3 polar (charge-charge)
lasmiditan I104 3.33x33 TM3 hydrophobic
lasmiditan C107 3.36x36 TM3 polar (hydrogen bond)
lasmiditan I174 45.52x52 ECL2 hydrophobic
lasmiditan H176 ECL2 polar (hydrogen bond with backbone)
lasmiditan F309 6.51x51 TM6 hydrophobic
lasmiditan F310 6.52x52 TM6 hydrophobic
lasmiditan E313 6.55x55 TM6 polar (charge-assisted hydrogen bond)
lasmiditan N317 6.59x59 TM6 polar (hydrogen bond)

Ligands

lasmiditan

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Residue Diagrams

S N I T T T M L A L G S L T L S V L I K 1 C S L A V T D F L V A L V V M P F S I V Y 2 A S L H L I S C T C C T I D V S L W I D 3 A G I M I T I V W I I S V F I S M P P L 4 Y L I L I L A L P I Y F A G F T S Y I T S 5 G L I L G A F V I C W L P F F V K E L V 6 L P N I L S N L Y G L W A L F N S M E 7
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ICL1 R K L H ICL1ECL1 S W I M ECL1ICL2 A V E Y A R K R ICL2ECL2 Q G T S R D D E C I I K H D ECL2ICL3 I A K E E V N G Q V L L E S G E K S T K S V S T S Y V L E K S L S D P S T D F D K I H S T V R S L R S E F K H E K S W R R Q ICL3ECL3 D K C K I ECL3N-term M D F L N S S D Q N L T S E E L L N R N-termC-term V R C R C C-term M P S K I L V S L T L S G L A L M T T T I N S L V I A A I I V T H P A N Y L I C S L A V T D F L V A V L V M P F S I V Y I V R E G Q V V C D I W L S V D I T C C T C S I L H L S A I A L D R Y R A I T D T P K H A G I M I T I V W I I S V F I S M P P L F W R H H I V S T I Y S T F G A F Y I P L A L I L I L Y Y K I Y R A A K T L Y H K R Q A S R K I S G T R E R K A A T T L G L I L G A F V I C W L P F F V K E L V V N V C S E E M S N F L A W L G Y L N S L I N P L I Y T I F N E D F Q K F K K A L
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Residue Table


GPCRdb(A)
GPCRdb(A)
5-HT1F receptor
TM3
3x32 3.32x32 D103
3x33 3.33x33 I104
3x36 3.36x36 C107
ECL2
45x52 45.52x52 I174
TM6
6x51 6.51x51 F309
6x52 6.52x52 F310
6x55 6.55x55 E313
6x59 6.59x59 N317