Structure information

PTH2 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

7F16

SPECIES

Homo sapiens

RESOLUTION

2.800

PREFERRED CHAIN

R

PUBLICATION DATE

Aug. 18, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
TIP39 I32 N-term polar (hydrogen bond with backbone)
TIP39 I34 N-term hydrophobic
TIP39 I38 N-term hydrophobic
TIP39 D92 N-term polar (charge-charge)
TIP39 D92 N-term polar (charge-assisted hydrogen bond)
TIP39 D92 N-term polar (charge-charge)
TIP39 F93 N-term hydrophobic
TIP39 M112 N-term polar (hydrogen bond)
TIP39 Q130 1.25x25 TM1 polar (hydrogen bond)
TIP39 Q130 1.25x25 TM1 polar (charge-assisted hydrogen bond)
TIP39 F141 1.36x36 TM1 hydrophobic
TIP39 Y152 1.47x47 TM1 polar (charge-assisted hydrogen bond)
TIP39 F243 3.36x36 TM3 hydrophobic
TIP39 L247 3.40x40 TM3 hydrophobic
TIP39 R305 ECL2 polar (charge-charge)
TIP39 W307 45.51x51 ECL2 polar (hydrogen bond with backbone)
TIP39 E308 45.52x52 ECL2 polar (hydrogen bond with backbone)
TIP39 L309 ECL2 hydrophobic
TIP39 Y318 5.39x39 TM5 polar (charge-assisted hydrogen bond)
TIP39 Y318 5.39x39 TM5 polar (charge-assisted hydrogen bond)
TIP39 Y318 5.39x39 TM5 polar (hydrogen bond)
TIP39 Q319 5.40x40 TM5 polar (charge-assisted hydrogen bond)
TIP39 I322 5.43x43 TM5 hydrophobic
TIP39 W391 7.35x34 TM7 hydrophobic
TIP39 L399 7.43x42 TM7 hydrophobic

Ligands

TIP39

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Residue Diagrams

A L S G F S I S Y G V T Y M V Y L R E F 1 M H L F V S F M L R A T S I F V K D R V 2 V L I W Y Y N T A L F Y I F M V V A I K 3 Y L W G F I L G I W G F P A A F V A A W A 4 F L I F N L G I A A L I P A Q Y I W K I D 5 L V L V L V F G V H Y I V F V C L 6 I S V F F G Q F S N F F L E C H M R I 7
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ICL1 R R L H ICL1ECL1 G V K E L E S L I M Q D D P Q N S I E A T S V D K S Q ECL1ICL2 A F F S D T K ICL2ECL2 D A R C W E L S ECL2ICL3 N A V G H ICL3ECL3 P H S F T ECL3N-term M A G L G A S L H V W G W L M L G S C L L A R A Q L D S D G T I T I E E Q I V L V L K A K V Q C E L N I T A Q L Q E G E G N C F P E W D G L I C W P R G T V G K I S A V P C P P Y I Y D F N H K G V A F R H C N P N G T W D F M H S L N K T W A N Y S D C L R F N-termC-term V D W K R T P P C G S R R C G S V L T T V T H S T S S Q S Q V A A S T R M V L I S G K A A K I A S R Q P D S H I T L P G Y V W S N S E Q D C L P H S F H E E T K E D S G R Q G D D I L M E K P S R P M E S N P D T E G C Q G E T E D V L C-term L Q P D I S I G K Q E F F E R L Y V M Y T V G Y S I S F G S L A V A I L I I G Y F C T R N Y I H M H L F V S F M L R A T S I F V K D R V V H A H I Y I G C K I A V V M F I Y F L A T N Y Y W I L V E G L Y L H N L I F V Y L W G F I L I G W G F P A A F V A A W A V A R A T L A A G D I K W I Y Q A P I L A A I G L N F I L F L N T V R V L A T K I W E T D T R K Q Y R K L A K S T L V L V L V F G V H Y I V F V C L G L G W E I R M H C E L F F N S F Q G F F V S I I Y C Y C N G E V K K W N L V Q A E M W S R S
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Residue Table


GPCRdb(A)
GPCRdb(B)
PTH2 receptor
TM1
1x21 1.25x25 Q130
1x32 1.36x36 F141
1x43 1.47x47 Y152
TM3
3x32 3.36x36 F243
3x36 3.40x40 L247
ECL2
45x51 45.51x51 W307
45x52 45.52x52 E308
TM5
5x43 5.39x39 Y318
5x44 5.40x40 Q319
5x47 5.43x43 I322
TM7
7x30 7.35x34 W391
7x38 7.43x42 L399